Zoonotic helminth infections with particular emphasis on fasciolosis and other trematodiases

Robinson, Mark W.; Dalton, John P.

doi:10.1098/rstb.2009.0089

Cited by 149 publications

(119 citation statements)

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“…Future control programmes for human echinococcosis are also likely to depend on the reduction of transmission of the parasite from animals to humans (Robinson and Dalton, 2009). Echinococcosis has long been considered to be an eradicable disease and eradication of Echinococcus granulosus infections has been achieved in several countries/regions including Iceland, Tasmania, New Zealand, Cyprus and the Falkland Islands as a result of concerted efforts in the field and long-term political support (Jenkins et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Estimated annual economic loss from organ condemnation, decreased carcass weight and milk yield due to bovine hydatidosis (<em>Echinococcus granulosus</em>, Batsch, 1786) in Ethiopia

Fromsa¹,

Jobre²

2012

Ethiop. Vet. J.

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Post-slaughter survey data collected over a period of 15 years (1985)(1986)(1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999) by the Faculty of Veterinary Medicine (FVM), Addis Ababa University (AAU) were used as a basis for the analysis of estimation of the economic significance of bovine hydatidosis in Ethiopia. The analysis output revealed a 35.15% mean annual prevalence of bovine hydatidosis. The total estimated economic loss from organ condemnation, carcass weight and milk yield decrease amounts to 1,691,266,200 ETB (101,203,734 USD). This is equivalent to a loss of 475.40 ETB (28.45 USD) per every infected slaughtered cattle and 249.00 ETB (14.90 USD) per every infected milking cow. The results of the present study showed that hydatidosis is a highly prevalent cattle disease in Ethiopia with considerable direct and indirect economic losses. The magnitude of loss per infected subject warrants the need to mount an integrated nation-wide hydatidosis control program involving public education, canine health care, proper handling and disposal of infected organs, stray dog population management and institution of strict standard operating procedures (SOPs) in slaughterhouses and public health legislative reinforcements. The authors recommend that hydatidosis control program should be designed and implemented in the context on 'One Health' initiative by integrating it with other zoonotic disease control program and in partnerships with animal and public health actors as well as other relevant stakeholders. .

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Section: Introductionmentioning

confidence: 99%

Estimated annual economic loss from organ condemnation, decreased carcass weight and milk yield due to bovine hydatidosis (<em>Echinococcus granulosus</em>, Batsch, 1786) in Ethiopia

Fromsa¹,

Jobre²

2012

Ethiop. Vet. J.

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“…Cercariae and metacercariae are the infestant stage of zoonotic trematodes, and upon ingestion or penetration, they grow into a juvenile worm [20]. Alternative infestation modes have being reported [6] in places where row meat consumption is common, accidental ingestion of juvenile/adult flukes can occur, a phenomenon known as paratenic trematodiasis [7].…”

Section: Farm Animals Diseases Recent Omic Trends and New Strategiesmentioning

confidence: 99%

“…Neglected emerging diseases cause around 75% of human infectious diseases worldwide [7,8]. Parasitic zoonosis, include protozoans and helminths, such as nematodes, cestodes, and trematodes, some of which, exhibit very complex life cycles that require invertebrate vectors that may look as innocuous as a garden snail but instead could be extremely dangerous vectors of very serious and debilitating parasitic diseases.…”

Section: Farm Animals Diseases Recent Omic Trends and New Strategiesmentioning

confidence: 99%

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Zoonotic Trematodiasis

Miranda-Miranda¹

2018

Farm Animals Diseases, Recent Omic Trends and New Strategies of Treatment

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Parasitic zoonoses are diseases caused by parasites shared between animal hosts and humans. Most of parasitic zoonoses are considered as neglected because of the absence of campaigns destined to prevention control and treatment of these diseases in most developed and undeveloped nations, ignoring that parasitic zoonoses affect almost half of the world human population and the vast majority of livestock worldwide is at risk of acquiring or sick because of a zoonotic disease. Zoonotic trematodiasis are numerous in almost every nation and responsible for serious and debilitating helminthic diseases in about 75 million people as well as the billions of dollars in production losses to the livestock industry. The perspective of global warming, habitat loss and new host range adaptation indicates that unless a new approach based in genomics, transcriptomics and proteomics assessment of new biomarkers and anthelmintic targets is achieved, the incidence of zoonotic trematodiasis will increase for both human and animal hosts.

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“…infect over 200 million people and are second only to the malarial parasites in terms of number of humans killed globally each year [1,4,5]. Many of these parasitic infections are zoonotic, being passed to humans from domestic animals [6]. 4 To date, there are no effective vaccines for helminth infections and treatment relies entirely on chemotherapy.…”

Section: Introduction: the Need For New Drugs To Combat Helminth Infementioning

confidence: 99%

Metabolic enzymes of helminth parasites: potential as drug targets

Timson¹

2015

CPPS

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Metabolic pathways which extract energy from carbon compounds are essential for an organism's survival. Therefore, inhibition of enzymes in these pathways represents a potential therapeutic strategy to combat parasitic infections. However, the high degree of similarity between host and parasite enzymes makes this strategy potentially difficult. Nevertheless, several existing drugs to treat infections by parasitic helminths (worms) target metabolic enzymes. These include the trivalent antimonials which target phosphofructokinase and Clorsulon which targets phosphoglycerate mutase and phosphoglycerate kinase. Glycolytic enzymes from a variety of helminths have been characterised biochemically, and some inhibitors identified. To date none of these inhibitors have been developed into therapies. Many of these enzymes are externalised from the parasite and so are also of interest in the development of potential vaccines. Less work has been done on tricarboxylic acid cycle enzymes and oxidative phosphorylation complexes. Again, while some inhibitors have been identified none have been developed into drug-like molecules. Barriers to the development of novel drugs targeting metabolic enzymes include the lack of experimentally determined structures of helminth enzymes, lack of direct proof that the enzymes are vital in the parasites and lack of cell culture systems for many helminth species. Nevertheless, the success of Clorsulon (which discriminates between highly similar host and parasite enzymes) should inspire us to consider making serious efforts to discover novel anthelminthics which target metabolic enzymes.

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Zoonotic helminth infections with particular emphasis on fasciolosis and other trematodiases

Cited by 149 publications

References 123 publications

Estimated annual economic loss from organ condemnation, decreased carcass weight and milk yield due to bovine hydatidosis (<em>Echinococcus granulosus</em>, Batsch, 1786) in Ethiopia

Estimated annual economic loss from organ condemnation, decreased carcass weight and milk yield due to bovine hydatidosis (<em>Echinococcus granulosus</em>, Batsch, 1786) in Ethiopia

Zoonotic Trematodiasis

Metabolic enzymes of helminth parasites: potential as drug targets

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