Zoonotic Transmission of Antimicrobial-Resistant Enterococci: A Threat to Public Health or an Overemphasized Risk?

Bortolaia, Valeria; Guardabassi, Luca

doi:10.1007/978-3-030-85877-3_16-1

Cited by 1 publication

(2 citation statements)

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“…Enterococci can gain resistance to antibiotics through chromosomal mutations and horizontal gene transfer. Enterococci are naturally resistant to a wide range of antibiotic classes 15 . Thus, enterococci present a major challenge to illness treatment because of their limited susceptibility to antibiotics, which is caused by both intrinsic and acquired resistance.…”

Section: Discussionmentioning

confidence: 99%

“…The emergence of antimicrobial resistance in zoonotic bacteria poses a substantial risk to public health, mainly owing to the heightened likelihood of treatment failures. Furthermore, the emergence of resistance, particularly through the acquisition of transmissible genetic components, might also impact other characteristics, such as the capacity to inhabit an animal host or endure in agricultural or food-processing settings 14 , 15 . The presence of antibiotic-resistant enterococci in meat, animal-related sources, and habitats linked to animals, food-handling equipment, and healthy humans emphasizes the importance of evaluating enterococci in slaughterhouses as well.…”

Section: Introductionmentioning

confidence: 99%

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Species prevalence, virulence genes, and antibiotic resistance of enterococci from food-producing animals at a slaughterhouse in Turkey

Cebeci

2024

Sci Rep

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Healthy cattle, sheep, and goats can be reservoirs for gastrointestinal pathogenic fecal enterococci, some of which could be multidrug-resistant to antimicrobials. The objective of this study was to determine the prevalence and diversity of Enterococcus species in healthy sheep, goat, and cattle carcasses, as well as to analyze the antimicrobial resistance phenotype/genotype and the virulence gene content. During 2019–2020, carcass surface samples were collected from 150 ruminants in a slaughterhouse. A total of 90 enterococci, comprising five species, were obtained. The overall prevalence of enterococci was found to be 60%, out of which 37.7% were identified as Enterococcus (E.) hirae, 33.3% as E. casseliflavus, 15.5% as E. faecium, 12.2% as E. faecalis, and 1.1% as E. gallinarum. Virulence-associated genes of efaA (12.2%) were commonly observed in the Enterococcus isolates, followed by gelE (3.3%), asaI (3.3%), and ace (2.2%). High resistance to quinupristin-dalfopristin (28.8%), tetracycline (21.1%), ampicillin (20%), and rifampin (15.5%) was found in two, four, four, and five of the Enterococcus species group, respectively. The resistance of Enterococcus isolates to 11 antibiotic groups was determined and multidrug resistant (MDR) strains were found in 18.8% of Enterococcus isolates. Characteristic resistance genes were identified by PCR with an incidence of 6.6%, 2.2%, 1.1%, 1.1%, 1.1%, and 1.1% for the tetM, ermB, ermA, aac(6ʹ)Ie-aph(2")-la, VanC1, and VanC2 genes in Enterococcus isolates, respectively. Efflux pump genes causing multidrug resistance were detected in Enterococcus isolates (34.4%). The results showed that there were enterococci in the slaughterhouse with a number of genes linked to virulence that could be harmful to human health.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%