Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway

Jõgi, Nils Oskar; Svanes, Cecilie; Siiak, Silver Peeter; Logan, Erin; Holloway, John W.; Igland, Jannicke; Johannessen, Ane; Levin, Michael; Real, Francisco Gómez; Schlünssen, Vivi; Horsnell, William; Bertelsen, Randi J.

doi:10.1111/cea.13055

Cited by 25 publications

(24 citation statements)

References 58 publications

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“…in endemic regions . Although data about Ascaris prevalence in the Nordic countries are limited, the exposure to Ascaris can be quite high in these regions, with 29% in the Bergen ECRHS III cohort . In the light of extremely low findings of HDM and HDM mite allergens in bedroom mattress samples, identifying cross‐reactive proteins of other causes is relevant for future research into the cause of allergies and sensitization to mites.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of allergic sensitization to storage mites in Northern Europe

Jõgi

Olsen

Svanes

et al. 2019

Clin Experimental Allergy

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Background Allergic sensitization to storage mites has mostly been related to occupational exposures like farming, grain/cattle handling, whereas for non‐occupational settings, storage mite sensitization has been attributed to cross‐reactivity with house dust mite (HDM) allergens. Objective We aimed to describe the prevalence of allergic sensitization to storage mites, co‐sensitization to HDM allergens and respiratory symptoms in Denmark, Iceland, Norway and Sweden. Methods The population comprised of 1180 participants born 1945‐1972 of the third follow‐up of the population‐based cohort European Community Respiratory Health Survey (ECRHS) in Aarhus, Bergen, Reykjavik and Uppsala. A clinical examination included skin prick tests (SPT) to Lepidoglyphus destructor, Tyrophagus putrescentiae, Acarus siro and common inhalant allergens, as well as standardized interviews. Results 8% were sensitized to HDM and 10% to storage mite, with some variation by study centre: Reykjavik 13%, Bergen 8% and Aarhus 7%. In Uppsala, only L destructor (3%) was measured. Storage mite sensitization was higher among men (11%) than women (8%). Among storage mite sensitized, 44% were also sensitized to HDM. Storage mite sensitization was associated with asthma and nasal allergies, but not with age, education, pet keeping or place of upbringing. Conclusions and Clinical Relevance In this Northern European population‐based study, allergic sensitization to storage mite was as common as HDM sensitization. Storage mite sensitization was, independently of HDM sensitization, associated with respiratory symptoms and asthma. Our findings suggest that storage mite sensitization should be evaluated with regard to inclusion into the common inhalant allergen panel in Northern Europe.

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Section: Discussionmentioning

confidence: 99%

Prevalence of allergic sensitization to storage mites in Northern Europe

Jõgi

Olsen

Svanes

et al. 2019

Clin Experimental Allergy

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“…Several parasitic molecules have been implicated in modulating the immune and allergic response of helminth-infected hosts [ 27 ]. It has been described that parasite infections can develop a strong response and high levels of IgE in allergic sufferers, i.e., asthma or tropical pulmonary eosinophilia [ 28 , 29 , 30 , 31 ]. Moreover, it seems that infections by A. lumbricoides, T. canis, T. trichiura , hookworm, and S. mansoni can cause allergic reactions in humans [ 15 , 16 , 17 , 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Dirofilaria immitis Could Be a Risk Factor for the Development of Allergic Diseases in Humans

Montoya-Alonso

Morchón

Matos

et al. 2020

Animals

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The Canary Islands are hyperendemic for canine heartworm and the risk of zoonotic infection is high. Additionally, there is evidence of development of allergies due to nematode infections in animals and humans. Since the population of the Canary Islands presents high prevalence of allergic comorbidities, and previous studies have shown a possible relationship between allergies and seropositivity to heartworm, the aim was to evaluate whether exposure to heartworm may contribute to the development of allergies in the human population. First, an epidemiological study was conducted on 248 owners of dogs with/without heartworm infection in the Canary Islands. Secondly, a serological analysis of the presence of total IgE and specific IgE against heartworm was conducted in 66 samples of inhabitants of the Canary Islands. The survey showed that allergic owners had heartworm-positive dogs more frequently (p < 0.01). Of the analyzed human samples, 43.9% were seropositive to heartworm and Wolbachia. Total IgE concentrations were increased in 34.5% seropositive samples and 8.1% seronegative samples. Specific IgE against heartworm was only found in human seropositive samples (17.2%). Contact with heartworm may be a risk factor for the development of allergic diseases, although further studies to elucidate the relationship between heartworm and allergies should be carried out.

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“…This indicates that disease activity might induce changes that are transmissible to the next generation, possibly explained by epigenetic inheritance rather than by shared environment or genetics alone [94]. Furthermore, a study by Jogi et al of helminths and allergies in two generations in Norway found that fathers' Toxocara exposure was associated with daughters' allergies, and mother's Toxocara exposure with sons' allergies [81]. The sex-specific pattern might be suggestive of epigenetic transmission.…”

Section: Evidence For Transmission Across Generations In Asthma and Amentioning

confidence: 99%

“…might be a risk factor for atopic disease. Epidemiological data suggested that this risk might be associated with paternal exposure to these parasites [81].…”

Section: Maternal Pre-conception Environment and Long Lasting Influenmentioning

confidence: 99%

Environmental Impact on Health across Generations: Policy Meets Biology. A Review of Animal and Human Models

et al. 2018

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Intrauterine and early life has been accepted as important susceptibility windows for environmental exposure and disease later in life. Emerging evidence suggests that exposure before conception may also influence health in future generations. There has been little research on human data to support this until now. This review gives evidence from epigenetic as well as immunologic research, and from animal as well as human models, supporting the hypothesis that there may be important susceptibility windows before conception in relation to exposure such as obesity, diet, smoking and infections. It is likely that we can identify vulnerability windows in men and women in which interventions may have an impact on several generations in addition to individual health. Establishing vulnerability windows affecting health over future generations, and not only in the now or the near future of the individual, may provide tremendous opportunities for health policy and practice.

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Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway

Abstract: SummaryBackground: Animal and human studies indicate that definitive host helminth infec-

Cited by 25 publications

References 58 publications

Prevalence of allergic sensitization to storage mites in Northern Europe

Prevalence of allergic sensitization to storage mites in Northern Europe

Dirofilaria immitis Could Be a Risk Factor for the Development of Allergic Diseases in Humans

Environmental Impact on Health across Generations: Policy Meets Biology. A Review of Animal and Human Models

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