Zosteriform bullous eruption in a patient with antineutrophil cytoplasmic antibody‐negative eosinophilic granulomatosis with polyangiitis

Ng, Woon Chai; Chen, Yu‐Chia; Su, Yung-Ling

doi:10.1111/ijd.14670

Cited by 1 publication

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“…A variety of cutaneous manifestations have been described, 3,4 but nonvasculitic bullous eruptions are rare. Of interest, most of the reported EGPA cases with bullous eruptions were ANCA negative, 5–7 except one case with positive ANCA 8 . It was postulated that ANCA‐positive EGPA is characterized by a primarily vasculitic pattern, whereas ANCA‐negative EGPA predominantly presents with tissue eosinophilia and the resultant tissue deposition of extracellular eosinophilic cytotoxic granular proteins 9 .…”

Section: Discussionmentioning

confidence: 99%

Bullous eruption as a cutaneous manifestation of eosinophilic granulomatosis with polyangiitis

Tjokrosaputro

Lian

Wang

et al. 2021

Rheumatology & Autoimmunity

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Cutaneous manifestations are variable in patients with eosinophilic granulomatosis with polyangiitis (EGPA). We report a case where bullous eruption was a presenting manifestation of EGPA. A 55‐year‐old Chinese man with a background of adult‐onset asthma and chronic sinusitis was admitted for a 3‐week history of lower limb weakness and a large bulla on his right calf with surrounding erythema. Skin biopsy showed a subepidermal blister with significant dermal eosinophilia, without vasculitis. The patient was diagnosed with EGPA with systemic involvement on the basis of a thorough medical history, eosinophilia, cardiac magnetic resonance imaging showing acute myocarditis, and nerve biopsy with eosinophilic vasculitic neuropathy. He responded well to corticosteroids and rituximab. Nonvasculitic bullous eruptions are rarely described as manifestations of EGPA. Prompt recognition of this entity is crucial for its early diagnosis.

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