Zwitterionic hydrogels implanted in mice resist the foreign-body reaction

Zhang, Lei; Cao, Zhiqiang; Bai, Tao; Carr, Louisa R.; Ella-Menye, Jean Rene; Irvin, Colleen A.; Ratner, Buddy D.; Jiang, Shaoyi

doi:10.1038/nbt.2580

Cited by 859 publications

(843 citation statements)

References 26 publications

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“…For the PNAGA‐PCBAA‐10‐4 hydrogel, the fibrotic response was much lower compared to the PNAGA hydrogel owing to the superhydrophilicity of PCBAA introduced 25, 39. This excellent antiprotein property will allow for the alleviating the foreign body reactions.…”

Section: Resultsmentioning

confidence: 99%

Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body

Wang

Cui

et al. 2018

Advanced Science

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Recently, there has been a high expectation that high water absorbent hydrogels can be developed as an artificial vitreous body. However, the drawbacks associated with in vivo instability, biofouling, uncontrollable in situ reaction time, and injection‐induced precrosslinked fragmentation preclude their genuine use as vitreous substitutes. Here, a supramolecular binary copolymer hydrogel termed as PNAGA‐PCBAA by copolymerization of N‐acryloyl glycinamide (NAGA) and carboxybetaine acrylamide (CBAA) is prepared. This PNAGA‐PCBAA hydrogel physically crosslinked by dual amide hydrogen bonds of NAGA exhibits an ultralow solid content (1.6, 98.4 wt% water content), and shear‐thinning behavior, body temperature extrudability/self‐healability, rapid network recoverability, and very close key parameters (modulus, antifouling/antifibrosis, light transmittance, refractive index, ultrastability) to human vitreous body. It is demonstrated that the hydrogel can be readily injected by a 22G needle into the rabbits' eyes where the gelling network is rapidly recovered. After 16 weeks postoperation, the hydrogel acts as a very stable vitreous substitute without affecting the structure of soft tissues in eye, or eliciting adverse effects. This supramolecular binary copolymer hydrogel finds a broad application in ophthalmic fields as not only a self‐recoverable permanent vitreous substitute, but also transient intraocular filling for prevention of inner tissues in postsurgical eyes.

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Section: Resultsmentioning

confidence: 99%

Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body

Wang

Cui

et al. 2018

Advanced Science

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“…Testing is known of different hydrogels that show effective anti-adhesive behaviour on other tissues, for the prevention of epidural fibrosis. Examples of this are zwitterionic hydrogels on subcutaneous implantation (Zhang et al, 2013) and chitosan dextran gel on abdominal peritoneum (Rajiv et al, 2017). In addition, efforts are made to develop hydrogels with more in situ durability, either by using new materials, such as silk-polyethylene glycol hydrogel (Wang et al, 2015) and poloxamer-based gel (Shin et al, 2016), or by modulating the crosslinking process (Lin et al, 2015).…”

Section: Mh Hu Et Almentioning

confidence: 99%

In situ forming oxidised hyaluronic acid/adipic acid dihydrazide hydrogel for prevention of epidural fibrosis after laminectomy

Yang²,

Sun

et al. 2017

eCM

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Post-operative epidural fibrosis is a biological response after laminectomy that may lead to clinical symptoms, such as radicular pain. An ideal material for prevention of epidural fibrosis should be able to inhibit fibroblast adhesions and reduce formation of scar tissue. An injectable hydrogel would be the material of choice for this purpose, since it could fill an irregular surgical defect completely, gelate in situ and be delivered in a minimally-invasive manner. The objective of this study was to evaluate, in vitro and in vivo, the cytocompatibility and anti-adhesive effect of an oxidised hyaluronic acid/adipic acid dihydrazide (oxi-HA/ADH) hydrogel. Different cell types present in the spine were used to test the cytocompatibility of the hydrogel. The hydrogel extraction medium had no deleterious effects on neural cells (PC-12), but reduced fibroblasts viability (NIH/3T3). Although the hydrogel did not change the release of lactate dehydrogenase from myoblasts (C2C12) and Schwann cells (RSC96), the extraction medium concentration slightly affected the mitochondrial activity of these two cell types. qPCR showed that the hydrogel down-regulated S100a and P4hb expression in NIH/3T3 cells, supporting the hypothesis that the hydrogel might inhibit fibroblast activity. The animal study showed a reduction of scar tissue formation as well as severity of adhesion between scar tissue and the dura mater in a rat laminectomy model. Superficially, the peel-off test showed significantly decreased tenacity. In conclusion, the oxi-HA/ADH hydrogel is a promising injectable and thermosensitive material for prevention of post-operative epidural fibrosis.

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“…For example, some hydrogels repel proteins electrostatically, which avoids immune reactions or the biosurface becoming fouled 6 . Repellent coatings on medical devices such as catheters can be based on slippery, liquid-infused, porous surfaces (SLIPS) to prevent thrombosis 7 .…”

Section: Advanced Polymersmentioning

confidence: 99%