Zystische Tumoren des Pankreas

Grützmann, Robert; Saeger, Hans‐Detlev

doi:10.1007/s00104-009-1861-2

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…The accurate prevalence of MCN is difficult to assess; a recent publication by Valsangkar et al reported about 23% of MCN in patients with resected cystic tumors of the pancreas [84]. MCNs mainly occur in women and are typically located in the pancreatic body and tail [42, 60, 85, 86]. These cystic lesions are almost solitary and the vast majority of MCNs are asymptomatic and found incidentally [15].…”

Section: Mucinous Cystic Neoplasm (Mcn)mentioning

confidence: 99%

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Precursor Lesions for Sporadic Pancreatic Cancer: PanIN, IPMN, and MCN

Distler

Aust

Weitz

et al. 2014

BioMed Research International

164

114

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Pancreatic cancer is still a dismal disease. The high mortality rate is mainly caused by the lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed in an advanced and incurable stage. Knowledge about precursor lesions for pancreatic cancer has grown significantly over the last decade, and nowadays we know that mainly three lesions (PanIN, and IPMN, MCN) are responsible for the development of pancreatic cancer. The early detection of these lesions is still challenging but provides the chance to cure patients before they might get an invasive pancreatic carcinoma. This paper focuses on PanIN, IPMN, and MCN lesions and reviews the current level of knowledge and clinical measures.

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Section: Mucinous Cystic Neoplasm (Mcn)mentioning

confidence: 99%

“…Because, in particular, MCNs mainly occur in young patients and are mostly located in the body and tail of the pancreas, resection is the most appropriate and reliable treatment [42, 50]. …”

Section: Mucinous Cystic Neoplasm (Mcn)mentioning

confidence: 99%

Precursor Lesions for Sporadic Pancreatic Cancer: PanIN, IPMN, and MCN

Distler

Aust

Weitz

et al. 2014

BioMed Research International

164

114

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Familiäres Pankreaskarzinom

Ehehalt

Grützmann

2011

Chirurg

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Less than 10% of pancreatic ductal adenocarcinomas are based on a hereditary syndrome. In contrast a positive family history for pancreatic cancer raises the individual risk for the development of pancreatic and extrapancreatic malignancies.While 70% of hereditary pancreatic carcinomas can be attributed to the familiar pancreatic cancer syndrome 30% are caused by other hereditary syndromes, e.g., Peutz-Jeghers syndrome or familial adenomatous polyposis. Furthermore, genetically determined pancreatitis (e.g., hereditary pancreatitis or cystic fibrosis) can lead to pancreatic cancer.Up to now conclusive data for routine screening of high risk patients are not available which is due in part to the difficult identification of high risk patients and the problematic classification of detected pancreatic lesions. Therefore, high risk patients should be included in controlled clinical trials for screening. Small pancreatic lesions are not clear indications for surgical resection as false positive results can hamper a clear diagnosis and prophylactic pancreatectomy is not recommended. In the case of a histologically proven carcinoma a prophylactic extension of resection might be reasonable. Prevention of familial pancreatic cancer can be achieved through nicotine abstinence.

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Neue Aspekte in der Chirurgie des Pankreaskarzinoms

Distler

Grützmann

2012

Pathologe

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Ductal adenocarcinoma is the most frequent malignant tumor of the pancreas and total resection of the pancreatic tumor is still the only curative treatment option. Most tumors are located in the pancreatic head, therefore, pylorus-preserving pancreaticoduodenectomy (Whipple PPPD) is the oncological standard procedure. By concentrating pancreatic resections in specialized centers for pancreatic surgery perioperative mortality and morbidity has decreased in recent years. However, pancreatic resections remain complex and difficult operations and pancreatic anastomosis is particular challenging. To achieve complete resection (R0) resection and reconstruction of large venous vessels is often necessary. Resection of arterial vessels is rarely performed and usually does not lead to an R0 resection of the tumor. Currently adjuvant chemotherapy after total tumor resection is standard of care for all tumor stages but neoadjuvant regimes have recently been reported increasingly more often. Advances in translational research has led to a better understanding of tumor biology and new diagnostic options and therapies are expected in the near future.

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Zystische Tumoren des Pankreas

Cited by 4 publications

References 42 publications

Precursor Lesions for Sporadic Pancreatic Cancer: PanIN, IPMN, and MCN

Precursor Lesions for Sporadic Pancreatic Cancer: PanIN, IPMN, and MCN

Familiäres Pankreaskarzinom

Neue Aspekte in der Chirurgie des Pankreaskarzinoms

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