Zur Kenntnis der Urocaninsäure

Edlbacher, S.; Heitz, Fr.

doi:10.1515/bchm2.1943.279.1-2.63

Cited by 24 publications

(3 citation statements)

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“…Cis-UCA was prepared by irradiation of an alcoholic solution of 2 % trans-UCA under N2 with a low pressure mercury lamp for JO h (7). Cis-UCA was isolated and purified by recrystallization in water and alcohol.…”

Section: Lymphocyte Transformation Testmentioning

confidence: 99%

cis-Urocanic acid does not inhibit mitogen induced lymphocyte transformation in man

Higaki,

Hauser,

Siegenthaler

et al. 1986

Acta Derm Venereol

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Urocanic acid (UCA) is a photoreceptor in the epidermis which absorbs UVB. To elucidate the role of UCA as an immunomodulator in the mechanism of immune suppression which occurs after UV irradiation in human, we studied the effect trans-UCA as well as that of its UV induced cis-isomer (cis-UCA) on mitogen induced lymphocyte transformation and on delayed type responses elicited by intradermal testing of a standardized battery of microbial antigens. No inhibitory effect was seen either in vitro or in vivo. Our negative results, both in vivo and in vitro, suggest that if UCA and UCA photoproducts exert an immunomodulatory effect, their effect should be analysed by a more subtle evaluation of the immune system.

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Section: Lymphocyte Transformation Testmentioning

confidence: 99%

cis-Urocanic acid does not inhibit mitogen induced lymphocyte transformation in man

Higaki,

Hauser,

Siegenthaler

et al. 1986

Acta Derm Venereol

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“…Isomasisation ' Edlbacher and Hertz [4] and others [8,9] have found that synthetic urocanic acid and its salts have higher melting points than do the corresponding compounds obtained after ultraviolet or sunlight irradiation of the synthetic urocanic acid. By analogy with fumaric and maleic acids and with o-hydroxy cinnamic acids, they show synthetic urocanic acid to be trans and the compound obtained by its irradiation to be cis.…”

Section: Chromatography Of the Mixed Isomersmentioning

confidence: 99%

“…The absorption spectra of eluted urocanic acid and of the synthetic compound were the same after corrections were made for this impurity. Nitric, picric, and picrolonic acids have been used by others (4] in identifying urocanic acid, but these were unsatisfactory with the eluate. The use of flavianic acid by Vickery [15,16] in an analytic system for basic amino acids suggested its use for the small amount of urocanic acid in the eluates in the presence of paper impurities.…”

Section: Chromatography Of the Mixed Isomersmentioning

confidence: 99%

Isolation and Identification of Urocanic Acid Found in Extracts of Raw Wool

Binkley

Jones

1959

Textile Research Journal

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IN A study of the natural causes of nonscourable discoloration of wool, the question of the presence of urocanic acid in suint was raised.Neither the action of alkali as discussed by Serra and de Matco [12] nor of bacterial pigments studied by Seddon [11] and by Fraser and Mulcock [5] will account for the experimentally induced discoloration when wool is held in the presence of suint at 55° C. and at high humidities; the color is due to neither alkali nor bacterial pigments. As it is nonscourable, it is not caused by lanaurin, the deeply colored suint component discussed by Rimington and Stewart EIOI. It was thought possible that urocanic acid, which has been shown byZenisek and Kral E18] to be present in human perspiration, might also be present in suint and might, either directly or through interaction with other suint components, cause or contribute significantly to this experimental wool discoloration and be involved in natural wool discoloration. Urocanic acid alone on wool when held at 55° C. at high humidities causes discoloration, though less than that caused by suint under the same conditions. However, the concentration of urocanic 1 A laboratory

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Bibliography

1953

Chemistry of Heterocyclic Compounds: A Series of Monographs

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Zur Kenntnis der Urocaninsäure

Cited by 24 publications

References 0 publications

cis-Urocanic acid does not inhibit mitogen induced lymphocyte transformation in man

cis-Urocanic acid does not inhibit mitogen induced lymphocyte transformation in man

Isolation and Identification of Urocanic Acid Found in Extracts of Raw Wool

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