Zona pellucida thickness variation and occurrence of visible mononucleated blastomeres in preembryos are associated with a high pregnancy rate in IVF treatment

Palmstierna, Måns; Murkes, Daniel; Csemiczky, G.; Andersson, Ola; Wramsby, Håkan

doi:10.1007/bf02766828

Cited by 68 publications

(33 citation statements)

References 23 publications

(28 reference statements)

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“…Possibly the dynamics of variation of the Z.p. is a more precise prediction of the therapy's success [28] and is superior to individual measurement.…”

Section: Discussionmentioning

confidence: 99%

Is the Zona pellucida Thickness of Metaphase-II Oocytes in an IVF/ICSI Program Influenced by the Patient’s Age?

Nawroth

Müller²,

Wolf

et al. 2001

Gynecol Obstet Invest

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Zona pellucida (Z.p.) thickness is believed to be considerably influenced by hormonal stimulation. Assessments of the influence of the patient’s age on Z.p. thickness have been at variance. In our study we wanted to investigate, among several other parameters, the age of the patient as a possible factor influencing Z.p. thickness. Prior to intracytoplasmatic sperm injection (ICSI) we determined the mean thickness of the Z.p. of 843 metaphase-II oocytes from 100 patients, which had been obtained after ovarian stimulation in an in vitro fertilization (IVF)/ICSI program. The mean thickness of the Z.p. was significantly positively correlated with the age of the patient (p = 0.000, r = 0.129). When the intraindividual mean values of Z.p. thickness (n = 100) were used, a positive correlation with age (p = 0.174, r = 0.137) remained. However, this correlation was no longer significant. It is concluded that, beside other factors, a thicker Z.p. could be responsible for the possibly lower fertilization rate of older patients in a conventional IVF program.

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“…Possibly the dynamics of variation of the Z.p. is a more precise prediction of the therapy's success [28] and is superior to individual measurement.…”

Section: Discussionmentioning

confidence: 99%

Is the Zona pellucida Thickness of Metaphase-II Oocytes in an IVF/ICSI Program Influenced by the Patient’s Age?

Nawroth

Müller²,

Wolf

et al. 2001

Gynecol Obstet Invest

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show abstract

“…The appearance of the ZP has been indicated as a predictor of development (45,46). It is suggested that embryos with a zona of uneven thickness are more likely to implant, possibly because of hatching being easier.…”

Section: Sjöblom Embryo Score and Blastocyst Development Fertil Stementioning

confidence: 98%

Prediction of embryo developmental potential and pregnancy based on early stage morphological characteristics

Sjöblom

Menezes

Cummins

et al. 2006

Fertility and Sterility

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“…Indeed, overall ZP thickness and its variation during preimplantation development (7)(8)(9) were found to be correlated to pregnancy outcome. However, it has been shown that the mean difference in thickness between zonae from conception cycles and failed ones was approximately 1mm (6), a value that is beyond the limit of provability of most systems designed for measuring cells.…”

mentioning

confidence: 96%

Automatic user-independent zona pellucida imaging at the oocyte stage allows for the prediction of preimplantation development

Ebner¹,

Balaban

Moser³

et al. 2010

Fertility and Sterility

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Zona pellucida thickness variation and occurrence of visible mononucleated blastomeres in preembryos are associated with a high pregnancy rate in IVF treatment

Cited by 68 publications

References 23 publications

Is the Zona pellucida Thickness of Metaphase-II Oocytes in an IVF/ICSI Program Influenced by the Patient’s Age?

Is the Zona pellucida Thickness of Metaphase-II Oocytes in an IVF/ICSI Program Influenced by the Patient’s Age?

Prediction of embryo developmental potential and pregnancy based on early stage morphological characteristics

Automatic user-independent zona pellucida imaging at the oocyte stage allows for the prediction of preimplantation development

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