Zur Epidemiologie der Varizella-Zoster-Infektion

Paul, Eberhard; Thiel, Tillmann

doi:10.1007/s001050050476

Cited by 37 publications

(17 citation statements)

References 10 publications

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“…It is estimated that, in Europe, approximately 12,000 hospitalizations each year are due to HZ and its complications [38,48,54-56]. HZ complications which are likely to lead to hospitalization are PHN, encephalitis or meningitis and ocular complications [57].…”

Section: Discussionmentioning

confidence: 99%

The impact of herpes zoster and post-herpetic neuralgia on quality-of-life

Johnson¹,

Bouhassira

Kassianos

et al. 2010

BMC Med

321

257

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BackgroundThe potentially serious nature of herpes zoster (HZ) and the long-term complication post-herpetic neuralgia (PHN) are often underestimated. One in four people will contract herpes zoster in their lifetime, with this risk rising markedly after the age of 50 years, and affecting one in two in elderly individuals. Pain is the predominant symptom in all phases of HZ disease, being reported by up to 90% of patients. In the acute phase, pain is usually moderate or severe, with patients ranking HZ pain as more intense than post-surgical or labour pains. Up to 20% of patients with HZ develop PHN, which is moderate-to-severe chronic pain persisting for months or years after the acute phase. We review the available data on the effect of HZ and PHN on patients' quality-of-life.DiscussionFindings show that HZ, and particularly PHN, have a major impact on patients' lives across all four health domains - physical, psychological, functional and social. There is a clear correlation between increasing severity of pain and greater interference with daily activities. Non-pain complications such as HZ ophthalmicus can increase the risk of permanent physical impairment. Some elderly individuals may experience a permanent loss of independence after an acute episode of HZ. Current challenges in the management of HZ and PHN are highlighted, including the difficulty in administering antiviral agents before pain becomes established and the limited efficacy of pain treatments in many patients. We discuss the clinical rationale for the HZ vaccine and evidence demonstrating that the vaccine reduces the burden of the disease. The Shingles Prevention Study, conducted among >38,000 people aged ≥60 years old, showed that the HZ vaccine significantly reduces the burden of illness and the incidence of both HZ and PHN. In the entire study population, zoster vaccination reduced the severity of interference of HZ and PHN with activities of daily living by two-thirds, as measured by two questionnaires specific to HZ.SummaryA vaccination scheme may positively impact the incidence and course of HZ disease, thereby improving patients' quality-of-life.

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Section: Discussionmentioning

confidence: 99%

The impact of herpes zoster and post-herpetic neuralgia on quality-of-life

Johnson¹,

Bouhassira

Kassianos

et al. 2010

BMC Med

321

257

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“…Mit zunehmendem Alter steigt die Erkrankungsrate jedoch erheblich an [21,22]. Nach einer der größten amerikanischen Studien liegt die Inzidenz des Zoster im höheren Erwachsenenalter (>50-Jährige) mit 10,1 Fällen pro 1000/Jahr um etwa das 8fache höher als die Inzidenz des Zoster im Jugendalter (10-bis 19-Jährige) mit 1,38 Fällen pro 1000/Jahr [9].…”

Section: Schlüsselwörterunclassified

Bilateraler asymmetrischer Zoster im Jugendalter

Bloss¹,

Ebisch²,

Kunz³

et al. 2001

Der Hautarzt

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Zoster is a frequent disease of adulthood with a distinct age-dependent increase after 60. In contrast during childhood or adolescence zoster only rarely occurs. Certain risk factors such as hematologic malignancies are associated with early appearance. The typical clinical manifestation is unilateral, equally involving thoracic dermatomes. A 16-year-old patient presented with zoster in bilateral asymmetrical distribution, with trigeminal and thoracic dermatomes simultaneously affected. Despite the clinical findings and the unusual localization, there was no history, clinical nor laboratory signs of an immune suppression or any other underlying disease. Careful follow-up examinations are necessary in order to recognize systemic, especially hematologic, malignancies.

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“…In Western countries, the estimated incidence of acute HZ in the general population is 3–5 per 1,000 person-years (annual events per 1,000 population)(Gauthier et al 2009; Hope-Simpson 1965; Paul and Thiel 1996; di Luzio Paparatti et al 1999; Chidiac et al 2001; Brisson and Edmunds 2003; de Melker et al 2006; Yawn et al 2007). HZ incidence increases with age because of a decline in specific immunity against latent VZV (Arvin 2005).…”

Section: Introductionmentioning

confidence: 99%

“…HZ incidence increases with age because of a decline in specific immunity against latent VZV (Arvin 2005). There is a marked increase in annual risk starting at approximately 50 years of age that may reach >10 per 1,000 person-years in those aged ≥80 years (Gauthier et al 2009; Hope-Simpson 1965; Paul and Thiel 1996; de Melker et al 2006; Yawn et al 2007). One in four people will contract HZ in their lifetime, with this risk rising to one in two individuals ≥85 years old (Schmader 2001; Miller et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Impact of herpes zoster and post-herpetic neuralgia on patients’ quality of life: a patient-reported outcomes survey

et al. 2010

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BackgroundThe impact of herpes zoster (HZ) and post-herpetic neuralgia (PHN) on patients’ quality of life (QoL) is currently poorly documented.Subjects and methodsTelephone interviews in Germany identified patients ≥50 years old with painful HZ diagnosed during the previous 5 years. Bespoke questions evaluated previous HZ episodes.ResultsOf 11,009 respondents, 280 met the screening criteria, and 32 (11%) developed PHN. PHN was associated with significantly worse outcomes than HZ (all P < 0.05). Mean pain scores associated with PHN and HZ, respectively, were 7.1 and 6.2 (average) and 8.2 and 7.0 (worst). Many patients with PHN (91%) and HZ (73%) experienced problems with daily activities, including work, studies, housework, family and leisure activities. Mean pain interference scores in patients with PHN versus HZ were highest for sleep (6.5 versus 4.9), normal work (6.1 versus 4.4) and mood (5.9 versus 4.4). Most employed interviewees with PHN (70%) and HZ (64%) stopped work during the disease. Pain and QoL outcomes were not significantly different between all patients versus those diagnosed during the previous 12 months or between patients aged 50–59 years versus ≥60 years.ConclusionsHZ causes substantial pain, which seriously interferes with many aspects of daily life, particularly in patients with PHN.

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Zur Epidemiologie der Varizella-Zoster-Infektion

Cited by 37 publications

References 10 publications

The impact of herpes zoster and post-herpetic neuralgia on quality-of-life

The impact of herpes zoster and post-herpetic neuralgia on quality-of-life

Bilateraler asymmetrischer Zoster im Jugendalter

Impact of herpes zoster and post-herpetic neuralgia on patients’ quality of life: a patient-reported outcomes survey

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