ZWINT is a cancer prognosis and immune infiltration-related biomarker from pan-cancer analysis

Abstract

ZWINT plays an important role in regulating the mitotic checkpoint and cell cycle, and is closely associated with tumor proliferation and migration. Recent studies have shown that high ZWINT expression is associated with poor prognosis in patients with lung adenocarcinoma(LUAD) and Glioblastoma (GBM). Previous analyses of ZWINT were limited to a certain type of cancer, but there has not been a systematic pan-cancer study of ZWINT. We used the TCGA (The Cancer Genome Atlas) project and GTEx data (Genotype-Tissue Expression) to analyze ZWINT expression levels and the correlation with cancer survival prognosis. To understand the underlying biological mechanisms of ZWINT and its relevance to immune infiltration, we systematically analyzed ZWINT-associated genetic alterations, immune infiltration and gene enrichment analysis with different bioinformatics methods. Our study showed that ZWINT mRNA expression was elevated in most human tumors and was significantly increased in the early stages of cancer compared to ZWINT expression in normal tissues.ZWINT high expression is significantly correlated with poor prognosis in most tumors. ZWINT is extensively involved in immune infiltration of tumors. Single cell sequencing data showed that ZWINT was significantly associated with cell cycle, DNA repair, DNA damage, and proliferation. Thus, ZWINT expression correlates with prognosis and immune infiltration in tumor patients. ZWINT may be a potential biomarker for prognosis and an important target for tumor immunotherapy.

Zwint is highly expressed in ovarian cancer and promotes cell proliferation, migration and invasion

“…ZWINT is a crucial constituent of the mitotic spindle checkpoint, which plays a pivotal role in ensuring accurate chromosome segregation during cell division and maintaining genomic stability. [14,15] Recent studies have shown that ZWINT may be involved in the pathogenesis of tumour development and is overexpressed in a variety of malignancies including colon, breast, liver, lung and pancreatic cancers [8,[16][17][18][19][20][21] .However, the regulation of ZWINT in ovarian cancer and its molecular mechanism have not been reported yet. The results of this study showed that ZWINT was significantly highly expressed in ovarian cancer tissues, the higher the expression level of ZWINT, the worse the overall survival and disease-free survival of the patients, which indicates that ZWINT is closely related to the development of ovarian cancer.…”