Zwitterionic materials for antifouling membrane surface construction

He, Mingrui; Kang, Guozheng; Zhou, Linjie; Jiao, Zhiwei; Wu, Mengyuan; Cao, Jialin; You, Xinda; Cai, Ziyi; Su, Yanlei; Jiang, Zhongyi

doi:10.1016/j.actbio.2016.03.038

Cited by 455 publications

(247 citation statements)

References 101 publications

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“…While biofouling usually starts with the nonspecific adsorption of proteins to the implanted biomaterial surface 34, 35, 36, 37. In the following study, we evaluated the antifouling capacity of our PNAGA‐PCBAA hydrogels by detecting the protein adsorption.…”

Section: Resultsmentioning

confidence: 99%

Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body

Wang

Cui

et al. 2018

Advanced Science

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Recently, there has been a high expectation that high water absorbent hydrogels can be developed as an artificial vitreous body. However, the drawbacks associated with in vivo instability, biofouling, uncontrollable in situ reaction time, and injection‐induced precrosslinked fragmentation preclude their genuine use as vitreous substitutes. Here, a supramolecular binary copolymer hydrogel termed as PNAGA‐PCBAA by copolymerization of N‐acryloyl glycinamide (NAGA) and carboxybetaine acrylamide (CBAA) is prepared. This PNAGA‐PCBAA hydrogel physically crosslinked by dual amide hydrogen bonds of NAGA exhibits an ultralow solid content (1.6, 98.4 wt% water content), and shear‐thinning behavior, body temperature extrudability/self‐healability, rapid network recoverability, and very close key parameters (modulus, antifouling/antifibrosis, light transmittance, refractive index, ultrastability) to human vitreous body. It is demonstrated that the hydrogel can be readily injected by a 22G needle into the rabbits' eyes where the gelling network is rapidly recovered. After 16 weeks postoperation, the hydrogel acts as a very stable vitreous substitute without affecting the structure of soft tissues in eye, or eliciting adverse effects. This supramolecular binary copolymer hydrogel finds a broad application in ophthalmic fields as not only a self‐recoverable permanent vitreous substitute, but also transient intraocular filling for prevention of inner tissues in postsurgical eyes.

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Section: Resultsmentioning

confidence: 99%

Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body

Wang

Cui

et al. 2018

Advanced Science

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“…Zwitterionic materials contain both positively- and negatively-charged groups and have neutral charge [58,59,60,61]. Figure 9 shows typical zwitterionic polymers containing betaine groups, which have been widely investigated as antifouling materials to decrease protein adhesion.…”

Section: Membrane Surface Modification Using Hydrophilic Materialsmentioning

confidence: 99%

“…Figure 10 compares the mechanism of antifouling in zwitterions with that in PEG-based materials [58]. PEG comprises one oxygen atom in each repeat unit (–CH 2 CH 2 O–) that can form a hydrogen bond with only one water molecule, while zwitterions can form electrostatic forces with up to eight water molecules, which also being stronger than the hydrogen bonding in PEG/water systems.…”

Section: Membrane Surface Modification Using Hydrophilic Materialsmentioning

confidence: 99%

Membranes with Surface-Enhanced Antifouling Properties for Water Purification

et al. 2017

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Membrane technology has emerged as an attractive approach for water purification, while mitigation of fouling is key to lower membrane operating costs. This article reviews various materials with antifouling properties that can be coated or grafted onto the membrane surface to improve the antifouling properties of the membranes and thus, retain high water permeance. These materials can be separated into three categories, hydrophilic materials, such as poly(ethylene glycol), polydopamine and zwitterions, hydrophobic materials, such as fluoropolymers, and amphiphilic materials. The states of water in these materials and the mechanisms for the antifouling properties are discussed. The corresponding approaches to coat or graft these materials on the membrane surface are reviewed, and the materials with promising performance are highlighted.

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“…Currently, these zwitterionic betaines are being widely used in a variety of biological and medical applications including surface coatings, drug/gene carriers and antibacterial materials16789. Although the exact mechanism describing the non-fouling property has not yet been completely understood, it is generally considered that the strong hydration ability through ionic solvation of these materials plays a key role1011. For example, it was showed that one sulfobetaine structure could tightly bind with 7~8 water molecules, achieving in excellent hydrophilicity12.…”

mentioning

confidence: 99%

“…The methods for fabricating zwitterionic surfaces are generally classified into two approaches of graft-from and graft-to510. In the “graft-from” method, the target zwitterionic layers are usually to be synthesized directly on the substrate surfaces via the steps of initiator immobilization on the surfaces and initiator initiated polymerization15.…”

mentioning

confidence: 99%

Constructing safe and durable antibacterial textile surfaces using a robust graft-to strategy via covalent bond formation

Chung

et al. 2016

Sci Rep

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Recently zwitterionic materials have been widely applied in the biomedical and bioengineering fields due to their excellent biocompatibility. Inspired by these, this study presents a graft-to strategy via covalent bond formation to fabricate safe and durable antibacterial textile surfaces. A novel zwitterionic sulfobetaine containing triazine reactive group was specifically designed and synthesized. MTT assay showed that it had no obvious cytotoxicity to human skin HaCaT cells as verified by ca. 89.9% relative viability at a rather high concentration of 0.8 mg·mL−1. In the evaluation for its skin sensitization, the maximum score for symptoms of erythema and edema in all tests were 0 in all observation periods. The sulfobetaine had a hydrophilic nature and the hydrophilicity of the textiles was enhanced by 43.9% when it was covalently grafted onto the textiles. Moreover, the textiles grafted with the reactive sulfobetaine exhibited durable antibacterial activities, which was verified by the fact that they showed antibacterial rates of 97.4% against gram-positive S. aureus and 93.2% against gram-negative E. coli even after they were laundered for 30 times. Therefore, the titled zwitterionic sulfobetaine is safe to human for healthcare and wound dressing and shows a promising prospect on antibacterial textile application.

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Zwitterionic materials for antifouling membrane surface construction

Cited by 455 publications

References 101 publications

Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body

Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body

Membranes with Surface-Enhanced Antifouling Properties for Water Purification

Constructing safe and durable antibacterial textile surfaces using a robust graft-to strategy via covalent bond formation

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