Zur Problematik der Bromsulphalein-Clearance als Leberfunktionsprüfung

Neumayr, A; Parzer, O; Vetter, H

doi:10.1055/s-0028-1115608

Cited by 13 publications

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“…Even in normal cases the rate of BSP excretion into the bile is consistently below the rate of BSP removal by the liver parenchyma (16,17); since the limiting factor would be the volume of the BSP space within the liver, after some time following injection the removal rate must slow down to the rate of biliary excretion. In cases with hepatic dysfunction it is likely that the biliary excretion rate as well as the volume of the BSP space is decreased and, in fact, the "saturation effect" has been observed more frequently in patients with hepatic disorders (18)(19)(20). In the present series the "saturation effect" has been seen after a single BSP dose in five cases.…”

Section: Resultssupporting

confidence: 51%

Comparison of Liver Blood Flow Values Estimated by the Bromsulphalein and by the Radiogold Method

Vetter¹,

Grabner²,

Höfer³

et al. 1956

J. Clin. Invest.

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In a previous paper (1) we have described a method of following the disappearance of intravenously injected colloidal radioactive gold from the circulation in man and have discussed the possibilities of calculating liver blood flow from the disappearance rate constant as the fraction of blood volume perfusing the liver per unit time.If liver blood flow values estimated in this way could be demonstrated to be correct this method should have many advantages over other methods currently in use: it does not require hepatic vein catheterization; with only one blood sample withdrawn for determination of hematocrit and plasma volume, it does not involve any undue blood loss to the patient; being exceedingly simple and mechanized to a considerable extent by the use of counting rate meters and recorders, it can be carried out by a single technician; it can be repeated several times without exposing the patient to any risk thereby enabling observation of changes in hepatic circulation over any period of time.Hepatic blood flow values estimated by this method in 25 normal subjects (18 males and 7 females) were found to average 1310 ml. per min.(1) and thus to be somewhat lower but still within the range of normal values reported by other groups who used the bromsulphalein or other methods. However, even this difference might not have been a real one. In this laboratory the observed venous hematocrit is corrected for trapped plasma and for the uneven distribution of cells and plasma within the whole body circulation. with the average normal radiogold results, appear to have used any correction of the hematocrit. It might, therefore, well be that the difference between average hepatic blood flows estimated by these two methods in different groups of normal subjects has been caused by the difference in the methods of calculating blood volume.However, a few experiments designed to investigate the efficiency of the liver phagocytes to remove the colloid particles from the blood passing through the liver, indicated that the radiogold method underestimates the true hepatic blood flow by almost 20 per cent (1). If this is true a direct comparison of BSP and radiogold results should reveal a real difference in the calculated flow values. Simultaneous estimations of hepatic blood flow by these two methods were, therefore, performed in 15 subjects the results of which are presented in this paper. METHODSMaterial. The subj ects studied were hospitalized patients in whom for diagnostic purposes a heart or hepatic vein catheterization was warranted. Therefore, none of the subjects could be considered to be "normal."Catheterization.

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Section: Resultssupporting

confidence: 51%

Comparison of Liver Blood Flow Values Estimated by the Bromsulphalein and by the Radiogold Method

Vetter¹,

Grabner²,

Höfer³

et al. 1956

J. Clin. Invest.

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“…Ebenso wie MUHE (1951) konnten wir bei den von uns untersuchten Schweinen keine gesicherte Korrelation zwischen dein Gewicht der Tiere und dem Bilirubinspiegel feststellen (r = -0,17). Die Bromsulphaleinwerte waren bei unseren Untersuchungen mit den Gesamtbilirubinwerten nur schwach korreliert (r = 0,29')), was mit den Angaben von SCHRAGEL ( ) und WENDLER (1957 , 1954;SCHRAGEL, 1956). Bei Tier Nr.…”

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Der Bromsulphaleintest zur klinischen Leberfunktionsprüfung beim Schwein

Pfeiffer

2010

Zentralblatt Für Veterinärmedizin Reihe A

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Zusammenfassung An 55 Schweinen wurde der Bromsulphaleintest nach der klassischen Methode ausgeführt. Nach Verabreichung von 5 mg Bromsulphalein/kg KGW wurde nach einer Testdauer von 15 Minuten die Retention in % errechnet. Unterschiede zwischen den Testergebnissen bei der Verwendung von Plasma oder Serum bzw. bei direkter oder indirekter Messung der Proben konnten nicht festgestellt werden. Aus Gründen der Einfachheit der Laboratoriumsarbeit ist deshalb die direkte Messung von Plasmaproben vorzuziehen. Durch die statistische Betrachtung der Normalwerte lassen sich die Einflüsse des Plasmavolumens, Herzminutenvolumens und Lebergewichts auf das Testergebnis bei den einzelnen Altersgruppen weitgehend ausschalten. Für Schweine bis 100 kg KGW sind Bromsulphaleinretentionen von ˜3–4% noch normal, während für Schweine von 100 bis 200 kg Retentionswerte von ˜ 4–5% noch als normal angesehen werden können. Mit Hilfe des Bromsulphaleintestes lassen sich ebenso wie beim Menschen auch beim Schwein Störungen der Exkretionsfunktion der Leber sicher diagnostizieren. Summary Bromsulphthalein as a clinical liver function test in the pig This test was carried out in the classical way on 55 pigs. After giving 5 mg. of bromsulphthalein per kg. bodyweight, its retention was determined as a percentage 15 minutes later. No differences were found between using plasma or serum or between direct and indirect measurement. On grounds of simplicity in the laboratory a direct test measurement on plasma samples is therefore preferable. Statistical consideration of normal values enables the influence of plasma volume, heart minute volume and liver‐weight to be taken into proper account in different age groups. For pigs of 100 kg. bodyweight, bromsulphthalein retention values of ˜ 3–4% are within the normal range and for pigs weighing 100–200 kg., values of ˜ 4–5% can also be regarded as normal. This test can be used as a reliable method of determining the excretory function of the liver in the pig, as in man. Résumé Le test de la bromosulfophtaléine pour une détermination de la fonction hépatique chez le porc On pratique le test de la bromosulfophtaléine selon la méthode classique sur 55 porcs. On administre 5 mg de bromosulfophtaléine/kg de poids du corps, puis on calcule la rétention en pourcents, après avoir laissé agir le test pendant 15 minutes. On n'a pas observé de différences dans les résultats du test en employant le plasma ou le sérum, ni en procédant à des mesures directes ou indirectes des échantillons. Pour des raisons de simplification du travail de laboratoire, il est donc préférable d'employer la mesure directe sur échantillons de plasma. Par une appréciation statistique des valeurs normales, on peut éliminer pour une grande part les influences du volume plasmatique, du volume‐minute cardiaque et du poids du foie sur le résultat du test dans les différentes catégories d'âge. Chez les porcs pesant jusqu'à 100 kg, des valeurs de rétention de bromosulfophtaléine d'env. 3–4% sont encore normales, alors que chez les porcs de 100 à 20...

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Die Pathologie der Leberausscheidung

Kühn¹

1959

Hilfsmechanismen Des Stoffwechsels II

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Zur Problematik der Bromsulphalein-Clearance als Leberfunktionsprüfung

Cited by 13 publications

References 0 publications

Comparison of Liver Blood Flow Values Estimated by the Bromsulphalein and by the Radiogold Method

Comparison of Liver Blood Flow Values Estimated by the Bromsulphalein and by the Radiogold Method

Der Bromsulphaleintest zur klinischen Leberfunktionsprüfung beim Schwein

Die Pathologie der Leberausscheidung

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