Zoledronic acid and irradiation in oral squamous cell carcinoma

Abstract

Zoledronic acid increases cytotoxic activity in the PE/CA-PJ15 cell line and reduces cell migration capacity. These findings suggest that combination therapy using biphosphates and radiation may offer a promising therapy.

Growth differentiation factor 15 as a radiation‐induced marker in oral carcinoma increasing radiation resistance

“…In head and neck cancer, a combination of growth factors such as survivin, Bax, Bcl‐2, Bcl‐X(L), COX‐2, and the p53 Arg72Pro polymorphism were described to strongly correlate with radioresponse . Moreover, drugs such as zoledronic acid increased cytotoxic activity in OSCC cell lines and reduced cell migration capacity . Concerning the role of GDF15 in radiation response of tumor cells, limited information is available so far.…”

Bevacizumab and sunitinib mediate osteogenic and pro-inflammatory molecular changes in primary human alveolar osteoblasts in vitro

“…The hypothesized pathogenic mechanisms that have reached broad acceptance are based on inflammation and/or infection, antiangiogenic properties, decreased bone turnover, altered immunity and soft tissue toxicity of bone-modifying agents [ 18 ]. Previous studies have addressed the effects of BPs in oral squamous cell carcinoma cultures [ 19 ] or murine osteoblast precursor cells [ 20 ]. However, the effects of antiangiogenic agents on osteoblasts and osteoclasts derived from the jaw bone as the main cells involved in bone homeostasis are elusive.…”

DoRes within CellMissy: dose-response analysis on cell migration and related data

“…When used in high-throughput fashion, these in vitro assays play a crucial role in the identification of biological agents and comparison of their potency (Nierode et al , 2016). An important type of study is a dose-response experiment, in which a specific compound is applied in parallel in different concentrations, and the relationship between the concentration of this compound to the response of the biological system under study is quantified, usually to determine the optimal dose of the compound (Lopez Jornet et al , 2015). The datasets obtained through such high-throughput dose-response experiments are often large and contain information on different levels, which necessitates data storage and automated analysis tools (Masuzzo et al , 2016).…”