Zoonotic<i>Mycobacterium bovis</i>–induced Tuberculosis in Humans

Müller, Borna; Dürr, Salome; Alonso, Silvia; Hattendorf, Jan; Laisse, Cláudio João Mourão; Parsons, Sven D.C.; Helden, Paul D. van; Zinsstag, Jakob

doi:10.3201/eid1906.120543

Cited by 340 publications

(320 citation statements)

References 24 publications

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“…Bacilli in this group are 99.9% genetically similar at the nucleotide level with identical 16S rRNA sequences (Boddinghaus et al, 1990;Sreevatsan et al, 1997) (O'Reilly and Daborn, 1995;Blischak et al, 2015). The proportion of cases due to M. bovis in humans in the last two decades has been variable, ranging from 0.5 to 13% depending on the study population, and it is estimated that nearly 10 million people are affected by tuberculosis worldwide every year (Müller et al, 2013;Olea-Popelka et al, 2017;PereaRazo et al, 2017). Transmission to humans occurs by inhalation of infectious droplets from infected cattle, and consumption of contaminated unpasteurized dairy products (de la .…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity of Mycobacterium bovis in Jalisco, Mexico: Tracing back sources of infection

GonzÃ¡lez-Ruiz¹,

Sosa-Gallegos²,

RodrÃguez-HernÃ¡ndez³

et al. 2018

J. Vet. Med. Anim. Health

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Bovine tuberculosis (bTB) is a disease of cattle that presents risk to public health, causing severe economic losses to the livestock industry and difficulty in eradication because of its complex epidemiology. The aim of this study was to identify relationships between Mycobacterium bovis strains from cattle in the State of Jalisco, and those of other States of México. Molecular fingerprints of 337 M. bovis isolates from Jalisco, and 1152 from other States of México were included in the study. Isolates were obtained from tubercles between 1997 and 2015. Evolutionary relationship was determined throughout spoligoforest (www.emi.unsw.edu.au/spoltools/). From 337 isolates from Jalisco, 59 spoligotypes were obtained, ten of them included 48% of all isolates in the state. Five spoligotypes were common to beef and dairy cattle. The molecular analysis showed eight clusters in a philogenetic three: one with three subclusters of nine isolates each, all from dairy cattle; four with two isolates, including dairy and beef cattle. All spoligotypes from Jalisco have been reported in other states, four of the most frequent ones: SB0673, SB0971, SB0669 and SB0140, were the same as in other states. The most frequent spoligotypes of M. bovis found in Jalisco were also the most frequent ones in other parts of Mexico. However, there is no evidence to conclude that Jalisco is the source of infection to other states since no information on movement and destination of cattle could be documented.

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Section: Introductionmentioning

confidence: 99%

Genetic diversity of Mycobacterium bovis in Jalisco, Mexico: Tracing back sources of infection

GonzÃ¡lez-Ruiz¹,

Sosa-Gallegos²,

RodrÃguez-HernÃ¡ndez³

et al. 2018

J. Vet. Med. Anim. Health

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“…Aunque M. tuberculosis es el agente etiológico más frecuente de la tuberculosis humana, ésta también puede ser producida por M. bovis; de ahí la importancia en el conocimiento de la distribución de éste patógeno en el ganado, así como la identificación de otros posibles reservorios en Colombia, con el fin de contribuir a las políticas de salud pública en el país; teniendo en cuenta que se han descrito varios casos de tuberculosis humana causada por M. bovis y M. bovis multirresistente en pacientes infectados con VIH en el mundo (2).…”

Section: Introductionunclassified

First approach to molecular epidemiology of bovine tuberculosis in Colombia

Jojoa-Jojoa

et al. 2016

Rev MVZ Córdoba

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Objective. To investigate the presence of Mycobacterium bovis and other Mycobacterium species in samples of cattle and buffalo in Colombia, to start the molecular characterization of M. bovis in the country. Material and methods. 492 samples were collected from herds identified with the presence of infected animals through the PPD, by the Group of Bovine Tuberculosis ICA Colombian Agricultural Institute in eight departments of Colombia. Lymph nodes of head, thorax and abdomen, gross lesions of tissues with tuberculosis, nasal swabs, milk, blood and fresh cheeses were included. Samples were subjected to detection of Mycobacterium bovis and other mycobacteria by conventional microbiological analysis and PCR-6110 and spoligotyping molecular assays. Results. In the samples analyzed especially in lymph nodes, Mycobacterium bovis was demonstrated with genotypes reported and not previously reported in the world, as well as M. tuberculosis in Antioquia, Cundinamarca, Boyacá and Magdalena departments. Conclusions. In Colombia there are at least 7 genotypes of M. bovis that are infected and sick cattle and buffalo from four different departments becoming serious threat to public health.Key words: Bovine tuberculosis, Mycobacterium bovis, diagnostic, molecular epidemiology, zoonosis (Sources: DeSC, MeSH). RESUMENObjetivo. Investigar la presencia de Mycobacterium bovis y otras especies de Mycobacterium en muestras de ganado bovino y búfalino en Colombia e iniciar la caracterización molecular de M. bovis en el país. Materiales y métodos. 492 muestras fueron recogidas de hatos identificados con presencia de animales infectados a través de la prueba de PPD, por el Grupo de Tuberculosis Bovina del Instituto Colombiano Agropecuario ICA en ocho departamentos de Colombia. Se incluyeron ganglios linfáticos de cabeza, tórax y abdomen, tejidos con lesiones macroscópicas de tuberculosis, hisopos nasales, leche, sangre y quesos frescos. Las muestras se sometieron a investigación de Mycobacterium bovis y otras micobacterias mediante el análisis microbiológico convencional y pruebas moleculares de PCR-IS6110 y spoligotyping. Resultados. En las muestras analizadas especialmente en los ganglios linfáticos, se evidenció Mycobacterium bovis con genotipos reportados y no reportados previamente en el mundo, así como M. tuberculosis en los departamentos de Antioquia, Cundinamarca, Magdalena y Boyacá. Conclusiones. En Colombia existen al menos 7 genotipos de M. bovis que se encuentran infectando y enfermando a bovinos y bufalinos de cuatro diferentes departamentos del país constituyéndose en seria amenaza para la salud pública. INTRODUCCIÓNMycobacterium bovis, agente causal de la tuberculosis en el ganado, es también un patógeno para gran número de animales como los felinos silvestres, animales domésticos y primates humanos y no humanos, entre otros, por lo cual es considerado un agente zoonótico importante (1). Aunque M. tuberculosis es el agente etiológico más frecuente de la tuberculosis humana, ésta también puede ser producida por M...

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“…In particular, African-American migrants from the agrarian South may have had greater exposure to Mycobacterium bovis than non-migrants. As a considerably larger proportion of M. bovis than Mycobacterium tuberculosis infections result in extrapulmonary disease [26] it is possible that the trend of increasing disparty reflects, at least in part, these exposure differences. However, our reliance on pediatric TBM mortality makes this explanation less likely, as there is no evidence of persistent human-to-human M. bovis transmission [27].…”

Section: Discussionmentioning

confidence: 99%

Racial inequality in the annual risk of Tuberculosis infection in the United States, 1910–1933

2017

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SUMMARYTuberculosis (TB) mortality rates in the USA fell rapidly from 1910 to 1933. However, during this period, racial disparities in TB mortality in the nation's expanding cities grew. Because of long delays between infection and disease, TB mortality is a poor indicator of short-term changes in transmission. We estimated the annual risk of TB infection (ARTI) in 11 large US cities to understand whether rising inequality in mortality reflected rising inequality in ARTI using city-level TB mortality data compiled by the US Department of Commerce from 1910 to 1933. We estimated ARTI for African-Americans and whites using pediatric extrapulmonary TB mortality data for African-Americans and whites in our panel of cities. We also estimated age-adjusted pulmonary TB mortality rates for these cities. We find that the ratio of ARTI for African-Americans vs. whites increased from 2·1 (95% CI = 1·7, 2·4) in 1910 to 4·2 (95% CI = 3·4, 5·2) in 1933. This change mirrored the increasing inequality in age-adjusted pulmonary TB mortality during this period. These findings may reflect the combined effects of migration, inequality in access to care, increasing population density, and racial residential segregation in northern cities during this period.

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ZoonoticMycobacterium bovis–induced Tuberculosis in Humans

Cited by 340 publications

References 24 publications

Genetic diversity of Mycobacterium bovis in Jalisco, Mexico: Tracing back sources of infection

Genetic diversity of Mycobacterium bovis in Jalisco, Mexico: Tracing back sources of infection

First approach to molecular epidemiology of bovine tuberculosis in Colombia

Racial inequality in the annual risk of Tuberculosis infection in the United States, 1910–1933

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