“…Despite all concerns, there is no scientific consensus on whether the short-or long-term nickel concentration increases are significant after placing the orthodontic appliances [9][10][11]36,[42][43][44][45][46][47][48][55][56][57][58] and the real impact in human health [2,15,32,59]. Allergies in orthodontics are (fortunately) rare [31,60], but may be ineffectively diagnosed: subtle signs can be misinterpreted as mechanical injuries or bacterial-related [2,54,61,62]. Furthermore, while some researchers reported that salivary nickel leaching significantly increased after starting the orthodontic treatment [9,10,40,41,[44][45][46][47]49,58], others found no significant oral concentration changes [11,36,48,55,56].…”