Zonal Intratumoral Delivery of Nanoparticles Guided by Surface Functionalization

Terracciano, Rossana; Carcamo-Bahena, Yareli; Royal, Amber Lee R.; Messina, Luca; Delk, Jack; Butler, E. Brian; Demarchi, Danilo; Grattoni, Alessandro; Wang, Zhihui; Cristini, Vittorio; Dogra, Prashant; Filgueira, Carly S.

doi:10.1021/acs.langmuir.2c02319

Cited by 7 publications

(1 citation statement)

References 52 publications

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“…However, some points need to be considered: First, the method of inserting the nanocarrier into the cells and the efficiency rate of nanoparticle engulfment. Considering the clinical management, it is advantageous to use autologous cells and a favorable chemotactic gradient, ensuring concentration of the drug dose [75].…”

Section: Nanotechnology and Term (Tissue Engineering And Regenerative...mentioning

confidence: 99%

Magnetic Nanostructures and Stem Cells for Regenerative Medicine, Application in Liver Diseases

Silva

Dias

Cardoso

et al. 2023

IJMS

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The term “liver disease” refers to any hepatic condition that leads to tissue damage or altered hepatic function and can be induced by virus infections, autoimmunity, inherited genetic mutations, high consumption of alcohol or drugs, fat accumulation, and cancer. Some types of liver diseases are becoming more frequent worldwide. This can be related to increasing rates of obesity in developed countries, diet changes, higher alcohol intake, and even the coronavirus disease 2019 (COVID-19) pandemic was associated with increased liver disease-related deaths. Although the liver can regenerate, in cases of chronic damage or extensive fibrosis, the recovery of tissue mass is impossible, and a liver transplant is indicated. Because of reduced organ availability, it is necessary to search for alternative bioengineered solutions aiming for a cure or increased life expectancy while a transplant is not possible. Therefore, several groups were studying the possibility of stem cells transplantation as a therapeutic alternative since it is a promising strategy in regenerative medicine for treating various diseases. At the same time, nanotechnological advances can contribute to specifically targeting transplanted cells to injured sites using magnetic nanoparticles. In this review, we summarize multiple magnetic nanostructure-based strategies that are promising for treating liver diseases.

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Section: Nanotechnology and Term (Tissue Engineering And Regenerative...mentioning

confidence: 99%

Magnetic Nanostructures and Stem Cells for Regenerative Medicine, Application in Liver Diseases

Silva

Dias

Cardoso

et al. 2023

IJMS

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Polyester nanoparticles delivering chemotherapeutics: Learning from the past and looking to the future to enhance their clinical impact in tumor therapy

Longobardi,

Moore,

Conte

et al. 2024

WIREs Nanomed Nanobiotechnol

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Polymeric nanoparticles (NPs), specifically those comprised of biodegradable and biocompatible polyesters, have been heralded as a game‐changing drug delivery platform. In fact, poly(α‐hydroxy acids) such as polylactide (PLA), poly(lactide‐co‐glycolide) (PLGA), and poly(ε‐caprolactone) (PCL) have been heavily researched in the past three decades as the material basis of polymeric NPs for drug delivery applications. As materials, these polymers have found success in resorbable sutures, biodegradable implants, and even monolithic, biodegradable platforms for sustained release of therapeutics (e.g., proteins and small molecules) and diagnostics. Few fields have gained more attention in drug delivery through polymeric NPs than cancer therapy. However, the clinical translational of polymeric nanomedicines for treating solid tumors has not been congruent with the fervor or funding in this particular field of research. Here, we attempt to provide a comprehensive snapshot of polyester NPs in the context of chemotherapeutic delivery. This includes a preliminary exploration of the polymeric nanomedicine in the cancer research space. We examine the various processes for producing polyester NPs, including methods for surface‐functionalization, and related challenges. After a detailed overview of the multiple factors involved with the delivery of NPs to solid tumors, the crosstalk between particle design and interactions with biological systems is discussed. Finally, we report state‐of‐the‐art approaches toward effective delivery of NPs to tumors, aiming at identifying new research areas and re‐evaluating the reasons why some research avenues have underdelivered. We hope our effort will contribute to a better understanding of the gap to fill and delineate the future research work needed to bring polyester‐based NPs closer to clinical application.This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Thiol functionalised gold nanoparticles loaded with methotrexate for cancer treatment: From synthesis to in vitro studies on neuroblastoma cell lines

Salamone

Rutigliano

Pennacchi

et al. 2023

Journal of Colloid and Interface Science

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Zonal Intratumoral Delivery of Nanoparticles Guided by Surface Functionalization

Cited by 7 publications

References 52 publications

Magnetic Nanostructures and Stem Cells for Regenerative Medicine, Application in Liver Diseases

Magnetic Nanostructures and Stem Cells for Regenerative Medicine, Application in Liver Diseases

Polyester nanoparticles delivering chemotherapeutics: Learning from the past and looking to the future to enhance their clinical impact in tumor therapy

Thiol functionalised gold nanoparticles loaded with methotrexate for cancer treatment: From synthesis to in vitro studies on neuroblastoma cell lines

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