Zur Wirkung des Phenothiazink�rpers Atosil auf das Schmerzgeschehen

Bente, D

doi:10.1007/bf00249271

Cited by 7 publications

(10 citation statements)

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“…Systematic EEG investigations of drugs started with the discovery of the first "classical" psychotropic compound, chlorpromazine. As early as 1954, it was reported that chlorpromazine, the first classical neuroleptic (major tranquilizer), produced systematic effects on human EEG (Bente and Itil, 1954). It was observed that chlorpromazine-induced changes are different from promethazine, a nonpsychotropic phenothiazine (Fig.…”

Section: Classification Of Drugs By "Qualitative" Eeg Evaluationmentioning

confidence: 99%

The discovery of psychotropic drugs by computer‐analyzed cerebral bioelectrical potentials (CEEG)

Turan

1981

Drug Development Research

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Itil, T.M.:The Discovery of psychotropic drugs by computer-analyzed cerebral bioelectrical potentials (CEEG). Drug Dev. Res. 1:373-407, 1981.The psychotropic properties of nine compounds were discovered in healthy subjects based on the effects of computer-analyzed cerebral bioelectrical potentials or computer-analyzed electroencephalograms (CEEG). Quantitative pharmaco-EEG (QPEEG) studies demonstrated that CEEG profiles of mianserin (GB-94), GC-46, cyclacozine, mesterolone, and estradiol valerate, resembled the CEEG profiles of tricyclic antidepressants. CEEG profiles of d-and I-norgestrel and cyproterone acetate showed similarities to benzodiazepine anxiolytics, and profiles of lisuride hydrogen maleate resembled psychostimulant compounds. Thus, antidepressant, anxiolytic, and "psychostimulant" effects were predicted for these compounds. Subsequent clinical trials confirmed the antidepressant effects of mianserin, GC-46, and mesterolone in depressed patients; the anxiolytic effects of I-norgestrel and cyproterone acetate in anxiety syndromes; and the "psychostimulant" properties of lisuride hydrogen maleate in the "geriatric" population. However, animal pharmacology and biochemical investigations failed to predict any psychotropic properties for these compounds.

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Section: Classification Of Drugs By "Qualitative" Eeg Evaluationmentioning

confidence: 99%

The discovery of psychotropic drugs by computer‐analyzed cerebral bioelectrical potentials (CEEG)

Turan

1981

Drug Development Research

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“…CPZ was introduced in 1954 in North America by two Canadian psychiatrists Roland Saucier and Heinz Lehmann (see Stip, 2015). By the end of 1955, there were also reports describing use of CPZ from Switzerland, Germany, Hungary, Latin America, Australia, Russia, and the United States (Bente and Itil, 1954;Sal et al, 1954;Staehelin, 1954;Kardos and Pertorini, 1955;Webb, 1955). CPZ was marketed in the United States as Thorazine by SmithKline, in France and England as Largactil by May and Baker (Stip, 2015), and in Japan by the name of Cotomin.…”

Section: Discovery Of Chlorpromazinementioning

confidence: 99%

The Large Action of Chlorpromazine: Translational and Transdisciplinary Considerations in the Face of COVID-19

et al. 2020

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Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome (SARS) in humans that is caused by SARS-associated coronavirus type 2 (SARS-CoV-2). In the context of COVID-19, several aspects of the relations between psychiatry and the pandemic due to the coronavirus have been described. Some drugs used as antiviral medication have neuropsychiatric side effects, and conversely some psychotropic drugs have antiviral properties. Chlorpromazine (CPZ, Largactil®) is a well-established antipsychotic medication that has recently been proposed to have antiviral activity against SARS-CoV-2. This review aims to 1) inform health care professionals and scientists about the history of CPZ use in psychiatry and its potential anti- SARS-CoV-2 activities 2) inform psychiatrists about its potential anti-SARS-CoV-2 activities, and 3) propose a research protocol for investigating the use of CPZ in the treatment of COVID-19 during the potential second wave. The history of CPZ’s discovery and development is described in addition to the review of literature from published studies within the discipline of virology related to CPZ. The early stages of infection with coronavirus are critical events in the course of the viral cycle. In particular, viral entry is the first step in the interaction between the virus and the cell that can initiate, maintain, and spread the infection. The possible mechanism of action of CPZ is related to virus cell entry via clathrin-mediated endocytosis. Therefore, CPZ could be useful to treat COVID-19 patients provided that its efficacy is evaluated in adequate and well-conducted clinical trials. Interestingly, clinical trials of very good quality are in progress. However, more information is still needed about the appropriate dosage regimen. In short, CPZ repositioning is defined as a new use beyond the field of psychiatry.

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“…Unabhängig davon, ob die Vigilanzbedingungen während der EEG-Ableitung möglichst konstant. gehalten werden, so daß Stationarität etwa wahrend einer fünfminütigen Ableitung vorausgesetzt werden kann (23,38), oder ob sie systematisch variiert werden, hat das Wach-EEG schon in den 50er und 60er Jahren die Möglichkeiten zur Unterscheidung zwischen den Wirkungen von Stimulantia des Amphetamintyps und denen von Neuroleptika, Antidepressiva und Tranquilizern geführt (3,5,13,16,17,19,24,25,28,35,44…”

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Beispiele für die Projektion von Substanzwirkungen typischer Psychopharmaka auf eine elektrophysiologische Meßebene

Herrmann¹,

Kubicki²

1981

Klin Neurophysiol

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Zur Wirkung des Phenothiazink�rpers Atosil auf das Schmerzgeschehen

Cited by 7 publications

References 0 publications

The discovery of psychotropic drugs by computer‐analyzed cerebral bioelectrical potentials (CEEG)

The discovery of psychotropic drugs by computer‐analyzed cerebral bioelectrical potentials (CEEG)

The Large Action of Chlorpromazine: Translational and Transdisciplinary Considerations in the Face of COVID-19

Beispiele für die Projektion von Substanzwirkungen typischer Psychopharmaka auf eine elektrophysiologische Meßebene

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