Związek depresji z cukrzycą - rola osi podwzgórzowo-przysadkowo-nadnerczowej i przewlekłego zapalenia.

Abstract

Depression and diabetes belong to the most common diseases in the human population. Mood disorders are often diagnosed in patients with chronic diseases, including type 1 and type 2 diabetes. Patients suffering from both diseases have been observed to have poorer blood glucose control, an increased risk of complications and mortality compared to the group with diabetes alone. The association between diabetes and depression is complex. Their frequent cooccurrence may be influenced by psychological factors, hormonal and immunological disorders. In depression, hypothalamo-pituitary-adrenal axis dysregulation is observed, which causes peripheral hypercortisolemia. The excess of cortisol leads to hepatic glycogenolysis and reduction in insulin sensitivity of peripheral tissues. It has been proven that depression is accompanied by chronic subclinical inflammation. In this review we present the data regarding the relation between hypercortisolemia, subclinical inflammation and depression in patients with type 1 and type 2 diabetes.

Comparative assessment of the relationship between emotional factors and quality of life in a group of patients with type 1 and type 2 diabetes – preliminary report

“…The vast majority of them are probably reactive states, as the causal relationship of type 2 diabetes with endogenous depression has not been confirmed, while the inverse relationship is likely [6]. Diagnosis of depression is associated with a 60% risk of developing type 2 diabetes [16][17][18]. As shown by a study of Arroyo, where there was a clear relationship between depression and the risk of type 2 diabetes in a group of women [19].…”