Zwitterionic phosphorylcholine-protected water-soluble Ag nanoparticles

Jin, Qiao; Liu, Xiang-Sheng; Xu, Jun; Ji, Jian; Shen, Jiacong

doi:10.1007/s11426-008-0106-4

Cited by 18 publications

(16 citation statements)

References 16 publications

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“…The modified polymeric membranes showed excellent biocompatibility with cells, proteins, tissues and blood. Similar works were also carried out by several other research groups [20][21][22][23][24].…”

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confidence: 64%

Focus on polymer chemistry papers in Science in China Series B: Chemistry of the year 2009

Ying

2010

Sci. China Chem.

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to a percentage increase of 236% and thereby a great historic breakthrough of the journal. These papers mainly focus on three fields: (1) polymer synthesis, (2) functional polymer materials and (3) biomedical polymers. Several research groups published a series of papers in Science in China Series B: Chemistry and detailedly introduced their works in the related fields.Yan et al. paid a great attention on synthesizing functional polymers [1-2], such as hyperbranched polymers, supramolecular self-assembly and dynamics of polymerization reactions. For example, in ref.[1], they successfully prepared nanohybrids by in situ atom transfer radical polymerization (ATRP) of styrene from titanate nanotubes (TNTs), and the grafted PS content was well controlled and increased with increasing the monomer/initiator ratio. Further copolymerization of tert-butyl acrylate (t-BA) from the surface of PS-g-TNTs was studied, illustrating the "living" characteristics of the surface-induced ATRP method used in this work. Yan et al. also prepared well-defined polystyrene/silica hybrid nanoparticles by the ATRP method.Shen's group research interests are mainly on exploitation and development of new catalysts especially rare earth catalysts and methodologies in polymer synthesis [3][4][5][6]. Discrete ion-pair complexes [Ln(EDBP) 2 (DME)Na(DME) 3 ] [Ln = Er (1), Yb (2), Sm (3)] have been synthesized by the reaction between sodium salt of 2,2′-ethylidene-bis(4,6-ditert-butylphenol)(EDBPH 2 ) and Ln(BH 4 ) 3 ·3THF (Ln = Er, Yb, Sm) followed by centrifugation and recrystalization [3]. The polymerization of alkyl isocyanates catalyzed by rare earth chloride salen complexes/triisobutyl aluminum (Ln(H 2 salen) 2 Cl 3 ·2C 2 H 7 OH/Al(i-Bu) 3 ) at room temperature was also developed [4]. A series of diblock copolymers of poly(methyl methacrylate and 2-perfluorooctylethyl methacrylate) (PMMA-b-PFMA) with various PFMA block lengths were prepared by the ATRP, and their surface structures and properties were investigated by different techniques [5]. Shen et al. at Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (CIAC) have found the catalytic activities of lanthanide compounds in stereospecific polymerization of conjugated dienes in the early 1968, then launched extensive research activities on lanthanide compounds as diene polymerization catalysts, rare earth cis-1,4-polybutatine rubber and cis-1,4-polyisoprene rubber have been industried. Recently, Wang et al. have reviewed to summarize the progress in this field in the past half century [7]. Tang et al. [8-10] synthesized several kinds of hyperbranched polymers such as 1 Ndiethylamino)methyl]phenyl}-3,4-diphenylsilole fluorogen, poly(1-phenyl-1-octyne)s containing different stereogenic and chromophoric pendants, and soluble poly(aroxycarbonylphenylene) etc. They also further investigated the functions and potential applications of those synthesized hyperbranched polymers.Huang et al. focused their researches on long wavelength blue emission materials and further explored thei...

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confidence: 64%

Focus on polymer chemistry papers in Science in China Series B: Chemistry of the year 2009

Ying

2010

Sci. China Chem.

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“…Furthermore, it has also been reported that coating by zwitterionic structure is helpful in evading uptake by RES and achieving long blood circulation time 53–55. Zwitterionic polymers have been coated on the surface of nanoparticles like silver,56 gold,57, 58 silica,59, 60 quantum dots61 and magnetite nanoparticles62 to enhance biocompatility and stability or to prolong in vivo circulation time. The inconsistent results from the above studies may be due to the difference of nanoparticle types, variation in stability of nanoparticles resulting from surface charge, the nature of charged groups, and other confounding factors such as inhomogeneous particle sizes.…”

Section: Surface Propertiesmentioning

confidence: 99%

Physicochemical Characteristics of Nanoparticles Affect Circulation, Biodistribution, Cellular Internalization, and Trafficking

Duan

2012

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Nanoparticles have many potential applications in tumor therapy. Systemically administered nanoparticles should remain in circulation for a long time to increase their accumulation in targeted tissues before being cleared by the reticuloendothelial system, and be effectively internalized by the targeted cells, which can be influenced significantly by the physicochemical characteristics of nanoparticles, such as particle size, surface properties, and particle shape. This review highlights the impact of the main affects of physicochemical properties on nanoparticle transport behavior in blood, their uptake and clearance by macrophages and their consequent biodistribution, as well as their interaction with targeted cells.

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“…Inspired by the electrically‐neutral head group of the naturally occurring phospholipid phosphatidylcholine, Jin et al . synthesized the thioalkylated phosphorylcholine, 11‐mercaptoundecylphosphorylcholine (HS‐PC), and used it to prepare zwitterionic‐coated silver nanoparticles (structure 12 , Figure ).…”

Section: Zwitterionic Coatings: a Viable Route Forward?mentioning

confidence: 99%

Zwitterionic‐Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System

García

Zarschler

Barbaro

et al. 2014

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Nanoparticles represent highly promising platforms for the development of imaging and therapeutic agents, including those that can either be detected via more than one imaging technique (multi-modal imaging agents) or used for both diagnosis and therapy (theranostics). A major obstacle to their medical application and translation to the clinic, however, is the fact that many accumulate in the liver and spleen as a result of opsonization and scavenging by the mononuclear phagocyte system. This focused review summarizes recent efforts to develop zwitterionic-coatings to counter this issue and render nanoparticles more biocompatible. Such coatings have been found to greatly reduce the rate and/or extent of non-specific adsorption of proteins and lipids to the nanoparticle surface, thereby inhibiting production of the "biomolecular corona" that is proposed to be a universal feature of nanoparticles within a biological environment. Additionally, in vivo studies have demonstrated that larger-sized nanoparticles with a zwitterionic coating have extended circulatory lifetimes, while those with hydrodynamic diameters of ≤5 nm exhibit small-molecule-like pharmacokinetics, remaining sufficiently small to pass through the fenestrae and slit pores during glomerular filtration within the kidneys, and enabling efficient excretion via the urine. The larger particles represent ideal candidates for use as blood pool imaging agents, whilst the small ones provide a highly promising platform for the future development of theranostics with reduced side effect profiles and superior dose delivery and image contrast capabilities.

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Zwitterionic phosphorylcholine-protected water-soluble Ag nanoparticles

Cited by 18 publications

References 16 publications

Focus on polymer chemistry papers in Science in China Series B: Chemistry of the year 2009

Focus on polymer chemistry papers in Science in China Series B: Chemistry of the year 2009

Physicochemical Characteristics of Nanoparticles Affect Circulation, Biodistribution, Cellular Internalization, and Trafficking

Zwitterionic‐Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System

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