Zotarolimus compared with everolimus eluting stents‐angiographic and clinical results after recanalization of true coronary chronic total occlusions

Markovic, Sinisa; Lützner, Michael; Rottbauer, Wolfgang; Wöhrle, Jochen

doi:10.1002/ccd.26482

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Over 80% of the patients in our study underwent angiographic follow‐up (8.7 ± 3.9 months after the index procedure) and binary restenosis was observed in 12 of 64 lesions (18.8%). This finding may be promising, given that CTO lesions treated with the current generation of DES have shown restenosis rates of 15%–20% 1–3 . When lesions with restenosis were compared to those without restenosis, a statistically significant difference was found in the occlusion length ( p = 0.016) but not in the lesion length ( p = 0.13).…”

Section: Discussionmentioning

confidence: 81%

“…This finding may be promising, given that CTO lesions treated with the current generation of DES have shown restenosis rates of 15%-20%. [1][2][3] When lesions with restenosis were compared to those without restenosis, a statistically significant difference was found in the occlusion length (p = 0.016) but not in the lesion length (p = 0.13).…”

Section: Discussionmentioning

confidence: 92%

“…The incidence of in-stent restenosis in CTO lesions is reported to be 15%-20% even with the new-generation DES, which is considerably higher than in non-CTO lesions. [1][2][3] In addition, late stent thrombosis in CTO lesions is more frequent than in non-CTO lesions 4 because of slower endothelial coverage of the stent struts and a higher incidence of late-acquired stent malapposition. 5,6 Therefore, patients who undergo CTO-PCI with DES must endure prolonged dual antiplatelet therapy (DAPT).…”

Section: Introductionmentioning

confidence: 99%

“…However, primary implantation of drug‐eluting stents (DES), which is the current therapy of choice, still carries inherent risks. The incidence of in‐stent restenosis in CTO lesions is reported to be 15%–20% even with the new‐generation DES, which is considerably higher than in non‐CTO lesions 1–3 . In addition, late stent thrombosis in CTO lesions is more frequent than in non‐CTO lesions 4 because of slower endothelial coverage of the stent struts and a higher incidence of late‐acquired stent malapposition 5,6 .…”

Section: Introductionmentioning

confidence: 99%

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Intraplaque wiring enables drug‐coated balloons to be utilized for percutaneous recanalization of chronically occluded coronary arteries

Terashita

Shimada

Yamanaka

et al. 2023

Cathet Cardio Intervent

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Objectives This study aimed to determine whether drug‐coated balloon (DCB) angioplasty following intraplaque wiring and the use of modified balloons is safe and effective in the percutaneous treatment of coronary chronic total occlusions (CTOs). Background DCB is an alternative therapeutic option without the limitations of permanent vascular implants. However, its efficacy in CTOs has yet to be confirmed. The combination of modified balloons and DCB can be effectively applied when the intraplaque passage of the guidewire is achieved in CTOs. Methods Data from 124 consecutive CTO lesions (105 patients) treated at our hospital between February 2016 and December 2020 were screened for inclusion and retrospectively analyzed. Among the 118 lesions successfully recanalized, intraplaque wiring was achieved in 108, and 85 were treated by the DCB‐only approach following cutting/scoring balloon dilatation. Results Follow‐up data were available for 82 lesions (71 patients). The median occlusion length was 18.5 mm, and the J‐CTO score was 1.7 ± 0.9. No in‐hospital major adverse cardiac events occurred, including abrupt vessel closure. During the median 29‐month follow‐up period, target lesion revascularization was performed for 10 lesions. Follow‐up coronary angiography (8.7 ± 3.9 months after the index procedure) was performed for 64 lesions, demonstrating late lumen loss of −0.15 mm (interquartile range −0.4 to 0.23 mm), binary restenosis (diameter stenosis ≥50%) in 12 lesions (18.8%), and late lumen enlargement in 37 (57.8%). Conclusion The DCB‐only approach following the use of modified balloons is a promising strategy for coronary CTOs when intraplaque wiring is achieved.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 92%