Zonisamide block of cloned human T-type voltage-gated calcium channels

Matar, Nora; Jin, Wanqin; Wrubel, H.; Hescheler, Jürgen; Schneider, Toni; Weiergräber, Marco

doi:10.1016/j.eplepsyres.2008.11.010

Cited by 49 publications

(32 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, as noted earlier, T-type calcium channels are important targets for treating absence seizures, with ethosuximide being one of the archetypal T-type channel blocking antiepileptic drugs. Other clinically used antiepileptic drugs with at least partial action on T-type calcium channels include zonisamide (Matar et al, 2009) and valproic acid (Todorovic and Lingle, 1998).…”

Section: Ca V 3 Channel Pathophysiologymentioning

confidence: 99%

The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential

Zamponi¹,

Striessnig²,

Koschak³

et al. 2015

Pharmacol Rev

907

992

View full text Add to dashboard Cite

Section: Ca V 3 Channel Pathophysiologymentioning

confidence: 99%

The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential

Zamponi¹,

Striessnig²,

Koschak³

et al. 2015

Pharmacol Rev

907

992

View full text Add to dashboard Cite

“…Cite this article as Cold Spring Harb Perspect Med 2016;6:a022723 dition, is effective in the treatment of generalized tonic -clonic seizures and cortical myoclonus, and also blocks T-type channels (Suzuki et al 1992;Biton 2007;Matar et al 2009). Levetiracetam, an antiepileptic with broad-spectrum activity, binds to the presynaptic vesicle protein SV2A (Lynch et al 2004) and may block HVA channels either directly or indirectly (Lukyanetz et al 2002;Lee et al 2009).…”

Section: Calcium Channels and Epilepsymentioning

confidence: 99%

The Role of Calcium Channels in Epilepsy

Rajakulendran

Hanna

2016

Cold Spring Harb Perspect Med

View full text Add to dashboard Cite

A central theme in the quest to unravel the genetic basis of epilepsy has been the effort to elucidate the roles played by inherited defects in ion channels. The ubiquitous expression of voltage-gated calcium channels (VGCCs) throughout the central nervous system (CNS), along with their involvement in fundamental processes, such as neuronal excitability and synaptic transmission, has made them attractive candidates. Recent insights provided by the identification of mutations in the P/Q-type calcium channel in humans and rodents with epilepsy and the finding of thalamic T-type calcium channel dysfunction in the absence of seizures have raised expectations of a causal role of calcium channels in the polygenic inheritance of idiopathic epilepsy. In this review, we consider how genetic variation in neuronal VGCCs may influence the development of epilepsy.

show abstract

“…Among the dihydropyridine class, one subclass blocks only L-type calcium channels and the other subclass blocks both L-type and T-type calcium channels. The latter subclass includes amlodipine, aranidipine, azelnidipine, barnidipine, benidipine, efonidipine, nicardipine, and nimodipine [2,21,69,67,6,19,20,45,52]. Of these listed, amlodipine, nicardipine, and nimodipine are FDA approved for use in the United States (Table 1).…”

Section: Overview Of T-type Calcium Channel Blockersmentioning

confidence: 99%

T-type calcium channel blockers as neuroprotective agents

Kopecky

Liang

Bao

2014

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

T-type calcium channels are expressed in many diverse tissues, including neuronal, cardiovascular, and endocrine. T-type calcium channels are known to play roles in the development, maintenance, and repair of these tissues but have also been implicated in disease when not properly regulated. Calcium channel blockers have been developed to treat various diseases and their use clinically is widespread due to both their efficacy as well as their safety. Aside from their established clinical applications, recent studies have suggested neuroprotective effects of T-type calcium channels blockers. Many of the current T-type calcium channel blockers could act on other molecular targets besides T-type calcium channels making it uncertain whether their neuroprotective effects are solely due to blocking of T-type calcium channels. In this review, we discuss these drugs as well as newly developed chemical compounds that are designed to be more selective for T-type calcium channels. We review in vitro and in vivo evidence of neuroprotective effects by these T-type calcium channel blockers. We conclude by discussing possible molecular mechanisms underlying neuroprotective effects by T-type calcium channel blockers.

show abstract

Zonisamide block of cloned human T-type voltage-gated calcium channels

Cited by 49 publications

References 60 publications

The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential

The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential

The Role of Calcium Channels in Epilepsy

T-type calcium channel blockers as neuroprotective agents

Contact Info

Product

Resources

About