Zusammenhang zwischen myokardialem Bridging und letalen ventrikulären Arrhythmien bei Patienten mit hypertropher Kardiomyopathie: die HCM-MB-Studie

Güner, Ahmet; Atmaca, Sezgin; Balaban, İ̇smail; Türkmen, İrem; Çeneli, Doğancan; Türkvatan, Aysel; Oner, Ender; Surgit, Özgür; Güler, Arda; Uzun, Fatih; Güler, Gamze Babur; Kahraman, Serkan; Pala, Selçuk; Havan, Nuri; Yıldız, Mustafa; Ertürk, Mehmet

doi:10.1007/s00059-023-05171-9

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…In some rare cases, major cardiac events or life-threatening ventricular arrhythmias may occur during extreme exercise [8][9][10]. The presence of MB was reported to increase the risk of fatal arrhythmia among those with hypertrophic cardiomyopathy and those who underwent implantable cardioverter defibrillator or heart transplantation [10][11][12]. A significantly elevated risk of in-hospital death was demonstrated among Takotsubo cardiomyopathy patients with versus without MB [13].…”

Section: Introductionmentioning

confidence: 99%

Identification of Genetic Variants Associated with Severe Myocardial Bridging through Whole-Exome Sequencing

Yang,

Ting,

Lin

et al. 2023

JPM

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Myocardial bridging (MB) is a congenital coronary artery anomaly and an important cause of angina. The genetic basis of MB is currently unknown. This study used a whole-exome sequencing technique and analyzed genotypic differences. Eight coronary angiography-confirmed cases of severe MB and eight age- and sex-matched control patients were investigated. In total, 139 rare variants that are potentially pathogenic for severe MB were identified in 132 genes. Genes with multiple rare variants or co-predicted by ClinVar and CADD/REVEL for severe MB were collected, from which heart-specific genes were selected under the guidance of tissue expression levels. Functional annotation indicated significant genetic associations with abnormal skeletal muscle mass, cardiomyopathies, and transmembrane ion channels. Candidate genes were reviewed regarding the functions and locations of each individual gene product. Among the gene candidates for severe MB, rare variants in DMD, SGCA, and TTN were determined to be the most crucial. The results suggest that altered anchoring proteins on the cell membrane and intracellular sarcomere unit of cardiomyocytes play a role in the development of the missed trajectory of coronary vessels. Additional studies are required to support the diagnostic application of cardiac sarcoglycan and dystroglycan complexes in patients with severe MB.

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Section: Introductionmentioning

confidence: 99%

Identification of Genetic Variants Associated with Severe Myocardial Bridging through Whole-Exome Sequencing

Yang,

Ting,

Lin

et al. 2023

JPM

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show abstract

“… 20 , 37 However, with one disturbing recent report of MB being an independent predictor of fatal arrhythmia in patients with HCMP. 38 At the same time, in those free of HCMP, Zhang et al 36 found a positive correlation between systolic compression and major adverse coronary events and proximal to MB atherosclerosis.…”

mentioning

confidence: 95%

“… 20 , 37 No entanto, com um relatório recente perturbador de PM sendo um preditor independente de arritmia fatal em pacientes com HCMP. 38 Ao mesmo tempo, naqueles livres de CMPH, Zhang et al, 36 encontraram correlação positiva entre compressão sistólica e eventos coronarianos adversos maiores e aterosclerose proximal à PM.…”

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Parapid,

Kanjuh

2023

Arquivos Brasileiros De Cardiologia

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The Association Between Myocardial Bridging and Hypertrophic Cardiomyopathy and Their Implications on Percutaneous Coronary Intervention Outcomes: A Retrospective Study

Alsughayer,

Alharbi,

Shah

et al. 2024

Current Problems in Cardiology

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Zusammenhang zwischen myokardialem Bridging und letalen ventrikulären Arrhythmien bei Patienten mit hypertropher Kardiomyopathie: die HCM-MB-Studie

Cited by 4 publications

References 37 publications

Identification of Genetic Variants Associated with Severe Myocardial Bridging through Whole-Exome Sequencing

Identification of Genetic Variants Associated with Severe Myocardial Bridging through Whole-Exome Sequencing

Ponte Miocárdica: Amiga, Inimiga ou Ambas?

The Association Between Myocardial Bridging and Hypertrophic Cardiomyopathy and Their Implications on Percutaneous Coronary Intervention Outcomes: A Retrospective Study

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