Zooming in on Butyrate-Producing Clostridial Consortia in the Fermented Grains of Baijiu via Gene Sequence-Guided Microbial Isolation

Chai, Li‐Juan; Lü, Zhen-Ming; Zhang, Xiaojuan; Ma, Jian; Xu, Pengwei; Qian, Wei; Chen, Xiao; Wang, Songtao; Shen, Caihong; Shi, Jin‐Song; Xu, Zhenghong

doi:10.3389/fmicb.2019.01397

Cited by 49 publications

(32 citation statements)

References 45 publications

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“…Bacilli, Clostridia and Alphaproteobacteria were the dominant classes from sample to sample. These results are similar with the study of [38] who also obtained Bacilli and Clostridia on fermented baiju seeds. The dominance of these classes is due to the fact that they contain bacteria capable of sporulating and growing in an acidic environment.…”

Section: Discussionsupporting

confidence: 92%

Bacterial Community Diversity of Fermented Pepper in Brazzaville Revealed by Illumina Miseq of 16S rRNA Gene

Boumba¹,

Lebonguy²,

Goma-Tchimbakala³

et al. 2021

FNS

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Fermented foods play an important role in the daily life and diet of the populations in Congo. Among these fermented foods, there is Pilipili or fermented pepper which is consumed without prior cooking. The microorganisms present are eaten alive. Few studies have been carried out on these microorganisms which may have beneficial effects on health. This study aimed to investing taxonomic diversity of bacterial communities in 3 samples of fermented peppers produced in 3 distinct areas of Brazzaville. To do this investigation, Illumina Miseq sequencing of 16S rRNA gene was used. The results showed that the number of identified operational taxonomic units (OTUs) ranged from 156 to 392. All OTUs belong to the domain of Bacteria and could be categorized into 21 Phyla, 36 Classes, 58 Orders, 100 Families and 171 genera. Firmicutes and Proteobacteria were the main dominant phyla of the total phyla present with a relative abundance of 89.12% and 8.08%, respectly. At the class level, Bacili were dominant in EB1 (99.50%), EB3 (85.32%) and EB2 (42.29%) while Clostridia in EB2 (40.10%). Lactobacillus, Clostridium sensu stricto and Frutobacillus were the dominant genera in the sample EB1, EB2 and EB3, respectively. The hierarchical classification showed that the samples EB1 and EB2 form the same group and EB3 is unique. Principal component analysis showed that the younger EB3 and EB2 samples were more diverse than the older EB1 sample. This study is a first in Congo on the diversity of fermented pepper using Illumina Miseq. It has shown that this food is very diverse and can be a source for the isolation of bacteria with biotechnological potential.

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Section: Discussionsupporting

confidence: 92%

Bacterial Community Diversity of Fermented Pepper in Brazzaville Revealed by Illumina Miseq of 16S rRNA Gene

Boumba¹,

Lebonguy²,

Goma-Tchimbakala³

et al. 2021

FNS

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“…Reduced acetic acid levels might be due to minocycline treatment that decreased acetate-producing bacteria, such as Lactobacillus . Likewise, minocycline-induced reduction in butyric acid is possibly related to its inhibition of the growth of butyrate-producing microbes, such as class Bacilli and genus Ruminococcus [ 35 ]. Additionally, both acetic acid and butyric acid are ligands for GPR41, which has a BP-lowering effect [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Altered Gut Microbiota and Its Metabolites in Hypertension of Developmental Origins: Exploring Differences between Fructose and Antibiotics Exposure

Hsu

Chan

et al. 2021

IJMS

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Gut microbiota-derived metabolites, in particular short chain fatty acids (SCFAs) and their receptors, are linked to hypertension. Fructose and antibiotics are commonly used worldwide, and they have a negative impact on the gut microbiota. Our previous study revealed that maternal high-fructose (HF) diet-induced hypertension in adult offspring is relevant to altered gut microbiome and its metabolites. We, therefore, intended to examine whether minocycline administration during pregnancy and lactation may further affect blood pressure (BP) programmed by maternal HF intake via mediating gut microbiota and SCFAs. Pregnant Sprague-Dawley rats received a normal diet or diet containing 60% fructose throughout pregnancy and lactation periods. Additionally, pregnant dams received minocycline (50 mg/kg/day) via oral gavage or a vehicle during pregnancy and lactation periods. Four groups of male offspring were studied (n = 8 per group): normal diet (ND), high-fructose diet (HF), normal diet + minocycline (NDM), and HF + minocycline (HFM). Male offspring were killed at 12 weeks of age. We observed that the HF diet and minocycline administration, both individually and together, causes the elevation of BP in adult male offspring, while there is no synergistic effect between them. Four groups displayed distinct enterotypes. Minocycline treatment leads to an increase in the F/B ratio, but decreased abundance of genera Lactobacillus, Ruminococcus, and Odoribacter. Additionally, minocycline treatment decreases plasma acetic acid and butyric acid levels. Hypertension programmed by maternal HF diet plus minocycline exposure is related to the increased expression of several SCFA receptors. Moreover, minocycline- and HF-induced hypertension, individually or together, is associated with the aberrant activation of the renin–angiotensin system (RAS). Conclusively, our results provide a new insight into the support of gut microbiota and its metabolite SCAFs in the developmental programming of hypertension and cast new light on the role of RAS in this process, which will help prevent hypertension programmed by maternal high-fructose and antibiotic exposure.

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“…A study correlated a butyrate-producing bacteria in the feces of patients with ACP, suggesting that microbial metabolites may contribute to ACP conversion to CRC [ 86 ]. A few members of the Clostridium genus (butyrate-producing bacteria) are capable of metabolizing primary bile acids into secondary bile acids [ 87 , 88 ]. These bile acids proved to have a contribution in ACP conversion to CRC by affecting the host’s metabolism and immunity [ 89 , 90 , 91 ].…”

Section: Pro and Prebiotic In Human Healthmentioning

confidence: 99%

An Overview of Gut Microbiota and Colon Diseases with a Focus on Adenomatous Colon Polyps

Pop

Vodnar

Diaconeasa

et al. 2020

IJMS

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It is known and accepted that the gut microbiota composition of an organism has an impact on its health. Many studies deal with this topic, the majority discussing gastrointestinal health. Adenomatous colon polyps have a high prevalence as colon cancer precursors, but in many cases, they are hard to diagnose in their early stages. Gut microbiota composition correlated with the presence of adenomatous colon polyps may be a noninvasive and efficient tool for diagnosis with a high impact on human wellbeing and favorable health care costs. This review is meant to analyze the gut microbiota correlated with the presence of adenomatous colon polyps as the first step for early diagnosis, prophylaxis, and treatment.

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Zooming in on Butyrate-Producing Clostridial Consortia in the Fermented Grains of Baijiu via Gene Sequence-Guided Microbial Isolation

Cited by 49 publications

References 45 publications

Bacterial Community Diversity of Fermented Pepper in Brazzaville Revealed by Illumina Miseq of 16S rRNA Gene

Bacterial Community Diversity of Fermented Pepper in Brazzaville Revealed by Illumina Miseq of 16S rRNA Gene

Altered Gut Microbiota and Its Metabolites in Hypertension of Developmental Origins: Exploring Differences between Fructose and Antibiotics Exposure

An Overview of Gut Microbiota and Colon Diseases with a Focus on Adenomatous Colon Polyps

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