Zur Frage der sogenannten Encephalitis congenita (Virchow) I. Teil. Über normale und pathologische Fettkörnchenzellbeiunde bei Neugeborenen und Säuglingen

Wohlwill, Friedrich

doi:10.1007/bf02892239

Cited by 24 publications

(5 citation statements)

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“…Within each focus there were not only typical oligodendrocytes and astrocytes bLt also cells with central variably staining nuclei surrounded by vacuolated cytoplasm that stained red with oil red 0. These cells probably correspond to the type 1 cell of Wohlwill [34] and therefore must be regarded as participants in normal myelinogenesis, not as reactants to tissue necrosis as suggested by Sumi 1271. In the experimental animals, necrosis commencing in these foci spreads widely within the collosal radiation and internal capsule.…”

Section: Discussionmentioning

confidence: 94%

The influence of immaturity on hypoxic‐ischemic brain damage in the rat

Rice

Vannucci

Brierley

1981

Annals of Neurology

1,983

1,508

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Brain damage in the Levine preparation (unilateral common carotid artery ligation with hypoxia) consists of ischemic neuronal alterations in the ipsilateral forebrain. As the model has been restricted to adult animals, unilateral common carotid artery ligation was carried out in 7-day-postnatal rats. Four to 8 hours later the 25 pups were exposed to 8% oxygen at 37 degrees C for 3.5 hours. Controls consisted of littermates subjected to carotid ligation without subsequent hypoxia, hypoxia without prior ligation, and neither ligation nor hypoxia. After hypoxia the animals were returned to their dams and appeared normal for up to 50 hours. All pups were then killed by perfusion-fixation. Moderate to severe ischemic neuronal changes were seen in the ipsilateral cerebral cortex, striatum, and hippocampus in at least 90% of the animals and included infarction in 56% of the brains. Cortical damage was occasionally laminar but more often occurred in columns at right angles to the pial surface. Unlike adult animals, there was necrosis of white matter, greater ipsilaterally, originating in and spreading from myelinogenic foci. The evolution of ischemic cell change and the associated gliomesodermal reaction was more rapid than in the adult. In 22 additional pups subjected to carotid artery ligation and hypoxia, brains were analyzed for water content. Significant increases (0.6 to 3.3%) in water content of the ipsilateral hemispheres occurred in 11 of 22 brains (50%). Unilateral ischemia combined with hypoxia in developing rats therefore results in neuronal destruction in the same brain regions as in adult animals, but also causes necrosis of white matter. The incidence of increased water content was similar to that of overt infarction. Thus, as previously shown in the adult, brain edema is a consequence rather than a cause of major ischemic damage in the immature animal.

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Section: Discussionmentioning

confidence: 94%

The influence of immaturity on hypoxic‐ischemic brain damage in the rat

Rice

Vannucci

Brierley

1981

Annals of Neurology

1,983

1,508

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“…All three cases showed an abnormal accumulation of sudanophilic lipid which is not a feature of older children with spongy disease. A variable but small amount of lipid is present in the cerebral white matter of all babies dying in the neonatal period; the cells which carry the fat do not have the appearance of microglia but are thought to be astrocytes and oligodendrocytes (Wohlwill, 1921;Rydberg, 1932). The fat-containing cells are always found in the same distribution in the newborn baby's brain, being plentiful in the corpus callosum and centrum semiovale and absent from the subcortical white matter.…”

Section: Discussionmentioning

confidence: 99%

Spongy degeneration in the white matter of the central nervous system in the newborn: pathological findings in three infants, one with hyperglycinaemia.

Anderson¹

1969

Journal of Neurology, Neurosurgery & Psychiatry

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“…Sudanophilic lipid droplets in glial cells in the unmyelinated cerebral white matter of human infants have been viewed by some to be the result of perinatal hypoxia (14,18,19) whereas others have regarded them as normal precursors of cerebral myelination (17,26). The discovery of similar lipid accumulations in the brains of infant subhuman primates, made hypoxic and acidotic by manipulating the maternal blood pressure (22,23), and in foci of spontaneous periventricular leukomalacia (21), appeared to support the first interpretation.…”

Section: Discussionmentioning

confidence: 99%

“…Some investigators ( 14,18,19) have considered these cells to be pathologic, the result of hypoxia or other stresses in the perinatal period, and termed "glial fatty metamorphosis" (14). Others (17,26) regard them as nonpathologic, but the normal precursors of myelination.…”

mentioning

confidence: 99%

Maternal Corticosteroid Therapy and the Fetal Brain in Experimental Hyaline Membrane Disease

1984

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Summaryrespiratory function of each fetus was determined and supported. The animals were sacrificed at 3 h of age. The possible acute deleterious effects of maternal glucocortiBrain weights were similar in the two groups. Dark, shrunken, coid administration on the fetal nervous system and the patho-pyknotic neurons were present in the hippocampus of three logic significance of sudanophilic lipids in glial cells were studied treated and two control animals. Lipid-containing glial cells were in the premature pigtail monkey (macaca mulatta). At 72, 48, present in all animals. Neither appeared to be related to steroid and 24 h before delivery at 135 f 1 d gestation, dams were treatment or to the degree of respiratory distress. treated with either 4 mg dexamethasone or saline. After delivery,We conclude that short-term glucocorticoid therapy in doses

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Zur Frage der sogenannten Encephalitis congenita (Virchow) I. Teil. Über normale und pathologische Fettkörnchenzellbeiunde bei Neugeborenen und Säuglingen

Cited by 24 publications

References 0 publications

The influence of immaturity on hypoxic‐ischemic brain damage in the rat

The influence of immaturity on hypoxic‐ischemic brain damage in the rat

Spongy degeneration in the white matter of the central nervous system in the newborn: pathological findings in three infants, one with hyperglycinaemia.

Maternal Corticosteroid Therapy and the Fetal Brain in Experimental Hyaline Membrane Disease

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