Zoon's balanitis (balanitis circumscripta plasmacellularis)

Souteyrand, P.; Wong, Elizabeth; Macdonald, D.M.

doi:10.1111/j.1365-2133.1981.tb01205.x

Cited by 76 publications

(50 citation statements)

References 7 publications

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“…Subsequently similar lesions have been described on the vulva23 and the lips.4 This rare disorder consists of a single, red, shiny and smooth patch involving the glans penis or adjacent prepuce or both.' [5][6][7] The characteristic histological features are: a band-like mainly plasmacytic inflammatory infiltrate of the upper dermis, dilated capillaries and deposits of haemosiderin.' 5Treatment with topical steroids8 is palliative at best, with many patients being totally unresponsive.679 Circumcision which was advocated as the best modality of treatment many decades ago has been reported to be beneficial in the recent reports6 7 10 We report 32 cases with this condition 27 of whom were treated successfully with circumcision.…”

Section: Introductionmentioning

confidence: 99%

Plasma cell balanitis: clinical and histopathological features--response to circumcision.

Kumar

Sharma

Rajagopalan

et al. 1995

Sexually Transmitted Infections

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Section: Introductionmentioning

confidence: 99%

Plasma cell balanitis: clinical and histopathological features--response to circumcision.

Kumar

Sharma

Rajagopalan

et al. 1995

Sexually Transmitted Infections

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“…This rare disorder seen almost exclusively in uncircumcised men has been described as ‘balanoposthite chronique circonscrite bénigne à plasmocytes’ by Zoon in 1952 [2]. According to Souteyrand et al [3], it manifests itself with a solitary asymptomatic circumscribed shiny glazed orange-coloured macular erythema with a maximun diameter of 3 cm. Histology shows a thinned and flattened epidermis and a dense band-like infiltrate in the upper dermis, in which plasma cells usually exceed 50% of the cells present.…”

Section: Discussionmentioning

confidence: 99%

Review of 120 Biopsies Performed on the Balanopreputial Sac

Alessi¹,

Coggi²,

Gianotti³

2004

Dermatology

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Background: Long-lasting erythematous lesions involving the balanopreputial sac may be clinically difficult to classify, and biopsies may be performed in order to clarify the nature of the disease. However, our previous experience led us to consider several cases as histopathologically unclassifiable. Objective: To establish the causes of such unsatisfactory findings. Methods: We reviewed 120 balanopreputial sac biopsies performed at the surgical unit of our institute from January 1999 to December 2002 examining also the patients’ clinical records. Results: We found that a small group of previously unclassified cases showed common clinical and histopathological features. Clinically, all patients were uncircumcised and had long-lasting asymptomatic erythematous plaques on the balanopreputial sac with no erythroplastic or lichenoid features and no correlation with sexual intercourse. Histologically, all specimens showed a thinned and spongiotic epithelium, a band-like infiltrate of lymphocytes and histiocytes with a variable number of plasma cells in the upper part of the chorion and further signs of acute, subacute or chronic inflammation. Conclusions: In our view, these cases fall within a spectrum of inflammatory non-cicatricial disorders, ranging from almost pure lymphohistiocytic forms to forms which fulfil all criteria to be classified as balanitis circumscripta plasmacellularis of Zoon. We propose to classify these cases histologically as inflammatory non-cicatricial balanoposthitis and clinically as idiopathic inflammatory non-cicatricial balanoposthitis.

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“…Histologically, epidermal edema, a dense upper dermal band of chronic inflammatory cells, including many plasma cells, dilated capillaries, extravasated red blood cells, and hemosiderin deposition, is observed [23]. However, it has been suggested that the presence of plasma cell infiltrate is relatively not specific for the diagnosis of PCVZ [22,24]. Recently, reflectance confocal microscopy, an in vivo imaging method to get morphological information about architecture and single cells in the skin, was shown to be helpful in differentiating between balanitis and carcinoma in situ and avoiding biopsies at this sensitive site [25].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Efficacy of Topical Calcineurin Inhibitors in Plasma Cell Balanitis: Case Series and Review of the Literature

Kyriakou¹,

Patsatsi²,

Patsialas

et al. 2014

Dermatology

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Plasma cell balanitis of Zoon (PCBZ) and plasma cell vulvitis (PCV) are characterized as idiopathic, benign, chronic irritant mucositis. The clinical symptoms and signs usually persist or reappear after treatment withdrawal. Therefore, many therapies have been tried and are available. Recently, several reports of PCBZ and PCV treated with calcineurin inhibitors, tacrolimus and pimecrolimus, have been reported in the literature. We present 9 cases of PCBZ treated with tacrolimus 0.1% ointment (Protopic, Toyama, Japan) that showed good therapeutic results within 4 weeks of treatment, and we review the literature of PCBZ and PCV and their response to these topical immunomodulators. Based on the current literature and on the anecdotal experience, we believe that topical calcineurin inhibitors may serve as a therapeutic option in recalcitrant plasma cell balanitis and vulvitis.

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Zoon's balanitis (balanitis circumscripta plasmacellularis)

Cited by 76 publications

References 7 publications

Plasma cell balanitis: clinical and histopathological features--response to circumcision.

Plasma cell balanitis: clinical and histopathological features--response to circumcision.

Review of 120 Biopsies Performed on the Balanopreputial Sac

Therapeutic Efficacy of Topical Calcineurin Inhibitors in Plasma Cell Balanitis: Case Series and Review of the Literature

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