Zur Biochemie der Knochenauflösung, II. Der Einfluß von Diamox auf das Plasma-Calcium östron-behandelter Hähne

Dulce, Hans-Joachim; Siegmund, Peter

doi:10.1515/bchm2.1960.320.1.160

Cited by 11 publications

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“…Siegmund and his associates (6)(7)(8)(9)(10) were the first to suggest that the enzyme carbonic anhydrase, which is capable of catalyzing the hydration of CO 2 to carbonic acid, plays an important role in PTH-induced bone resorption. This work has been unaccountably ignored, perhaps because it was done in an avian species, the chicken.…”

Section: Discussionmentioning

confidence: 99%

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Inhibition of Bone Resorption by Acetazolamide in the Rat¹

1970

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The carbonic anhydrase inhibitor, acetazolamide, has been found to elicit a hypocalcemic response in acutely nephrectomized rats. This effect cannot be attributed to changes in pCCh, pH citrate, phosphate or protein. Administration of acetazolamide to parathyroidectomized-nephrectomized rats has been shown to inhibit the hypercalcemic response to parathyroid extract and dibutyryl cyclic 3',5'-AMP. The hypercalcemic response to epinephrine was not inhibited in the same preparation. These data are consistent with the hypothesis that cyclic 3',5'-AMP is the second messenger of parathyroid hormone in its action on bone, and that carbonic acid production may be a later, or possibly the final, messenger of the hormone.

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Section: Discussionmentioning

confidence: 99%

“…Whereas Siegmund and his associates (6)(7)(8)(9)(10) have concluded that the enzyme is important in PTH-induced bone resorption in the chicken, the role of carbonic anhydrase in mammalian bone metabolism is more controversial. Two reports have failed to implicate the enzyme (11,12).…”

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confidence: 99%