Zur Differenzierung der Wirkung verschiedener Veratrum-Alkaloide auf die Lungendehnungsreceptoren und auf die Atemt�tigkeit

Zipf, H. F.; Marquardt, Hans; Ahad, Abdul

doi:10.1007/bf00536225

Cited by 3 publications

(3 citation statements)

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“…These investigations were complemented by recordings of the activity of single fibres from pulmonary stretch receptors, which showed after veratridine injection an increased frequency in the inspiratory volleys, and tonic, frequency modulated activity, coupled with slowing of breathing. This has been confirmed for rabbits [Meier, Bein and Helmich, 1949], cats [Paintal, 1953] and guinea pigs [Zipf and Marquardt, 1966]. Thus the vagal pathway for the inhibitory effects of veratrum alkaloids on breathing is well established [see also Herzog, 1958; Hapke, 1963a and b].…”

mentioning

confidence: 56%

The Effect of Intravascular Injections of Veratrine on Laryngeal Resistance to Airflow in Cats

Szereda‐Przestaszewska¹,

Widdicombe²

1973

Exp Physiol

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Changes in laryngeal resistance to airflow have been measured in cats during spontaneous breathing through the larynx, and while the larynx was isolated in 8itU with constant airflow. Intravenous injections of veratrine resulted in apnoea with a large increase in laryngeal resistance, followed by expiratory increases in laryngeal resistance. These responses were abolished by cutting the vagi in the chest and were absent on injection of veratrine into the left atrium, which established the pulmonary nerves as the main afferent pathway for the reflex. It is concluded that stimulation of pulmonary receptors constricts the larynx.Many papers deal with the veratrum alkaloids and their influence on the cardiovascular and respiratory systems [Dawes and Comroe, 1954] and the hypotension, bradycardia and arrest of breathing induced by intravenous injections of veratrum alkaloids, classically described by Bezold and Hirt [1867], are known to depend on vagal reflexes. The inhibition of respiration caused by veratrine -a mixture of veratrum alkaloids -was studied by Dawes, Mott and Widdicombe [1951] who showed that the apnoea observed in cats with small doses of veratridine (a pure alkaloid) is blocked by cooling the vagi to 10TC, and that the lung receptors responsible for this response are the pulmonary stretch endings. These investigations were complemented by recordings of the activity of single fibres from pulmonary stretch receptors, which showed after veratridine injection an increased frequency in the inspiratory volleys, and tonic, frequency modulated activity, coupled with slowing of breathing. This has been confirmed for rabbits [Meier, Bein and Helmich, 1949], cats [Paintal, 1953] and guinea pigs [Zipf and Marquardt, 1966]. Thus the vagal pathway for the inhibitory effects of veratrum alkaloids on breathing is well established [see also Herzog, 1958; Hapke, 1963a and b].The reflex cardiovascular actions of injections of veratrine are mediated mainly by stimulation of receptors in the muscle of the ventricles of the heart, probably with nonmyelinated vagal fibres [Sleight and Widdicombe, 1965].In previous experiments we have found increases in laryngeal resistance in expiration with induction of respiratory reflexes from the lungs and the upper airways [Stransky, Widdicombe, 1972, 1973] and have here tried to relate the respiratory changes induced by veratrine to quantitative measurements of laryngeal resistance to airflow.

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mentioning

confidence: 56%

The Effect of Intravascular Injections of Veratrine on Laryngeal Resistance to Airflow in Cats

Szereda‐Przestaszewska¹,

Widdicombe²

1973

Exp Physiol

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“…With doses of the Veratrum ester alkaloids of the order required for hypotensive therapeutic action, respiratory effects usually are inconspicuous, except for a tachypnea with inspiratory emphasis which has been observed under experimental conditions (MOE et aI., 1944;ZIPF and MARQUARDT, 1966). Higher doses cause respiratory depression and apnea; e.g., in the guinea pig, doses of 1 to 15 [log/kg protoveratrine A led to tachypnea while apnea occurred at the dosage level of 20 [log/kg or above (ZIPF and MARQUARDT, 1966).…”

Section: B Respirationmentioning

confidence: 95%

“…Higher doses cause respiratory depression and apnea; e.g., in the guinea pig, doses of 1 to 15 [log/kg protoveratrine A led to tachypnea while apnea occurred at the dosage level of 20 [log/kg or above (ZIPF and MARQUARDT, 1966).…”

Section: B Respirationmentioning

confidence: 98%