Zonulin levels in complicated pregnancy: a systematic review and meta-analysis

Daneshvar, Mojtaba; Yadegari, Anahita; Ribaldone, Davide Giuseppe; Hasanzadeh, Mohaddeseh; Djafarian, Kurosh

doi:10.1080/01443615.2022.2114822

Cited by 5 publications

(6 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the literature, the relationships between ZO and various in ammatory and chronic diseases [5] have been evaluated, but our study is the rst to focus on PPROM patients. ZO levels did not signi cantly differ between the PPROM and control groups.…”

Section: Discussionmentioning

confidence: 99%

“…This leads to the activation of T cells, which can migrate to the intestine or various organs, causing systemic chronic in ammatory diseases such as celiac disease, irritable bowel syndrome, asthma, and chronic obstructive pulmonary disease [3]. ZO levels were also evaluated within the context of gynecological and obstetric diseases, and increased zonulin levels were observed in women with a diminished ovarian reserve, gestational diabetes mellitus and complicated pregnancies in previous studies [4,5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

WITHDRAWN: Is there an association between the serum zonulin concentration and the occurrence of PPROM?

Mert

2024

Preprint

View full text Add to dashboard Cite

Aim: This study aimedto evaluate the associationsbetween intestinal permeability andzonulin (ZO) levels and preterm premature membrane rupture (PPROM) in patients. Methods: A total of 44 pregnant women, 22 with PPROM and 22 in the control group, were included in this prospective case‒controlstudy. Venousblood samples and umbilical cord blood samples were taken from all participants after delivery. The blood samples were centrifuged at 3000 RPM for 10 minutes and stored at -80°C until biochemical analysis. Results: The median gestational age at delivery was 34 weeks (24-36 weeks). The median maternal blood ZO level (99.1 ng/mL [67.5-307.5] vs. 95.6 ng/mL [65.7-320.0], p = 0.925) and the cord blood ZO level (81.9 ng/mL [30.9-271.3] vs. 76.9 ng/mL [44.1-314.8], p = 0.681) were not different between the PPROM group and the control group. The demographic and clinical data revealeda significant correlation between maternal and fetal cord ZO levels and newborn birthweight in the PPROM group (r=0.607, p=0.003; r=0.617, p=0.002, respectively). A strong positive correlation was also found between the ZO levels in maternal serum (r: 0.837, p <0.001) and fetal cord blood (r: 0.944, p <0.001). Conclusion: No significant difference inmaternal serum/umbilical cord blood zonulin levels was detected between PPROM patientsand control patients. However, a positive correlation was found between newborn birthweight and maternal serum zonulin levels, as well as umbilical cord levels. In the PPROM patients, there was a positive correlation between maternal serum and fetal cord zonulin levels in all patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Is there an association between the serum zonulin concentration and the occurrence of PPROM?

Mert

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Zonulin levels did not differ in the treatment approach of patients with GDM, i.e., no significant difference in zonulin levels was observed between GDM patients who could be controlled by diet and those who required insulin therapy. In contrast to some studies showing that the association between zonulin levels and GDM is consistent, several studies have not confirmed this association [23]. These inconsistencies are thought to be due to studies conducted in different populations and in individuals of different ages.…”

Section: Discussionmentioning

confidence: 62%

Does Second Trimester Maternal Serum Zonulin Level Predict Gestational Diabetes Mellitus?

Tonyalı,

Arslan,

Sucu

et al. 2024

JCM

View full text Add to dashboard Cite

Zonulin, a protein that regulates intestinal permeability, has attracted attention as a potential biomarker for GDM. Therefore, this study aims to investigate whether there are differences in zonulin levels between the GDM group and control groups, especially between those receiving different treatments (diet and insulin). Based on this idea, we included 90 patients with a gestational age between 24 and 28 weeks in our study. While GDM was not detected in 33 of these patients, as a result of OGTT, 57 patients were diagnosed with GDM and these patients were followed throughout their pregnancy. Gestational diabetes was diagnosed by an OGTT performed between 24 and 28 weeks of gestation according to American Diabetes Association (ADA) standards. During follow-up, GDM patients were divided into two groups according to whether they required insulin treatment. Plasma zonulin levels were determined using enzyme-linked immunosorbent assay (ELISA) techniques. The GDM group had significantly higher plasma zonulin levels than the control group (p < 0.005). According to our research, zonulin may be a non-invasive biomarker involved in the etiology of GDM. Large-scale research on this topic is still needed.

show abstract

“…The association between zonulin levels and impaired glucose metabolism has also been described in patients with obesity [ 62 , 141 , 142 , 143 , 144 ] or insulin resistance associated with polycystic ovary syndrome (PCOS) [ 145 , 146 ]. Moreover, it has recently been shown that elevated levels of zonulin could be a potential predictor of complications related to pregnancy, including gestational diabetes (GDM), intrahepatic cholestasis (ICP), hypertensive disorders (HDP), and adverse perinatal outcomes [ 131 , 147 , 148 , 149 , 150 , 151 , 152 ].…”

Section: Diseases Associated With Altered Zonulin Levelsmentioning

confidence: 99%

Zonulin as a Potential Therapeutic Target in Microbiota-Gut-Brain Axis Disorders: Encouraging Results and Emerging Questions

Veres-Székely

Szász

Pap

et al. 2023

IJMS

View full text Add to dashboard Cite

The relationship between dysbiosis and central nervous diseases has been proved in the last 10 years. Microbial alterations cause increased intestinal permeability, and the penetration of bacterial fragment and toxins induces local and systemic inflammatory processes, affecting distant organs, including the brain. Therefore, the integrity of the intestinal epithelial barrier plays a central role in the microbiota–gut–brain axis. In this review, we discuss recent findings on zonulin, an important tight junction regulator of intestinal epithelial cells, which is assumed to play a key role in maintaining of the blood–brain barrier function. In addition to focusing on the effect of microbiome on intestinal zonulin release, we also summarize potential pharmaceutical approaches to modulate zonulin-associated pathways with larazotide acetate and other zonulin receptor agonists or antagonists. The present review also addresses the emerging issues, including the use of misleading nomenclature or the unsolved questions about the exact protein sequence of zonulin.

show abstract

Zonulin levels in complicated pregnancy: a systematic review and meta-analysis

Cited by 5 publications

References 41 publications

WITHDRAWN: Is there an association between the serum zonulin concentration and the occurrence of PPROM?

WITHDRAWN: Is there an association between the serum zonulin concentration and the occurrence of PPROM?

Does Second Trimester Maternal Serum Zonulin Level Predict Gestational Diabetes Mellitus?

Zonulin as a Potential Therapeutic Target in Microbiota-Gut-Brain Axis Disorders: Encouraging Results and Emerging Questions

Contact Info

Product

Resources

About