Zur Frage der zentralen �bertragung afferenter Impulse

Estimation of Substance P in Mouse Brain. The Identification of Interfering Nucleotides in the Extract

“…The large scatter of the results of assay of substance P in mouse brain extracts suggested the presence of a second substance influencing the assay. Similar variations in the amount of substance P in the central nervous system of different species can be found in the literature (Kopera & Lazarini, 1953;Amin et al, 1954;Zetler & Schlosser, 1955;Pernow, 1955;Paasonen & Vogt, 1956), and several workers have suggested that extracts contain a substance which inhibits contractions of smooth muscle (Euler & Gaddum, 1931;Vogt, 1949 ;Douglas, Feldberg, Paton & Schachter, 1951;Florey, 1953). Euler & Gaddum (1931), Vogt (1953) and Amin et al (1954) considered the possibility of it being an adenosine compound.…”

The distribution of substance P and 5‐hydroxytryptamine in the central nervous system of the dog

“…This difference may depend on the fact that Pernow's dogs were electrocuted and ours were anaesthetized, but on the other hand, some of the differences probably depend on differences of dissection. Kopera & Lazarini (1953) found no substance P in the cerebellum itself, but large amounts in the 'crus cerebello-cerebr'. The inclusion of some of this tissue in extracts of cerebellum would therefore greatly increase the result.…”

“…While this work has been in progress data have been published by others showing the distribution of substance P in the brains of dogs (Pernow, 1953), cows (Kopera & Lazarini, 1953;Zetler & Schlosser, 1953), and man (Zetler & Schlosser, 1954). It has already been pointed out that these results may perhaps be subject to errors.owing to the presence of HT and adenosine compounds in some of the extracts, but there is no evidence that these errors are significant and the results can be compared with one another.…”

Pharmacologically Active Substances of Mammalian Origin

“…(c) Substance P in the central nervous system : The pharmacological properties of substance P and its p revalent distribution in brain areas which contain relatively low concentrations of choline acetylase led Kopera & Lazarini (132) to the view that substance P is a noncholinergic trans mitter in the central nervous system. A similar opinion is shared by Zetler (223) who considers the polypeptide as an inhibitory transmitter, and by Stern & Milin (192 ), who consider it a "physiological tranquillizer," dis playing its depressive action mainly on the hypothalamus.…”