Zolpidem-induced macropsia in anorexic woman

Zolpidem reduces the blood oxygen level-dependent signal during visual system stimulation

“…Although this hypothesis is speculative, zolpidem was associated with an increase in blurred vision compared to a comparable short-acting benzodiazepine hypnotic (Mintzer et al, 1998), while a number of case reports have described zolpidem-induced hallucinatory experiences (Ansseau et al, 1992; de Haas et al, 2007; Huang et al, 2003; Iruela et al, 1993). Anecdotally, several participants reported such experiences during experimental sessions (particularly after the highest dose of zolpidem but not to the extent of qualifying as an adverse event), but the mechanism by which zolpidem mediates this type of sensory effect in healthy individuals is unknown.…”

Zolpidem-induced suicide attempt: a case report

“…In 1992, Ansseau et al [11] reported the cases of 2 patients who developed visual hallucinations and amnesia shortly after the intake of zolpidem. Iruela et al [12] reported a case of a patient presenting with macropsia without amnesia. therefore, the number of reports of neuropsychiatric reactions associated with zolpidem use has increased, indicating that zolpidem should not be considered risk free, even at therapeutic doses, and might produce transient cognitive and behavioral impairments similar to those caused by benzodiazepines [8,13-15].…”

Tolerância ao fenômeno alucinatório induzido pelo zolpidem: relato de caso

“…higher than in men, 4,9,12,16 or by the competition for the protein bond in concomitant use with drugs that have high affinity with proteins, such as some antidepressants. 1,11,16 The phenomenon, however, has been described in male patients 13,15,19 taking low doses and in monotherapy [8][9][10]13 as well as it was described in normal volunteers.…”

“…1,11,16 The phenomenon, however, has been described in male patients 13,15,19 taking low doses and in monotherapy [8][9][10]13 as well as it was described in normal volunteers. 21 The rapid absorption of zolpidem may decrease the surveillance level, facilitating the occurrence of hypnagogic distortions.…”

“…In Switzerland, there were five Up to the present, there are 24 cases of zolpidem-induced hallucinations, 1,4,[8][9][10][11][12][13][14][15][16][17][18][19][20] of these, 20…”