Zolpidem use and risk of suicide: A systematic review and meta-analysis

Khan, Hiba; Garg, Aakriti; Yasmeen,; Agarwal, Nidhi; Yadav, Deepak; Khan, Mohd Ashif; Hussain, Salman

doi:10.1016/j.psychres.2022.114777

Cited by 13 publications

(3 citation statements)

References 41 publications

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“…The Newcastle-Ottawa Scale was applied to evaluate the methodological rigor of the literature, taking into account three factors: Selection of the study population (4 points), comparability between groups (2 points), and outcome parameters (3 points). A maximum of nine points could be obtained, with studies having a score of six or more deemed as being of high quality[ 9 ].…”

Section: Methodsmentioning

confidence: 99%

Sarcopenia adversely impacts clinical outcomes in patients undergoing pancreaticoduodenectomy: A systematic review and meta-analysis

Zhang,

Ma,

et al. 2024

World J Gastrointest Surg

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BACKGROUND Sarcopenia is a syndrome marked by a gradual and widespread reduction in skeletal muscle mass and strength, as well as a decline in functional ability, which is associated with malnutrition, hormonal changes, chronic inflammation, disturbance of intestinal flora, and exercise quality. Pancreatoduodenectomy is a commonly employed clinical intervention for conditions such as pancreatic head cancer, ampulla of Vater cancer, and cholangiocarcinoma, among others, with a notably high rate of postoperative complications. Sarcopenia is frequent in patients undergoing pancreatoduodenectomy. However, data regarding the effects of sarcopenia in patients undergoing pancreaticoduodenectomy (PD) are both limited and inconsistent. AIM To assess the influence of sarcopenia on outcomes in patients undergoing PD. METHODS The PubMed, Cochrane Library, Web of Science, and Embase databases were screened for studies published from the time of database inception to June 2023 that described the effects of sarcopenia on the outcomes and complications of PD. Two researchers independently assessed the quality of the data extracted from the studies that met the inclusion criteria. Meta-analysis using RevMan 5.3.5 and Stata 14.0 software was conducted. Forest and funnel plots were used, respectively, to demonstrate the outcomes of the sarcopenia group vs the non-sarcopenia group after PD and to evaluate potential publication bias. RESULTS Sixteen studies encompassing 2381 patients were included in the meta-analysis. The patients in the sarcopenia group (n = 833) had higher overall postoperative complication rates [odds ratio (OR) = 3.42, 95% confidence interval (CI): 1.95-5.99, P < 0.0001], higher Clavien-Dindo class ≥ III major complication rates (OR = 1.41, 95%CI: 1.04-1.90, P = 0.03), higher bacteremia rates (OR = 4.46, 95%CI: 1.42-13.98, P = 0.01), higher pneumonia rates (OR = 2.10, 95%CI: 1.34-3.27, P = 0.001), higher pancreatic fistula rates (OR = 1.42, 95%CI: 1.12-1.79, P = 0.003), longer hospital stays (OR = 2.86, 95%CI: 0.44-5.28, P = 0.02), higher mortality rates (OR = 3.17, 95%CI: 1.55-6.50, P = 0.002), and worse overall survival (hazard ratio = 2.81, 95%CI: 1.45-5.45, P = 0.002) than those in the non-sarcopenia group (n = 1548). However, no significant inter-group differences were observed regarding wound infections, urinary tract infections, biliary fistulas, or postoperative digestive bleeding. CONCLUSION Sarcopenia is a common comorbidity in patients undergoing PD. Patients with preoperative sarcopenia have increased rates of complications and mortality, in addition to a poorer overall survival rate and longer hospital stays after PD.

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Section: Methodsmentioning

confidence: 99%

Sarcopenia adversely impacts clinical outcomes in patients undergoing pancreaticoduodenectomy: A systematic review and meta-analysis

Zhang,

Ma,

et al. 2024

World J Gastrointest Surg

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“…Moreover, zolpidem strengthens hippocampal-prefrontal network coupling (Kersanté et al, 2023) and is correlated with improved memory task performance on the following day (Niknazar et al, 2015;Zhang et al, 2020;Leong et al, 2022). Unfortunately, zolpidem also enhances negative emotional memory consolidation and a metastudy finds zolpidem use is associated with increased suicide rates (Simon et al, 2021;Khan et al, 2022). Thus, zolpidem may only be an effective approach for enhancing slow waves, spindles, and memory in certain subpopulations.…”

mentioning

confidence: 99%

Memory retention following acoustic stimulation in slow-wave sleep: a meta-analytic review of replicability and measurement quality

Harlow,

Jané,

Read

et al. 2023

Front. Sleep

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The role of slow oscillations and spindles during sleep on memory retention has become an area of great interest in the recent decade. Accordingly, there are multiple studies that examine the efficacy of acoustic stimulation during sleep to facilitate slow oscillations and associated memory retention. Here, we run meta-analyses on a current set of 14 studies that use audible noise-burst sound stimulation to modulate overnight retention of word pairs (kS = 12 studies, kES = 14 effect sizes, n = 206 subjects). Our meta-analyses demonstrate a steady, yearly decline in effect size that accounts for 91.8% of the heterogeneity between studies. We find that the predicted effect on memory retention in 2013 favored the acoustic stimulation condition at dδ = 0.99 (95% CI [0.49, 1.49]), while the predicted effect in 2021 declined to a moderate and significant effect favoring no acoustic stimulation at dδ = −0.39 (95% CI [−0.73, −0.05]). Our meta-regression model finds no coded study-level characteristics could account for the decline in effect sizes over time other than the publication date alone. Using available data, we estimate that 34% of subjects are not actually blind to the acoustic stimulation condition due to hearing acoustic stimulation during sleep. In addition, we find that the test-retest reliability of memory retention scores is nearly zero (ρd = 0.01, 95% CI [−0.18, 0.21]), and through simulation demonstrate the impact this has on statistical power and observed effect sizes. Based on our analyses, we discuss the need for larger sample sizes, true placebo controls, age range restrictions, open-data sharing, and improvements in the reliability of memory retention tasks.

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“…Pesquisas comprovam um aumento de até 113% na procura de medicamentos destinados ao tratamento de insônia, ansiedade e depressão, comparado aos seis meses anteriores à pandemia. O zolpidem, um dos fármacos hipnóticos não benzodiazepínicos mais comumente prescritos para insônia e depressão, teve seu consumo aumentado durante a pandemia da COVID-19 (MEDICINA S/A, 2021; KHAN et al, 2022).…”

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Zolpidem: Aumento Do Seu Uso Associado Ao Cenário Pandêmico Da Covid-19

Santos

Souza

Machado

et al. 2023

Braz. J. Implantol. Health Sci.

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No início de 2020 a Organização Mundial de Saúde (OMS) definiu a Covid-19 como uma doença pandêmica e, desde então foram criados diversos protocolos preventivos de propagação do vírus incluindo o isolamento social, algo que, somado a todas as incertezas que cercavam o novo cenário mundial resultou em um aumento do sofrimento psicológico e consequentemente o uso de substâncias psicoativas. No Brasil, a comercialização dos psicofármacos aumentou 17% em 2020 e 13% só nos primeiros cinco meses de 2021, em específico o zolpidem, que teve o maior crescimento (113%) no período de 2019 a 2021. O presente estudo se propôs a analisar o aumento do uso do zolpidem durante a pandemia da Covid 19 através de uma revisão narrativa baseada em artigos científicos e compêndios oficiais. Desse modo, foi constatado que a crescente procura do zolpidem ainda traz uma problemática maior, o uso indiscriminado do medicamento e diversos problemas associados, fazendo-se necessária a implementação de estratégias para assegurar o uso racional da substância, como a terapia cognitiva comportamental (TCCs), cursos de educação em saúde e a necessidade de reavaliar a notificação do receituário, visto que, atualmente, o zolpidem é adquirido por meio de receitas do tipo B1 e de controle especial, podendo implicar em um tempo de tratamento maior que o indicado.

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Zolpidem use and risk of suicide: A systematic review and meta-analysis

Cited by 13 publications

References 41 publications

Sarcopenia adversely impacts clinical outcomes in patients undergoing pancreaticoduodenectomy: A systematic review and meta-analysis

Sarcopenia adversely impacts clinical outcomes in patients undergoing pancreaticoduodenectomy: A systematic review and meta-analysis

Memory retention following acoustic stimulation in slow-wave sleep: a meta-analytic review of replicability and measurement quality

Zolpidem: Aumento Do Seu Uso Associado Ao Cenário Pandêmico Da Covid-19

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