Zymosan priming protects rats against pulmonary oxygen toxicity

Berg, John T.

doi:10.1007/s00011-006-6047-5

Cited by 2 publications

(3 citation statements)

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“…For example, endotoxin protects rats against oxygen toxicity when given by either intraperitoneal or intravenous injection whereas zymosan protects only when given intravenously. 9 Also, endotoxin is protective when given as late as 36 h into oxygen exposure 10 while zymosan requires multiple injections with a two-day rest period before hyperoxia as shown in this study. These observations demonstrate that endotoxin acts quickly (more directly) while zymosan acts more slowly and may involve the immune response at some level.…”

Section: Introductionmentioning

confidence: 66%

“…7 We have previously reported that zymosan priming protects rats against oxygen toxicity. 9 In that study, rats received zymosan priming with endotoxin-free zymosan according to a standard priming protocol involving three daily intravenous injections with zymosan followed by two days' rest before hyperoxia. 3 This study was conducted to determine the limits of treatment parameters on zymosan priming protection.…”

Section: Discussionmentioning

confidence: 99%

“…This laboratory previously reported that zymosan priming protects rats from pulmonary oxygen toxicity. 9 The extent of protection against hyperoxia is similar to that afforded by endotoxin, but there are major differences between protection by endotoxin and zymosan. For example, endotoxin protects rats against oxygen toxicity when given by either intraperitoneal or intravenous injection whereas zymosan protects only when given intravenously.…”

Section: Introductionmentioning

confidence: 99%

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Zymosan priming protects rats against pulmonary oxygen toxicity: characterization of the model

Berg

2010

Exp Biol Med (Maywood)

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This laboratory previously reported that zymosan priming protects rats against pulmonary oxygen toxicity. That study used a standard priming protocol (3 daily intravenous injections [15 mg zymosan/rat] with 2 days' rest) before hyperoxia. This study confirms that report and more fully characterizes the zymosan priming model. Three studies were conducted to establish the (1) effects of dosage, (2) role of duration of rest period between injections and hyperoxia and (3) importance of injection number, on protection by zymosan priming. Rats were exposed to >95% oxygen for 52 h or room air and acute lung injury was quantitated using standard methods. Lung injury decreased (P < 0.05 versus saline controls) in all groups of zymosan-primed rats (3 daily intravenous injections [1-15 mg zymosan/rat] with 2 days' rest before hyperoxia). Although the differences between zymosan-primed groups were not statistically significant, protection (as indicated by decreasing mean values of measured parameters of lung injury) increased with dosage. A one-day rest after injections was sufficient to partially protect zymosan-primed rats from hyperoxia (some measured parameters in the zymosan-primed group differed significantly from comparable values in the Saline group), but full protection (all measured parameters within a group differed significantly from Saline values) was not produced until rats received two days' rest before hyperoxia. Finally, one or two zymosan treatments produced partial protection against oxygen toxicity but three injections were needed to produce full protection. In conclusion, this study found that the standard priming protocol (3 zymosan injections with 2 days' rest before hyperoxia) was the most effective in protecting rats against hyperoxia.

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Section: Introductionmentioning

confidence: 66%