Zollinger-Ellison syndrome

Friesen, Stanley R.

doi:10.1016/s0011-3840(72)80001-7

Cited by 8 publications

(5 citation statements)

References 106 publications

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“…Increased gastric acid output has been observed in acromegaly, and immunofluorescence and ultrastructural studies revealing the underlying antral G cell hyperplasia have been made by Pearse and Bussolati (1970) and by Creutzfeldt et al (1971). A pituitary influence on islet cells, and on endocrine polypeptide neoplasms, has been postulated by Friesen et al (1970) and by Friesen (1972) following the observation that after hypophysectomy in Z-E syndrome with tumour a decrease in the size of metastases was observed, together with a fall in serum gastrin levels.…”

Section: Discussionmentioning

confidence: 99%

“…Our overall view, which closely follows concepts developed by Friesen (1968Friesen ( , 1972 is as follows:…”

Section: Case Number and Descriptionmentioning

confidence: 94%

“…Gastrin Assay (pg/ml plasma) Duration of Symptoms It is difficult to determine the exact incidence of pituitary abnormalities in the Z-E syndrome but pituitary tumours have been reported in at least 10% of Z-E patients (Ellison and Wilson, 1967) and in four out of 12 cases (33 %) by Friesen (1972). It is similarly difficult to ascertain the precise nature of pituitary abnormalities described in association with the Z-E syndrome.…”

Section: Case Number and Descriptionmentioning

confidence: 99%

“…3 Antral inhibition Friesen, 1972) produces a negative feedback 'gastric factor' which may come from antrum, fundus, or duodenum and which stimulates the pituitary to further production of the gastrinotrophic principle.…”

Section: Case Number and Descriptionmentioning

confidence: 99%

“…4 Acid hypersecretion by the parietal cells. 5 Antral inhibition factor (Friesen, 1972) producing a negative feedback effect stimulating the further production of (2), the gastrinotrophic factor. 6 Possible action ofantral inhibition factor on the islet cells of the pancreas.…”

Section: Case Number and Descriptionmentioning

confidence: 99%

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Two types of Zollinger-Ellison syndrome: immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states

Polak¹,

Stagg²,

Pearse³

1972

Gut

193

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SUMMARY In this survey the antral, pancreatic and, where present, the neoplastic gastrin cells, were studied in eight cases of the Zollinger-Ellison syndrome. The antral G cells alone were studied in one case of Z-E syndrome, seven cases of simple duodenal ulcer, and five cases of pernicious anaemia.The Z-E cases were divided into two numerically equal groups. The first group had 'short' histories, high serum gastrin levels, and profound antral G cell hyperplasia. The second group had 'long' histories, relatively lower serum gastrin levels, normal antral G cells, and either pancreatic D cell hyperplasia or gastrinoma.Antral G cell hyperplasia, with maximal gastrin storage and normal serum gastrin levels, was found in the duodenal ulcer cases. Antral G cell hyperplasia with minimal storage and high serum gastrin levels was observed in the cases of pernicious anaemia.On the basis of our findings we propose that there exist at least two distinct types (or perhaps stages) of the Z-E syndrome. Suggestions for their pathogenesis are offered.The combination of gastric hypersecretion, intractable peptic ulceration, and non-insulin-producing pancreatic islet cell tumours was noted by Sailer and Zinniger (1946), Forty and Barrett (1952), and by Strom (1953

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