Zona incerta lesions impair osmotic but not hypovolemic thirst

Walsh, Linda L.; Grossman, Sebastian P.

doi:10.1016/0031-9384(76)90307-3

Cited by 42 publications

(3 citation statements)

References 19 publications

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“…which binds circulating All [98], also contains an All-immunoreactive terminal field which appears to arise from cells in the lateral hypothalamus, zona incerta, and nucleus reuniens. It is noteworthy that both the zona in certa [19,99] and the lateral hypothalamic area [33,62,95] seem to play a role in the behavioral control of fluid bal ance, particularly to osmotic stimuli. Perhaps this is achieved in part through an All-containing projection to the SFO.…”

Section: Discussionmentioning

confidence: 99%

Organization of Angiotensin II Immunoreactive Cells and Fibers in the Rat Central Nervous System

1985

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The distribution of angiotensin II (AII)-immunoreactive cells and fibers was examined in adult male Sprague-Dawley rats with and without colchicine pretreatment. As seems to be the case for a number of other neuropeptides, AII is preferentially found in brain stem, hypothalamic, and limbic structures involved in the control of homeostatic functions. AII-stained cell bodies were most prominent in magnocellular parts of the paraventricular and supraoptic nuclei, and cells were also found in parvocellular parts of the former. Other hypothalamic nuclei containing cell bodies include the suprachiasmatic nucleus, the medial preoptic area, and perifornical parts of the lateral hypothalamic area. Of considerable interest was robust staining in several of the circumventricular organs, in particular the subfornical organ, where both cells and fibers were found. The results of water deprivation and nephrectomy suggest that this staining does not represent uptake of circulating peptide, but instead, represents AII-containing neural connections. In the thalamus, AII-stained cells were found in the paraventricular nucleus, the central medial nucleus, the nucleus reuniens, and rostral parts of the zona incerta. Two cell groups in the basal telencephalon, in the dorsal part of the bed nucleus of the stria teminalis and in the medial nucleus of the amygdala, lay at either end of an AII-stained pathway coursing through the stria terminalis. In the midbrain, immunoreactive cells were found in the interpeduncular and peripeduncular nuclei, and one pontine cell group was detected in the most lateral part of the lateral parabrachial nucleus. The only AII-stained cells in the medulla were in the nucleus of the solitary tract, near the margin of the area postrema. Fibers were found at all levels of the central nervous system, from the olfactory bulbs to the spinal cord, where terminal fields were observed in the substantia gelatinosa and in the intermediolateral cell column. Longitudinally oriented fibers were present throughout the periventricular fiber system and in the medial forebrain bundle, including its caudal extension in ventrolateral parts of the brain stem. It is suggested that, at many different levels, AIIserves as both a hormone and neurotransmitter for fluid balance.

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Section: Discussionmentioning

confidence: 99%

Organization of Angiotensin II Immunoreactive Cells and Fibers in the Rat Central Nervous System

1985

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“…However, there is little to no experimental evidence supporting these interesting clinical observations. Located between the thalamus and the hypothalamus, the ZI is an elongated string-like structure that has been implicated in a wide range of functions, varying from neuronal development (13), hormonal regulation (14,15), ingestion (16)(17)(18), sleep (19,20), sensory processing (21,22), and pain (23). More recently, a stream of research showcased the implication of the ZI in emotionally related experiences and adaptive defensive behaviors.…”

Section: Introductionmentioning

confidence: 99%

Zona incerta subpopulations differentially encode and modulate anxiety

Rizzi

Tan

2021

Sci. Adv.

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Despite recent clinical observations linking the zona incerta (ZI) to anxiety, little is known about whether and how the ZI processes anxiety. Here, we subject mice to anxious experiences and observe an increase in ZI c-fos-labeled neurons and single-cell calcium activity as well as an efficient effect of ZI infusion of diazepam, a classical anxiolytic drug. We further identify that somatostatin (SOM)-, calretinin (CR)-, and vesicular glutamate transporter-2 (Vglut2)expressing cells display unique electrophysiological profiles; however, they similarly respond to anxiety-provoking stimuli and to diazepam. Optogenetic manipulations reveal that each of these ZI neuronal populations triggers specific anxiety-related behavioral phenotypes. Activation of SOM-expressing neurons induced anxiety, while photoactivation of CR-positive cells and photoinhibition of Vglut2-expressing neurons produce anxiolysis. Furthermore, activation of CR-and Vglut2-positive cells provokes rearing and jumps, respectively. Our findings provide the first experimental evidence that ZI subpopulations encode and modulate different components of anxiety.

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“…Located between the thalamus and the hypothalamus, the ZI is an elongated stringlike structure that has been implicated in a wide range of functions, varying from neuronal development (13), hormonal regulation (14,15), ingestion (16)(17)(18), sleep (19,20), sensory processing (21,22) and pain (23,23). More recently, a stream of research showcased the implication of the ZI in emotionally related experiences and adaptive defensive behaviors.…”

Section: Introductionmentioning

confidence: 99%

Zona Incerta subpopulations differentially encode and modulate anxiety

Rizzi

Tan

2020

Preprint

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Despite recent clinical observations linking the Zona Incerta (ZI) to anxiety, little is known about whether and how the ZI processes anxiety. Here, we subject mice to anxious experiences and observe an increase in ZI cfos-labelled neurons and single-cell calcium activity as well as an efficient effect of ZI infusion of diazepam a classical anxiolytic drug. We further identify that somatostatin-(SOM), calretinin-(CR), and vesicular glutamate transporter-2 (Vglut2)-expressing cells display unique electrophysiological profiles; yet they similarly respond to anxiety-provoking stimuli and to diazepam. Interestingly, optogenetic manipulations reveals that each of these ZI neuronal population triggers specific anxiety-related behavioral phenotypes. Activation of SOM-expressing neurons induced anxiety while in stark contrast, photo-activation of CR-positive cells and photo-inhibition of Vglut2-expressing neurons produce anxiolysis. Furthermore, activation of CR- and Vglut2-positive cells provokes rearing and jumps; respectively. Our findings provide the first experimental evidence that ZI subpopulations encode and modulate different components of anxiety.

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Zona incerta lesions impair osmotic but not hypovolemic thirst

Cited by 42 publications

References 19 publications

Organization of Angiotensin II Immunoreactive Cells and Fibers in the Rat Central Nervous System

Organization of Angiotensin II Immunoreactive Cells and Fibers in the Rat Central Nervous System

Zona incerta subpopulations differentially encode and modulate anxiety

Zona Incerta subpopulations differentially encode and modulate anxiety

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