Zonulin, TNF-a and nitric oxide in the Ig E-dependent and Ig E-independent food allergy in children

Приходченко, Н. Г.

doi:10.26226/morressier.5afac50ad0241f0023ccc073

2018

DOI: 10.26226/morressier.5afac50ad0241f0023ccc073

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Zonulin, TNF-a and nitric oxide in the Ig E-dependent and Ig E-independent food allergy in children

Н. Г. Приходченко¹

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2019

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Molecular and genetic mechanisms of endothelial dysfunction in children with allergic enteropathy

Шуматова

Prihodchenko

Зернова

2019

Tihookeanskij medicinskij žurnal

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Objective. The objective is to analyze molecular and genetic mechanisms of endothelial dysfunction development in children with allergic enteropathy.Methods: We have studied the polymorphisms of endothelial nitric oxide synthase gene and the level of nitric oxide metabolites in coprofiltrates in 43 children aged from 6 months to 3 years with allergic enteropathy.Results: The endothelial dysfunction in allergic enteropathy is associated with nitric oxide molecule. Carriage of the homozygous allele СС Т786С of the endothelial nitric oxide synthase gene raises the risk of IgE-independent food allergy development by 8.8 times.Conclusions: The conducted study evidences the active participation of nitric-oxidergic mechanism in allergic inflammation development.

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Molecular and genetic mechanisms of endothelial dysfunction in children with allergic enteropathy

Шуматова

Prihodchenko

Зернова

2019

Tihookeanskij medicinskij žurnal

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Tight joints and zonulin in the formation of oral tolerance and food allergy

Приходченко

Шуматова

Grigorian

et al. 2019

Tihookeanskij medicinskij žurnal

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Summary: The study represents a review of publications covering molecular entity of intestinal permeability and changes causing its disorders. The current concepts on intestinal barrier, tight joints (TJ) and intestinal permeability under normal and pathological conditions are covered. Special attention has been given to molecular unions of tight joints; a role of dysregulation of the components of the TJ complex in the formation of oral tolerance and food allergy is disclosed. It is shown that the assessment of the intestinal epithelial barrier condition can be a significant diagnostic criterion to control the disease and to assess the effectiveness of treatment.

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Zonulin, TNF-a and nitric oxide in the Ig E-dependent and Ig E-independent food allergy in children

Cited by 2 publications

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Molecular and genetic mechanisms of endothelial dysfunction in children with allergic enteropathy

Molecular and genetic mechanisms of endothelial dysfunction in children with allergic enteropathy

Tight joints and zonulin in the formation of oral tolerance and food allergy

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