“…In an open trial, Barth (1968) reported 'very good' or 'satisfactory' clinical results with mefruside in 34 obstetric patients with oedema of pregnancy, in 20 out of 24 patients with premenstrual syndrome, in 16 out of 22 with oedema accompanying obesity and in all 10 with oedema associated with venous insufficiency. A dose of 25 mg daily or on alternate days was usually adequate in the obstetric patients whilst in the gynaecological cases the initial dose was usually 75 mg daily reducing to 50 mg daily or on alternate days according to the clinical response.…”