Zweistufige Mikroverkapselung von Rinderserumalbumin auf Trägerpartikeln in der Hochdruckwirbelschicht

Rosenkranz, K.; Rodríguez‐Rojo, Soraya; Kasper, Manfred; Werther, Joachim; Brunner, Gerd

doi:10.1002/cite.200600119

Chemie Ingenieur Technik

2007

DOI: 10.1002/cite.200600119

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Zweistufige Mikroverkapselung von Rinderserumalbumin auf Trägerpartikeln in der Hochdruckwirbelschicht

K. Rosenkranz

Soraya Rodríguez‐Rojo

Manfred Kasper

et al.

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Supercritical fluid coating of API on excipient enhances drug release

Huang

et al. 2017

Chemical Engineering Journal

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A process to coat particles of active pharmaceutical ingredient (API) onto microcrystalline cellulose (MCC) excipient shows promise as a new way to dosage forms showing enhanced drug release. The process consists of a fluidized bed operated at elevated pressure in which API particles are precipitated from a Supercritical Anti-Solvent process (SAS). MCC particles were used as an excipient in the fluidized bed and collect the SAS-generated API particles. Naringin was selected as the model API to coat onto MCC. A number of operational parameters of the process were investigated: fluidization velocity, coating pressure, temperature, concentration of drug solution, drug solution flow rate, drug mass, organic solvent, MCC mass and size and CO2-to-organic solution ratio. SEM and SPM analyses showed that the MCC particle surfaces were covered with near-spherical nanoparticles with a diameter of approximately 100– 200 nm, substantially smaller than the as-received API material. XRD showed that naringin changed from crystalline to amorphous during processing. The coated particles resulting from the SAS fluidized bed process have a higher loading of API, gave faster release rates and higher release ratios in comparison with those produced using a conventional fluidized bed coating process. The approach could be transferred to other industries where release is important such as agrochemical, cosmetic and food

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Supercritical fluid coating of API on excipient enhances drug release

Huang

et al. 2017

Chemical Engineering Journal

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Zweistufige Mikroverkapselung von Rinderserumalbumin auf Trägerpartikeln in der Hochdruckwirbelschicht

Cited by 1 publication

References 11 publications

Supercritical fluid coating of API on excipient enhances drug release

Supercritical fluid coating of API on excipient enhances drug release

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