Zur Reaktivität von 2‐Hydrazino‐1,3,4‐thiadiazinen

Cyclocondensations of Substituted Thiosemicarbazides with 2-Bromo- 1,2-diphenylethan-1-one

“…The free base was obtained from the filtrate by addition of a conc. solution of NH 3 . The crude product contains 2.…”

“…Method B: A mixture of 4-nitrobenzaldehyde-4-methylthiosemicarbazone (2.38 g, 10 mmol) and 2-bromo-1,2-diphenylethan-1-one (2.75 g, 10 mmol) in EtOH (100 mL) was refluxed for 2 h. After cooling, the mixture was neutralized with NH 3 …”

Synthesis of Imidazo[2,1‐b][2H‐1,3,4]thiadiazines and 1,2,4‐Triazolo[3,4‐b][2H‐1,3,4]thiadiazines

“…1,2,[ 2H-1,3,4]thiadiazines were prepared by cyclization of 4-amino-5-sulfanyl-l,2,4-triazoles with phenacyl bromides. INTRODUCTION 1,3,Thiadiazines are of considerable biochemical and pharmacological relevance. Several 2-amino-1,3,4-thiadiazine derivatives are important matrix metalloproteinase inhibitors [1,2].…”

“…Several 2-amino-1,3,4-thiadiazine derivatives are important matrix metalloproteinase inhibitors [1,2]. 2-Alkylimino-1,3,4-thiadiazines and 2-alkyamino-1,3,4-thiadiazines are used as cardiotonic and spasmolytic agents [3][4][5][6][7][8]. 1,3,4-Thiadiazin-2-ones are cardiotonics with calcium sensitizing activity [9][10][11].…”

“…3-Phenylazo-1H-4,2,1thiadiazine is an agent for the treatment of deficient bone growth [12]. 3,3,ones are phospho-diesterase IV inhibitors that can be used for the treatment of tumors and AIDS [13,14]. 3,, N-morpholinyl-1,3,4-thiadiazines, N-thiomorpholinyl-1,3,4-thiadiazines or N-piperidinyl-1,3,4-thiadiazines [16] exhibit antithrombotic activities.…”