Zur Genealogie E. B. Christoffels

Jansen, Manfred

doi:10.1007/978-3-0348-5452-8_2

Cited by 6 publications

(6 citation statements)

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“…Providing automated assistance during the search process is another approach to helping average users. Jansen's (2004) study indicated that though only 50% subjects preferred to use the automated assistance embedded in the system, over 80% of those subjects implemented that assistance. This indicated that to some extent the automated assistance was helpful for the users.…”

Section: Related Studiessupporting

confidence: 91%

Trained vs. untrained searchers' interaction with search features in digital libraries: A case study

Zhang

Liu

et al. 2006

Proc of Assoc for Info

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Section: Related Studiessupporting

confidence: 91%

Trained vs. untrained searchers' interaction with search features in digital libraries: A case study

Zhang

Liu

et al. 2006

Proc of Assoc for Info

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“…Retrovirus vectors are the most widely used gene transfer agents in gene therapy clinical trials (27). In this study, retrovirus-mediated antisense bcl-2 RNA was used as antisense agent, which was different from previous reports about antisense bcl-2 gene therapy using bcl-2 antisense oligonucleotides as the agents (15,16,28). We found that the virus vector can effectively mediate the antisense bcl-2 gene transfer and stable expression in MGC803 cells.…”

Section: Discussionmentioning

confidence: 74%

“…For instance, the transfer and expression of bcl-2 in Chinese hamster ovary cells that were bcl-2 negative by western blotting conferred resistance to PDT (5). Meanwhile, antisense-mediated reductions in bcl-2 protein levels were shown to sensitize malignant cells to traditional chemotherapeutic agents (15,16). In view of the special relationship among bcl-2, PDT and ROS, we hypothesized that bcl-2 might be critical for inhibiting apoptosis in cancer cells treated by PDT and that reducing the amount of endogenous bcl-2 product may allow cells much more sensitive to apoptosis to be induced by PDT.…”

Section: Introductionmentioning

confidence: 99%

Antisense Bcl-2 Retrovirus Vector Increases the Sensitivity of a Human Gastric Adenocarcinoma Cell Line to Photodynamic Therapy

Zhang

Wang

et al. 1999

Photchem. Photbio.

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The bcl-2 oncoprotein directly prolongs cellular survival by blocking apoptosis and its overexpression is associated with cellular resistance to killing by chemotherapeutic drugs and gamma-irradiation. Meanwhile, it has been shown that bcl-2 antisense oligonucleotide can induce apoptosis or increase toxicity of the treatment in tumors in vivo and in vitro. However, it is difficult to obtain stable transfection by this approach and there are no reports about the effect of an antisense bcl-2 on the sensitivity to oxidative stress induced by photodynamic therapy (PDT). Here we investigated the effect of an antisense bcl-2 RNA retrovirus vector transfer on the sensitivity of 2-butylamino-2-demethoxy-hypocrellin A (2-BA-2-DMHA) photosensitization in a human gastric adenocarcinoma MGC803 cell line. The results indicate that antisense bcl-2-infected MGC803 cells expressed exogenous antisense bcl-2 mRNA measured by reverse transcription polymerase chain reaction and significantly reduced bcl-2 protein determined by western blotting analysis. The decreased expression of bcl-2 protein was accompanied by increased phototoxicity and susceptibility to apoptosis induced by 2-BA-2-DMHA PDT. Our finding suggests that reduction of bcl-2 protein in gastric cancers, and possibly also in a variety of other tumors, may be a novel and rational approach to improve photosensitivity and the treatment outcome.

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“…The analysis was performed on three samples and the average values are reported in Table 5. In particular, according to the literature [23], the signal at 8.0 ppm was ascribed to 1H of the linear Fries rearrangement products, while the signal at 8.2 ppm was ascribed to the branched Fries adducts. Both integrals were compared with that of the signals between 6.7 and 7.9 ppm due to BPA (8H).…”

Section: Fries Rearrangement Contentmentioning

confidence: 63%

“…The amount of linear and branched Fries groups has been measured according to a method employing 1 H-NMR analysis, as reported in the literature [23] (Fig. 9).…”

Section: Fries Rearrangement Contentmentioning

confidence: 99%

Solid state polymerization of bisphenol A polycarbonate: Effect of the crystallization method and polymerization conditions

Colonna

Fiorini

2014

Polymer Engineering & Sci

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A study on the effect of the crystallization method on the solid state polymerization (SSP) process of bisphenol A polycarbonate has been performed. Prepolymer samples were crystallized via four different techniques (solvent induced, shear induced, organic salt induced, and thermal crystallization) and SSP progress was checked by measuring the molecular weight increase. The fastest polymerization rate was obtained with prepolymers crystallized with acetone. The reaction rates were correlated with the crystallinity and plasticization of solvents, which both affected the chain mobility. The experiments conducted using different sweep gas flow rates and different particle sizes showed that, for the acetone‐crystallized prepolymers, the reaction rate was limited by the by‐product diffusion inside the polymer particles and from the surface of the particles into the sweep gas. 1H‐nuclear magnetic resonance analysis proved that polymers prepared through a solid state process had a consistently lower content of Fries rearrangement by‐products with respect to commercial samples obtained by standard melt polycondensation methods. POLYM. ENG. SCI., 55:1024–1029, 2015. © 2014 Society of Plastics Engineers

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Zur Genealogie E. B. Christoffels

Cited by 6 publications

References 0 publications

Trained vs. untrained searchers' interaction with search features in digital libraries: A case study

Trained vs. untrained searchers' interaction with search features in digital libraries: A case study

Antisense Bcl-2 Retrovirus Vector Increases the Sensitivity of a Human Gastric Adenocarcinoma Cell Line to Photodynamic Therapy

Solid state polymerization of bisphenol A polycarbonate: Effect of the crystallization method and polymerization conditions

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