Zolpidem-induced sleep-related eating disorder

Yun, Chang-Ho; Ji, Ki‐Hwan

doi:10.1016/j.jns.2009.09.026

Cited by 37 publications

(22 citation statements)

References 14 publications

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“…16 Others have commented that RLS appears to be ubiquitous in the setting of zolpidem-induced SRED. 21 In fact, we are unaware of any zolpidem-induced SRED report where RLS was explicitly considered and subsequently not discovered. [16][17][18][19][20][21] Tellingly, NE (both conscious and amnestic) among our INS patients was rare ( Table 3).…”

Section: Amnestic Sred Is Predominantly Mistreatment Of Rls As Insmentioning

confidence: 99%

“…[13][14][15] This finding has been particularly profound among patients with medication-induced SRED. [16][17][18][19][20][21] In fact, even among SRED cases where RLS frequency was not addressed, there is a peculiar incidence of conditions frequently comorbid with RLS, such as Parkinson disease 22 and narcolepsy. 23 Like nondysfunctional nocturnal eating (a non-pathological variation of SRED), RLS may be mild or only minimally interfering with sleep onset.…”

Section: Epidemiology Of Ne/sred and Rlsmentioning

confidence: 99%

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Restless Nocturnal Eating: A Common Feature of Willis-Ekbom Syndrome (RLS)

Howell

Schenck

2012

Journal of Clinical Sleep Medicine

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upon SRED. However, we have noticed subtler non-dysfunctional forms of NE, commonly in the setting of RLS. Also, we have noted that many cases of zolpidem-induced SRED had been originally misdiagnosed as having psychophysiological insomnia (INS), a condition for which a benzodiazepine receptor agonist was prescribed, but later noted to have underlying motor restlessness as the cause of their sleep diffi culties.To establish whether NE is common in RLS and whether NE is a product of frequent nocturnal awakenings, we compared the frequency of NE as well as SRED among patients presenting with RLS and INS, a distinct condition of cognitive hypervigilance that manifests with frequent nocturnal awaken- Measurements and Results:Patients presenting with RLS (n = 88) or INS (n = 42) were queried for the presence of NE and SRED. RLS patients described nocturnal eating (61%) and SRED (36%) more frequently than INS patients (12% and 0%; both p < 0.0001). These fi ndings were not due to arousal frequency, as INS patients were more likely to have prolonged nightly awakenings (93%) than RLS patients (64%; p = 0.003). Among patients on sedative-hypnotics, amnestic SRED and sleepwalking were more common in the setting of RLS (80%) than INS (8%; p < 0.0001). Further, NE and SRED in RLS were not secondary to dopaminergic therapy, as RLS patients demonstrated a substantial drop (68% to 34%; p = 0.0026) in the frequency of NE after dopamine agents were initiated, and there were no cases of dopaminergic agents inducing novel NE or SRED. Conclusion: NE is common in RLS and not due to frequent nocturnal awakenings or dopaminergic agents. Amnestic SRED occurs predominantly in the setting of RLS mistreatment with sedating agents. In light of previous reports, these fi ndings suggest that nocturnal eating is a non-motor manifestation of RLS with several clinical implications discussed here. S C I E N T I F I C I N V E S T I g A T I O N SR estless legs syndrome, or Willis-Ekbom Syndrome (labeled RLS), is characterized by an underlying discomfort, primarily in the lower extremities that compels the affl icted to move. These symptoms are relieved, although only momentarily, with movement and may interfere with sleep initiation or maintenance. 1 RLS has been associated with non-motor phenomena. In particular, patients with RLS often describe other comorbidities such as mood and anxiety disorders, 2 as well as other nocturnal compulsions such as nocturnal smoking that interfere with sleep.3 Further, patients with these non-motor manifestations of RLS have more severe motor restlessness as measured by the International RLS Rating Scale. Recently, an investigation demonstrated a high frequency of dysfunctional nocturnal eating (SRED) in patients with RLS. This community-based case-control study found that 33 of 100 RLS patients met criteria for SRED compared to only 1% of normal population controls. 4 The authors pondered whether SRED was related to underlying RLS brain pathology or whether it was merely "killing time" during prolonged nocturn...

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Section: Amnestic Sred Is Predominantly Mistreatment Of Rls As Insmentioning

confidence: 99%

Section: Epidemiology Of Ne/sred and Rlsmentioning

confidence: 99%

Restless Nocturnal Eating: A Common Feature of Willis-Ekbom Syndrome (RLS)

Howell

Schenck

2012

Journal of Clinical Sleep Medicine

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“…Zolpidem is gaining popularity as a short-acting hypnotic with few side effects, nevertheless, some side effects such as sedation, somnolence, dizziness, diarrhea, headache, fatigue, memory loss, visual hallucination, and rare cases of sleep walking, dependency, sleep-related eating disorder, and suicide attempting are reported along with this medication (2,4,(16)(17)(18)(19). Perceptional symptoms such as visual hallucination is also reported after taking Zolpidem (4).…”

Section: Discussionmentioning

confidence: 99%

Zolpidem Induces Depersonalization and Derealization Symptoms: A Case Report

Abedini

Esmaeili

2017

Mod Care J

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The purpose of this study is to present the case of Depersonalization and Derealization induced by Zolpidem. symptoms of depersonalization may occur in individuals who suffer from additional mental disorders, various medical conditions, and/or have taken certain medications. The subject was a 24-year-old male patient who has consumed 20 mg of Zolpidem for the treatment of primary insomnia. He complained that he suffered from a strange feeling in his limbs and hands along with a feeling of change in the environment immediately after the medication. His symptoms ceased after treatment was stopped and recurred when he restarted the drug. Medications and medical as well as psychiatric conditions, which are associated with causing symptoms of depersonalization, are reported here and the postulated pathogenesis by which some of these drugs induced depersonalization symptoms is also discussed. Medication-associated with depersonalization symptoms are typically resolved once the inducing drug has been withdrawn. We performed research questions regarding the side effect of Zolpidem and etiology of derealization as well as depersonalization in all of the databases and citation indexes. There were no results relevant to the research question. Therefore, we should assess medications such as Zolpidem as well as psychiatric conditions that are associated with causing symptoms of depersonalization.

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“…Patogenezde kullanılan antipsikotik ilaçlar, stres, anksiyete, alkolizm, sigara ve alkolün ani bırakılması, lityum, trisiklik antidepresan ilaçlar ve özellikle de zolpidem suçlanmıştır. 3,4 Bizim olgumuzda antihipertansif ilaç kullanımı dışında başka bir ilaç kullanım öyküsü yoktu. Yapılan görüntüleme incelemesi normal sınırlarda idi.…”

Section: Discussionunclassified