We propose a scenario with string theory in the deep ultraviolet, an intermediate asymptotically safe scaling regime for gravity and matter, and the Standard Model in the infrared. This could provide a new perspective to tackle challenges of the two models: For instance, the gravitational Renormalization Group flow could connect a negative microscopic to a positive macroscopic cosmological constant, potentially rendering string theory on an anti-de Sitter background observationally viable. Further, the unitarity of a string-theoretic ultraviolet completion could be inherited by an asymptotically safe fixed point, despite the presence of higher-order interactions. We discuss necessary conditions on the scale of asymptotic safety and the string scale for our scenario to be viable. As a first test, we explore the weak-gravity conjecture in the context of asymptotically safe gravity.