Zoledronic acid-associated symmetrical drug-related intertriginous and flexural exanthema (SDRIFE): report of baboon syndrome in a woman with recurrent metastatic breast cancer after receiving zoledronic acid

Abstract

Zoledronic acid-associated symmetrical drug-related intertriginous and flexural exanthema (SDRIFE): report of baboon syndrome in a woman with recurrent metastatic breast cancer after receiving zoledronic acid Permalink

Delayed Inflammatory Reaction to Hyaluronic Acid Dermal Filler Following Zoledronic Acid Administration: A Case Report

“… 7 , 8 Baboon syndrome, a rare maculopapular rash secondary to a rare type IV hypersensitivity reaction associated with zoledronic acid, was reported in one patient. 9 …”

“…7,8 Baboon syndrome, a rare maculopapular rash secondary to a rare type IV hypersensitivity reaction associated with zoledronic acid, was reported in one patient. 9 In 2021, according to the International Society for Aesthetic Surgery (ISAPS), hyaluronic acid dermal filler was ranked as the second most common noninvasive aesthetic procedure performed internationally, with a 30.3% notable increase. 10 Delayed inflammatory reactions have been reported following hyaluronic acid dermal injection but are uncommon.…”

Lenalidomide-induced symmetrical drug-related intertriginous and flexural exanthema

“…Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is an immune-mediated type IV hypersensitivity reaction that occurs after systemic administration of the culprit medication. In 1984, SDRIFE was initially described as "baboon syndrome" because the rash resembled the red rump of baboons due to its distribution on the buttocks and inner thighs [1]. In 2004, Hausermann coined the term SDRIFE as a more appropriate name for the cutaneous reaction [2].…”

Zoledronate induced urticarial vasculitis

“…Common systemic side-effects caused by bisphosphonates include nausea, renal toxicity, osteonecrosis of jaw, nonspecific conjunctivitis, and atrial fibrillation. 1 Cutaneous adverse effects due to bisphosphonates are quite rare and include urticaria, 2 lichen planus (alendronate), 3 symmetrical drugrelated intertriginous and flexural exanthema (zoledronate), 4 fever with rash (zoledronate), 5 spongiotic dermatitis (alendronate), 6 interface dermatitis (zoledronate), 7 figurate erythema (alendronate), 8 and vasculitis (risedronate). 9 Vasculitis is inflammation of the vessel wall.…”