Zur Beteiligung der Leber bei der infektiösen Mononucleose

Enzyme Activities in Human Liver

“…In 13 patients we found the following qualitative differences to viral hepatitis : an increase of GOT and GLDH, a decrease of enolase and PK and no significant alterations of GPT and ICDH. The other deviations from normal in hepatitis mononucleosa correspond to those of milder types of viral hepatitis [99]. During recovery from infectious mononucleosis, there is not only a return of enzyme activities to normal, but strangely enough, a shift back past normal, particularly of the transaminases and of ADH.…”

Biochemical studies on hepatic involvement in infectious mononucleosis

“…Gelb, West, and Zimmerman (1962) found a higher incidence of raised serum globulin (but equivalent abnormal flocculations) and of serum alkaline phosphatase, and less increase of serum isocitric dehydrogenase. The high serum lactic dehydrogenase found by them and by Kalk et al (1960) is thought to originate in the affected lymphatic system. The differences between these series can be largely explained on different relative severities of illness, and possibly on methodological criteria.…”

“…Frequent hepatic involvement in infectious mononucleosis has been shown by liver biopsy (Nelson and Darragh, 1956;Sullivan, Irey, Pileggi, Crone, and Gibson, 1957), conventional liver function tests (Wechsler, Rosenblum, and Sills, 1946;Schultz and Hall, 1952;Mason and Adams, 1958), and serum transaminases (Sullivan et al, 1957;Rosalki, Jones, and Verney, 1960) and other enzymes (Kalk, Schmidt, Schmidt, and Wildhirt, 1960). We consider that the abnormal enzyme findings in infectious mononucleosis are due to almost universal hepatocellular damage; neither serum I.C.D.…”