Zur Problematik des akuten Mesenterialarterienverschlusses*

Schennach, W; Dorfmann, A

doi:10.1055/s-0028-1099043

Cited by 2 publications

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“…As a consequence of this mucosal injury, there may be a massive loss of plasma and fluid into the gut lumen (2) but also an increased passage of bacteria and other components from the gut lumen into the circulation (2). For instance, Fine (3) showed that ischaemia of the dog intestine increased the mucosal permeability to gut bacteria, and we recently found that ischaemia of the rat intestine causes an increased permeability to larger molecules such as dextran 3000 (T. Otamiri, R. Sjodahl, C. Tagesson.…”

Section: 1131-1136mentioning

confidence: 99%

Lysophosphatidylcholine Potentiates the Increase in Mucosal Permeability after Small-Intestinal Ischaemia

Otamiri

Sjödahl

Tagesson

1986

Scandinavian Journal of Gastroenterology

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The influence of lysophosphatidylcholine (lysoPC), taurodeoxycholate (TDC), and taurochenodeoxycholate (TCDC) on the permeability properties of the ischaemic small-intestinal mucosa was investigated. We first studied the effect of ischaemia alone, then of lysoPC, TDC, or TCDC alone, and finally of ischaemia together with lysoPC, TDC, or TCDC on the permeability to sodium fluorescein in a ligated loop of the distal ileum in the rat. Longer periods of ischaemia alone (10 min or more) caused increased permeability, as did high concentrations (10 mM) of any of the agents. Low concentrations (1 mM) of lysoPC alone did not alter the gut permeability, but it significantly potentiated the increased permeability caused by 30 min of ischaemia. In contrast, 1 mM TDC or TCDC did not influence the permeability after 30 min of ischaemia. These findings imply that the ischaemic small intestine may be damaged by small amounts of lysoPC, with increased absorption of potentially pathogenic compounds as a possible consequence. They also point to the possibility that endogenously formed lysoPC may play a role in the mucosal damage and the increased permeability that occurs after small-intestinal ischaemia.

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Section: 1131-1136mentioning

confidence: 99%

Lysophosphatidylcholine Potentiates the Increase in Mucosal Permeability after Small-Intestinal Ischaemia

Otamiri

Sjödahl

Tagesson

1986

Scandinavian Journal of Gastroenterology

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Zur Bedeutung laborchemischer Parameter f�r die Diagnostik des Mesenterialinfarktes

Schlosser

Rehner

Mau

et al. 1980

Langenbecks Arch Chiv

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A laparotomy was performed on 23 dogs with and without ligation of the mesenteric artery. Twenty-eight laboratory parameters of blood samples taken immediately and then every two hours after the operations were checked for systematic trends. The analysis of variance showed some differences between both groups. It was impossible to use the individual results of this investigation for a general diagnostic approach. Difficult and long-lasting biochemical investigations are of dubious value since time loss is one of the most important problems in mesenteric occlusion. Indications for invasive diagnostic procedures and for laparotomy should not be postponed; they should depend on the different aspects of clinical symptoms, as it is practised now.

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Zur Problematik des akuten Mesenterialarterienverschlusses*

Cited by 2 publications

References 0 publications

Lysophosphatidylcholine Potentiates the Increase in Mucosal Permeability after Small-Intestinal Ischaemia

Lysophosphatidylcholine Potentiates the Increase in Mucosal Permeability after Small-Intestinal Ischaemia

Zur Bedeutung laborchemischer Parameter f�r die Diagnostik des Mesenterialinfarktes

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