Zollinger–Ellison syndrome in a 12-year-old child

Nath, Abir Lal; Saxena, Nandita; Kulkarni, Bharati; Borwankar, S. S.; Lahoti, Hemant N; Oak, Sanjay

doi:10.4103/0971-9261.207623

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…Because of its rarity, many cases of pediatric gastrinomas remain undiagnosed for years; evidence of digestive ulcers associated with elevated levels of fasting gastrin is usually diagnostic for a gastrinoma associated with Zollinger-Ellison syndrome, but these findings have to be correlated with advanced imaging investigations in order to assess tumor localization and invasion. In the pediatric population, the malignancy rate is close to 30%, poor prognosis being associated with tumor size (> 3 cm), metastatic disease (especially hepatic, lymph nodes and bone metastasis), female gender, inadequate gastric hypersecretion control as well as the histopathological features[ 15 ].…”

Section: Pancreatic Malignant Tumors In Childrenmentioning

confidence: 99%

Could the burden of pancreatic cancer originate in childhood?

Diaconescu¹,

Gîlcă-Blanariu²,

Poamaneagra³

et al. 2021

WJG

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The presence of pancreatic cancer during childhood is extremely rare, and physicians may be tempted to overlook this diagnosis based on age criteria. However, there are primary malignant pancreatic tumors encountered in pediatric patients, such as pancreatoblastoma, and tumors considered benign in general but may present a malignant potential, such as the solid pseudo-papillary tumor, insulinoma, gastrinoma, and vasoactive intestinal peptide secreting tumor. Their early diagnosis and management are of paramount importance since the survival rates tend to differ for various types of these conditions. Many pediatric cancers may present pancreatic metastases, such as renal cell carcinoma, which may evolve with pancreatic metastatic disease even after two or more decades. Several childhood diseases may create a predisposition for the development of pancreatic cancer during adulthood; hence, there is a need for extensive screening strategies and complex programs to facilitate the transition from pediatric to adult healthcare. Nevertheless, genetic studies highlight the fact the specific gene mutations and family aggregations may be correlated with a special predisposition towards pancreatic cancer. This review aims to report the main pancreatic cancers diagnosed during childhood, the most important childhood diseases predisposing to the development of pancreatic malignancies, and the gene mutations associates with pancreatic malignant tumors.

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Section: Pancreatic Malignant Tumors In Childrenmentioning

confidence: 99%

Could the burden of pancreatic cancer originate in childhood?

Diaconescu¹,

Gîlcă-Blanariu²,

Poamaneagra³

et al. 2021

WJG

View full text Add to dashboard Cite

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Islet Cell Adenoma

2018

Diagnostic Pathology: Pediatric Neoplasms

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Age-specific causes of upper gastrointestinal bleeding in children

Kocic,

Rasic,

Marusic

et al. 2023

World J Gastroenterol

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The etiology of upper gastrointestinal bleeding (UGIB) varies by age, from newborns to adolescents, with some of the causes overlapping between age groups. While particular causes such as vitamin K deficiency and cow’s milk protein allergy are limited to specific age groups, occurring only in neonates and infants, others such as erosive esophagitis and gastritis may be identified at all ages. Furthermore, the incidence of UGIB is variable throughout the world and in different hospital settings. In North America and Europe, most UGIBs are non-variceal, associated with erosive esophagitis, gastritis, and gastric and duodenal ulcers. In recent years, the most common causes in some Middle Eastern and Far Eastern countries are becoming similar to those in Western countries. However, variceal bleeding still predominates in certain parts of the world, especially in South Asia. The most severe hemorrhage arises from variceal bleeding, peptic ulceration, and disseminated intravascular coagulation. Hematemesis is a credible indicator of a UGI source of bleeding in the majority of patients. Being familiar with the most likely UGIB causes in specific ages and geographic areas is especially important for adequate orientation in clinical settings, the use of proper diagnostic tests, and rapid initiation of the therapy. The fundamental approach to the management of UGIB includes an immediate assessment of severity, detecting possible causes, and providing hemodynamic stability, followed by early endoscopy. Unusual UGIB causes must always be considered when establishing a diagnosis in the pediatric population because some of them are unique to children. Endoscopic techniques are of significant diagnostic value, and combined with medicaments, may be used for the management of acute bleeding. Finally, surgical treatment is reserved for the most severe bleeding.

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Zollinger–Ellison syndrome in a 12-year-old child

Abstract: The syndrome described by Zollinger and Ellison in 1955 is a rare clinical entity which is even rarer in children. This report describes a 12-year-old boy who presented with refractory peptic ulcer disease which was finally diagnosed to be due to a gastrinoma and was successfully treated.

Cited by 3 publications

References 8 publications

Could the burden of pancreatic cancer originate in childhood?

Could the burden of pancreatic cancer originate in childhood?

Islet Cell Adenoma

Age-specific causes of upper gastrointestinal bleeding in children

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