Zur Histochemie von Harnblasen-Papillomen der Ratte, induziert durch Dibutylnitrosamin

Kunze, Ekkehard; Schauer, A.; Calvoer, R.

doi:10.1007/bf01185752

Cited by 14 publications

(2 citation statements)

References 3 publications

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“…Male and female rats of various strains were exposed via drinking water (5–75 mg/kg bw per day) or gavage (3.9 mg/kg bw per day) to NDBA for about 21–30 weeks (Druckrey et al, 1967 ; Kunze et al, 1969 ; Kunze and Schauer, 1971 ; Okajima et al, 1971 ; Ito, 1973 ; Lijinsky et al, 1983 ). All studies reported on the development of tumours in the urinary epithelium, which were specified as benign papilloma or transitional cell carcinoma by some authors.…”

Section: Assessmentmentioning

confidence: 99%

Risk assessment of N‐nitrosamines in food

Schrenk¹,

Bignami²,

Bodin³

et al. 2023

EFS2

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EFSA was asked for a scientific opinion on the risks to public health related to the presence of Nnitrosamines (N-NAs) in food. The risk assessment was confined to those 10 carcinogenic N-NAs occurring in food (TCNAs), i.e. NDMA, NMEA, NDEA, NDPA, NDBA, NMA, NSAR, NMOR, NPIP and NPYR. N-NAs are genotoxic and induce liver tumours in rodents. The in vivo data available to derive potency factors are limited, and therefore, equal potency of TCNAs was assumed. The lower confidence limit of the benchmark dose at 10% (BMDL 10 ) was 10 μg/kg body weight (bw) per day, derived from the incidence of rat liver tumours (benign and malignant) induced by NDEA and used in a margin of exposure (MOE) approach. Analytical results on the occurrence of N-NAs were extracted from the EFSA occurrence database (n = 2,817) and the literature (n = 4,003). Occurrence data were available for five food categories across TCNAs. Dietary exposure was assessed for two scenarios, excluding (scenario 1) and including (scenario 2) cooked unprocessed meat and fish. TCNAs exposure ranged from 0 to 208.9 ng/kg bw per day across surveys, age groups and scenarios. 'Meat and meat products' is the main food category contributing to TCNA exposure. MOEs ranged from 3,337 to 48 at the P95 exposure excluding some infant surveys with P95 exposure equal to zero. Two major uncertainties were (i) the high number of left censored data and (ii) the lack of data on important food categories. The CONTAM Panel concluded that the MOE for TCNAs at the P95 exposure is highly likely (98-100% certain) to be less than 10,000 for all age groups, which raises a health concern.

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Section: Assessmentmentioning

confidence: 99%

Risk assessment of N‐nitrosamines in food

Schrenk¹,

Bignami²,

Bodin³

et al. 2023

EFS2

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“…Durch histochemische Untersuchungen an tiercxperimentell induzierten Blasentu moren konnte eine spezifische Enzymkon stellation nachgewiesen werden, die schon in der prämalignen Phase der Tumorentstehung irreversibel auftritt [Kunze et al, 1969[Kunze et al, , 1970Kunze und Schauer, 1971;Ito, 1976;Stiller und Rauscher, 1971;Radomski et al, 1978] Kunze et al" 1969;Kunze und Schauer, 1971;Schauer et al" 1971;Stiller und Rauscher, 1971;Ito, 1976;Radomski et al, 1978] …”

unclassified

Histochemische Untersuchungen an menschlichen Har nblasentumoreni

Aeikens¹

1981

Urol Int

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The histochemical enzyme activity of alkaline phosphatase, nonspecific esterase, 5-nucleotidase, β-glucuronidase, glucose-6-phosphatase, succinate dehydrogenase, and glucose-6-phosphate dehydrogenase in human bladder cancer was investigated. Tumors of 84 patients, classified into grades I–III according to the WHO classification, were compared with 12 normal and 16 inflamed bladder epithelia. As a rule, loss of alkaline phosphatase activity and a decrease of nonspecific esterase activity was found in most of these tumors. The activity of β-glucuronidase was decreased and compared with normal tissue, also the activity of 5-nucleotidase. The succinate dehydrogenase activity in tumor tissue was frequently increased, whereas glucose-6-phosphate dehydrogenase did not show any significant reaction.

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Development of Urinary Bladder Cancer in the Rat

Kunze¹

1979

Current Topics in Pathology

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Zur Histochemie von Harnblasen-Papillomen der Ratte, induziert durch Dibutylnitrosamin

Cited by 14 publications

References 3 publications

Risk assessment of N‐nitrosamines in food

Risk assessment of N‐nitrosamines in food

Histochemische Untersuchungen an menschlichen Har nblasentumoreni

Development of Urinary Bladder Cancer in the Rat

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