Zur Tumorzelldiagnostik im Liquor cerebrospinalis

Bammer, Hans

doi:10.1007/bf00242747

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…Cells labelled in the autoradiographs of such CSF specimens--small to medium sized round mononuclear cells and some histiocytes--are probably of no diagnostic significance, comparable to the occasional finding of mitotic ceils [ 1,5,26] in otherwise normal CSF specimens.…”

Section: Discussionmentioning

confidence: 98%

“…Total cell counts are stated as per p.1. For morphological differentiation, sedimentation chamber preparations were made using Bammer's [ 1] method: 2 ml of CSF were put into the chamber for spontaneous sedimentation over approximately 20 min. With some specimens a cytocentrifuge (Cytospin Shandon) was used for cell preparation instead of the sedimentation chamber method.…”

Section: Cytological Examinationmentioning

confidence: 99%

“…Sayk [18] and other authors [1,4,21,24] found mitotic CSF cells in bacterial and viral meningitis and also in some chronic inflammatory diseases. Even in the absence of mitotic forms, some authors described proliferating CSF cells, using only morphological criteria, e.g.…”

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confidence: 98%

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Autoradiographic demonstration of proliferating cells in cerebrospinal fluid

1977

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The proliferative activity of cells, isolated from 82 human CSF specimens, was examined by 3H-thymidine autoradiography. High labelling indices (LI) were found in acute viral meningitis (up to 8 per cent) and radiculitis (up to 6 per cent). CSF cell proliferation was also shown in the subacute stages of viral diseases and in other inflammatory processes (LI ranging from 0.5 per cent to 3 per cent). Most of the cells labelled from these CSF specimens were large lymphocytes, "lymphoid cells" and plasmacytes. Their presence in CSF is presumed to indicate an immune reaction. By the demonstration of a proliferative activity of these cells, aseptic inflammatory processes can be differentiated from "unspecific" pleocytosis. Because of a correlation between the LI of CSF cells and the stages of some inflammations, this method is suggested for an assessment of pregression or remission of chronic processes, e.g. "chronic meningitis" and multiple sclerosis. It can also be used in experimental research: the same type of mononuclear cells was labelled after having been cultured for 23 hours prior to the incubation with 3H-thymidine. Proliferating tumor cells as well as proliferating non-neoplastic mononuclear cells were demonstrated in CSF from various neoplastic diseases. In the clinical diagnosis of these processes, the method is of limited value. It proved very useful, however, for an assessment of the therapeutic effects of intrathecal cytostatic therapy. CSF specimens from non-inflammatory and non-neoplastic diseases regularly contained very few proliferating cells (LI: less than 0.1).

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Section: Discussionmentioning

confidence: 98%

Section: Cytological Examinationmentioning

confidence: 99%

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Autoradiographic demonstration of proliferating cells in cerebrospinal fluid

1977

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“…Bischoff (1961) gives no percentage but says 'dass man auf ein Objekttrager eine erhebliche Zahl-gunstigenfalls mehrere hundertgut erhaltene Zellen zu Gesicht bekommt'. Bammer (1963) states that his modification of Sayk's method gives a 20to 30% yield. Enestrom claims that repeated sedimentation of the same sample with the suction chamber method will give a yield of 80 to 90% of the cells (personal communication).…”

Section: Examination Of Stained Cells In May-grunewald-mentioning

confidence: 99%

A new method for the cytological examination of the cerebrospinal fluid.

Sörnäs¹

1967

Journal of Neurology, Neurosurgery & Psychiatry

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“…The sedimentations were prepared by Sayk's (23) method as modified by Bammer (2), and stained with May-Griinwald-Giemsa. For each specimen, the per centage of neutrophilic and eosinophilic granulocytes, lymphocytes, plasma cells, monocytes and histiocytes was determined.…”

Section: Cytological Studiesmentioning

confidence: 99%

Zoster Meningitis and Radiculomeningitis after Tick Bite

Shoji¹,

Dommasch²

1979

Eur Neurol

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Cytological changes in 9 samples of cerebrospinal fluid (CSF) from 5 patients with zoster meningitis and 12 samples from 5 patients with radiculomeningitis after tick bite were examined. 5 days after the onset of the skin eruption, the CSF cells in zoster meningitis consisted of many mononuclear blast forms – large lymphocytes and ‘immature’ plasma cells. 11–15 days after the onset of the skin rash, they were replaced by small lymphocytes, some ‘mature’ plasma cells and monohistiocytes. In radiculomeningitis after tick bite, however, the CSF cells examined 10–21 days after the onset of radicular pain consisted of many large lymphocytes, immature plasma cells and a few neutrophils. From these findings, it might be suggested that the acute meningeal reaction of zoster meningitis subsides within about 1 week after the onset of the skin rash, but that of radiculomeningitis after tick bite continues at least for 2–3 weeks after the onset of radicular pain.

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Zur Tumorzelldiagnostik im Liquor cerebrospinalis

Cited by 8 publications

References 9 publications

Autoradiographic demonstration of proliferating cells in cerebrospinal fluid

Autoradiographic demonstration of proliferating cells in cerebrospinal fluid

A new method for the cytological examination of the cerebrospinal fluid.

Zoster Meningitis and Radiculomeningitis after Tick Bite

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