Zur Bedeutung chemisch-biologischer Wechselwirkungen f�r die toxische und krebserzeugende Wirkung aromatischer Amine

Metzler, Manfred; Hg, Neumann

doi:10.1007/bf00304284

Cited by 22 publications

(1 citation statement)

References 25 publications

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“…34−39 The development of analytical methods to measure protein toxicant/carcinogen adducts in humans advanced by the late 1970s and 1980s, when laboratories employed adducts to hemoglobin (Hb) and Alb to assess carcinogen exposure. 37,40−43 Since these hallmark studies, the mechanisms of enzymatic bioactivation of chemicals and the analytical methods used to measure protein toxicant adduct formation have evolved and are routinely applied to the preclinical safety assessment of drugs. Alb is used as a target protein to prescreen potentially toxic drug-candidates.…”

Section: Introduction To Human Biomonitoring and History Of Protein Amentioning

confidence: 99%

Biomonitoring Human Albumin Adducts: The Past, the Present, and the Future

Sabbioni¹,

Turesky

2016

Chem. Res. Toxicol.

105

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Serum albumin (Alb) is the most abundant protein in blood plasma. Alb reacts with many carcinogens and/or their electrophilic metabolites. Studies conducted over 20 years ago showed that Alb forms adducts with the human carcinogens aflatoxin B1 and benzene, which were successfully used as biomarkers in molecular epidemiology studies designed to address the role of these chemicals in cancer risk. Alb forms adducts with many therapeutic drugs or their reactive metabolites such as β-lactam antibiotics, acetylsalicylic acid, acetaminophen, nonsteroidal anti-inflammatory drugs, chemotherapeutic agents, and antiretroviral therapy drugs. The identification and characterization of the adduct structures formed with Alb have served to understand the generation of reactive metabolites and to predict idiosyncratic drug reactions and toxicities. The reaction of candidate drugs with Alb is now exploited as part of the battery of screening tools to assess the potential toxicities of drugs. The use of gas chromatography-mass spectrometry, liquid chromatography, or liquid chromatography-mass spectrometry (LC-MS) enabled the identification and quantification of multiple types of Alb xenobiotic adducts in animals and humans during the past three decades. In this perspective, we highlight the history of Alb as a target protein for adduction to environmental and dietary genotoxicants, pesticides, and herbicides, common classes of medicinal drugs, and endogenous electrophiles, and the emerging analytical mass spectrometry technologies to identify Alb-toxicant adducts in humans.

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Section: Introduction To Human Biomonitoring and History Of Protein Amentioning

confidence: 99%

Biomonitoring Human Albumin Adducts: The Past, the Present, and the Future

Sabbioni¹,

Turesky

2016

Chem. Res. Toxicol.

105

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Monozyklische aromatische Amino‐ und Nitroverbindungen [MAK Value Documentation in German language, 2003]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 37. Lieferung, Ausgabe 2003 Der Artikel enthält folgende Kapitel: Einleitung Einstufung Toxizität Hinweise auf nicht‐genotoxische Effekte Genotoxizität In vitro In vivo Tumorentstehung Wirksamkeit Diskussion Wirkungsmechanismus Struktur‐Wirkungs‐Beziehungen Der Einfluss der Stellungsisomerie Analogien zwischen Arylaminen und Nitroverbindungen Die Gemeinsamkeiten Die Unterschiede Folgerungen für die Einstufung Schlussfolgerungen Ausblick

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Monocyclic aromatic amino and nitro compounds [MAK Value Documentation, 2005]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series MAK Value Documentations , Vol. 21 (2005) The article contains sections titled: Introduction Classification Toxicity Evidence of non‐genotoxic effects Genotoxicity In vitro In vivo Tumour formation Potency Discussion Mechanism of Action Structure‐effect relationships The effect of position isomerism Analogy between arylamines and nitro compounds Similarities The differences Conclusions for the classification Conclusions Prospects

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Zur Bedeutung chemisch-biologischer Wechselwirkungen f�r die toxische und krebserzeugende Wirkung aromatischer Amine

Cited by 22 publications

References 25 publications

Biomonitoring Human Albumin Adducts: The Past, the Present, and the Future

Biomonitoring Human Albumin Adducts: The Past, the Present, and the Future

Monozyklische aromatische Amino‐ und Nitroverbindungen [MAK Value Documentation in German language, 2003]

Monocyclic aromatic amino and nitro compounds [MAK Value Documentation, 2005]

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