Zur Frage der Blutdrucksteigerung

Volhard, Franz; Hülse, Walter

doi:10.1007/bf02622972

Cited by 7 publications

(3 citation statements)

References 3 publications

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“…The arteriolar degenerative lesions varied in nature and severity 4 (see Figs. [1][2][3][4][5]. In some of the arterioles, there was some hyalin immediately beneath the endothelial lining of the intima which remained intact ( Fig.…”

Section: Microscopic Examination Of the Tissuesmentioning

confidence: 99%

Studies on Experimental Hypertension

Goldblatt

1938

Journal of Experimental Medicine

148

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The production of the acute malignant phase of experimental hypertension has been accomplished in seventeen dogs. The method used to produce this type of hypertension was the same as for the benign type (4), namely, constriction of the main renal arteries, or the equivalent, constriction of the aorta above the origin of both main renal arteries, but the constriction was especially severe. The malignant phase in the animals was characterized by hypertension, terminal renal insufficiency and the development of petechiae and larger hemorrhages in many internal organs, especially the alimentary tract. These were due to dissecting hemorrhage through, or rupture of, the wall of severely hyalinized or necrotic arterioles, or rupture of capillaries. Hyalinization and necrosis of arterioles were more severe and more widespread in animals that had a period of benign hypertension before the onset of renal insufficiency. In animals with a previous long period of benign hypertension, thickening of the media also occurred in arterioles, with or without hyalinized intima. Elevation of blood pressure (mechanical factor) and renal insufficiency (humoral factor) are at least two of the necessary conditions for the development of the necrotic arterioles and hemorrhages. Necrotic arterioles and hemorrhages have not yet been observed in animals that have had very high blood pressure for years without renal insufficiency, nor in animals with azotemia, due to removal of both kidneys, but without hypertension. Hyalinized retinal arterioles have been observed in dogs with persistent hypertension and with moderate or no disturbance of renal function. That ischemia is not the cause of the necrosis of the arterioles is shown by their absence from the ischemic kidneys of the dogs and their widespread presence in other organs that were not ischemic. These experiments show that the necrotic arterioles and hemorrhages are secondary to and not the primary cause of the malignant phase of hypertension.

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Section: Microscopic Examination Of the Tissuesmentioning

confidence: 99%

Studies on Experimental Hypertension

Goldblatt

1938

Journal of Experimental Medicine

148

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“…Subsequent to the work of Volhard [3] and Ellis [24], clinical common sense readily agreed with the postulate that renal failure progressed more rapidly in the presence of hypertension. However, little documentation for this notion is available.…”

Section: Epidemiology Of Hypertension In Glomerulonephritismentioning

confidence: 66%

“…As a result, the mean pressure of the arterial system must increase. ' Finally, Franz Volhard [3] introduced the concept of the 'vicious circle' implying that renal disease causes hypertension which in turn adversely affects renal out come. 'Thus hypertension is of overriding importance for the most sinister characteristics of renal disease, i.e.…”

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confidence: 99%