Zooming in and out of ferroptosis in human disease

Wang, Xue; Zhou, Ye; Wang, Fudi

doi:10.1007/s11684-023-0992-z

Cited by 41 publications

(21 citation statements)

References 337 publications

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“…Then, lipid radicals react with oxygen molecules to form a lipid peroxyl radical, which then reacts with nearby PUFAs to cause lipid peroxidation. This captures its hydrogen atoms and generates two new products called hydroperoxides and new lipid atomic groups, which lead to a chain reaction, generating many lipid peroxides, destroying the cell membrane, and causing ferroptosis [ 51 ]. 4-Hydroxynonenal (4-HNE) and malondialdehyde (MDA) are key biological biomarkers for verifying the occurrence of ferroptosis and lipid peroxidation.…”

Section: Mechanism Of Ferroptosismentioning

confidence: 99%

Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure

Zhang,

Luo,

et al. 2024

Eur J Med Res

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The progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor for important proteins such as hemoglobin, myoglobin, oxidative respiratory chain, and DNA synthetase, in the myocardial energy metabolism process. In recent years, numerous studies have shown that HF is associated with iron dysmetabolism, and deficiencies in iron and overload of iron can both lead to the development of various myocarditis diseases, which ultimately progress to HF. Iron toxicity and iron metabolism may be key targets for the diagnosis, treatment, and prevention of HF. Some iron chelators (such as desferrioxamine), antioxidants (such as ascorbate), Fer-1, and molecules that regulate iron levels (such as lactoferrin) have been shown to be effective in treating HF and protecting the myocardium in multiple studies. Additionally, certain natural compounds can play a significant role by mediating the imbalance of iron-related signaling pathways and expression levels. Therefore, this review not only summarizes the basic processes of iron metabolism in the body and the mechanisms by which they play a role in HF, with the aim of providing new clues and considerations for the treatment of HF, but also summarizes recent studies on natural chemical components that involve ferroptosis and its role in HF pathology, as well as the mechanisms by which naturally occurring products regulate ferroptosis in HF, with the aim of providing reference information for the development of new ferroptosis inhibitors and lead compounds for the treatment of HF in the future.

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Section: Mechanism Of Ferroptosismentioning

confidence: 99%

Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure

Zhang,

Luo,

et al. 2024

Eur J Med Res

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“…With the rapid development of techniques and methods, a series of key regulatory genes and pathways related to ferroptosis have been identified. In general, the three basic characteristics of ferroptosis are the accumulation of Fe 2+ , PL peroxidation, and imbalance of antioxidant system [ 5 ]. Therefore, we summarize the regulatory network of ferroptosis around three factors: iron metabolism, lipid metabolism, and antioxidant system.…”

Section: The Mechanisms Of Ferroptosismentioning

confidence: 99%

“…This result may be associated with the HO-1 mediated-enhancement of glutathione peroxidase 4 (GPX4) activity [ 35 ]. There are four main destinations of Fe 2+ in LIP [ 5 , 7 ]: (1) Fe 2+ is exported to extracellular space through FPN; (2) Fe 2+ is used in the synthesis of iron-containing proteins; (3) Fe 2+ binds to ferritin through the iron chaperone poly (rC) -binding protein 1 (PCBP1); and (4) Fe 2+ enters mitochondria via SLC25A28/37 for heme, mitochondrial ferritin, and iron-sulfur (Fe-S) clusters synthesis. Two pathways mainly regulate the intracellular iron metabolism [ 32 ].…”

Section: The Mechanisms Of Ferroptosismentioning

confidence: 99%

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Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Wu,

Zhu,

Liu

et al. 2024

Antioxidants

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Ferroptosis is an emerging type of regulated cell death usually accompanied by the accumulation of ferrous ions (Fe2+) and lipid peroxides. As the metabolic hub of the body, the liver is crucial for iron storage and lipid metabolism. The liver seems to be closely related to ferroptosis through iron and lipid metabolism. Liver disease greatly threatens host health, and exploring effective interventions is essential. Mounting studies have demonstrated that ferroptosis is one of the possible pathogenic mechanisms involved in liver disease. Targeting ferroptosis may provide a promising opportunity for treating liver disease. However, drugs targeting ferroptosis are extremely limited. Therefore, it is an urgent need to develop new and safe ferroptosis regulators. Natural active compounds (NAC), especially those derived from traditional Chinese medicine, have recently shown great therapeutic potential in liver disease via modulating ferroptosis-related genes or pathways. Here, we outline the molecular mechanism of ferroptosis and systematically summarize the regulatory function of NAC on ferroptosis in liver disease. Finally, we discuss the application prospects and potential problems concerning NAC as ferroptosis regulators for managing liver disease.

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“…In about ten years of research investigations, ferroptosis emerged as a type of cell death with a pivotal role in preventing or even facilitating the progression of many diseases (reviewed in [ 1 , 2 , 3 ]). In particular, ferroptosis is now considered a good therapeutic option to treat multiple forms of cancer and arrest tumor growth [ 3 , 4 , 5 ], as well as a causal factor in neurodegenerative disorders [ 6 ], senescence/aging [ 7 ], different blood diseases [ 8 ], and kidney- and ischemia-reperfusion injuries [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors

Punziano,

Trombetti,

Cesaro

et al. 2024

Antioxidants

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Ferroptosis is a type of programmed cell death that differs from apoptosis, autophagy, and necrosis and is related to several physio-pathological processes, including tumorigenesis, neurodegeneration, senescence, blood diseases, kidney disorders, and ischemia–reperfusion injuries. Ferroptosis is linked to iron accumulation, eliciting dysfunction of antioxidant systems, which favor the production of lipid peroxides, cell membrane damage, and ultimately, cell death. Thus, signaling pathways evoking ferroptosis are strongly associated with those protecting cells against iron excess and/or lipid-derived ROS. Here, we discuss the interaction between the metabolic pathways of ferroptosis and antioxidant systems, with a particular focus on transcription factors implicated in the regulation of ferroptosis, either as triggers of lipid peroxidation or as ferroptosis antioxidant defense pathways.

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Zooming in and out of ferroptosis in human disease

Cited by 41 publications

References 337 publications

Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure

Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors

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